DSCAML1 and MAGI2

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DSCAML1	MAGI2
Gene Name		Down syndrome cell adhesion molecule like 1	membrane associated guanylate kinase, WW and PDZ domain containing 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Integral Component Of Membrane	Nucleus Cytoplasm Late Endosome Plasma Membrane Tight Junction Postsynaptic Density Dendrite Slit Diaphragm Protein Complex Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Homodimerization Activity	Signal Transducer Activity Protein Binding Phosphatase Binding Receptor Signaling Complex Scaffold Activity Beta-1 Adrenergic Receptor Binding SMAD Binding Type II Activin Receptor Binding
	Biological Process	Cell Fate Determination Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Axonogenesis Central Nervous System Development Brain Development Dorsal/ventral Pattern Formation Embryonic Skeletal System Morphogenesis Dendrite Self-avoidance	Positive Regulation Of Receptor Internalization Planar Cell Polarity Pathway Involved In Axis Elongation Negative Regulation Of Cell Proliferation Positive Regulation Of Neuron Projection Development Cytoplasmic Transport Negative Regulation Of Cell Migration Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Activin Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Receptor Clustering Protein Heterooligomerization Negative Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Mitotic Cell Cycle Arrest Glomerular Visceral Epithelial Cell Development Cellular Response To Nerve Growth Factor Stimulus
Pathways		DSCAM interactions	Nephrin interactions
Drugs
Diseases
GWAS		Menarche (age at onset) ( 23599027) Triglycerides ( 19074352)	Acute lymphoblastic leukemia (childhood) ( 23007406) Hippocampal atrophy ( 19668339) Obesity-related traits ( 23251661) Response to antidepressant treatment ( 22041458)
Protein-Protein Interactions		3 interactors: MAGI2 MAGI3 PLCL2	15 interactors: ACVR2A ADRB1 ARRDC3 ATN1 BAI1 CTNNB1 CTNND2 DLL1 DSCAML1 GRID2 PLXNB3 PTEN RAPGEF2 SMAD3 TGFA
Entrez ID		57453	9863
HPRD ID		10921	16212
Ensembl ID		ENSG00000177103	ENSG00000187391
Uniprot IDs		Q8TD84	Q86UL8
PDB IDs		1VA9	1UEP 1UEQ 1UEW 1UJV 1WFV
Enriched GO Terms of Interacting Partners?		Planar Cell Polarity Pathway Involved In Axis Elongation B-1a B Cell Differentiation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Receptor Binding B-1 B Cell Differentiation Negative Regulation Of B Cell Receptor Signaling Pathway B Cell Proliferation Involved In Immune Response Negative Regulation Of Activin Receptor Signaling Pathway Glomerular Visceral Epithelial Cell Development Positive Regulation Of Phosphoprotein Phosphatase Activity Nerve Growth Factor Signaling Pathway Regulation Of Signal Transduction Mitotic Cell Cycle Arrest Glomerular Visceral Epithelial Cell Differentiation Regulation Of B Cell Receptor Signaling Pathway Regulation Of Signaling Positive Regulation Of Receptor Internalization Mature B Cell Differentiation Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Activin Receptor Signaling Pathway Cellular Response To Nerve Growth Factor Stimulus Gamma-aminobutyric Acid Signaling Pathway Positive Regulation Of Phosphatase Activity Regulation Of Receptor Internalization Non-canonical Wnt Signaling Pathway Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Synaptic Transmission, GABAergic Axis Elongation Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Protein Kinase B Signaling Cell Differentiation Involved In Kidney Development B Cell Proliferation Regulation Of Protein Phosphorylation Positive Regulation Of Dephosphorylation B Cell Activation Involved In Immune Response Negative Regulation Of Signal Transduction Receptor Clustering SMAD Protein Signal Transduction Negative Regulation Of Signaling Nucleotide Phosphorylation Glomerulus Development Positive Regulation Of Protein Binding Regulation Of Phosphorylation Positive Regulation Of JUN Kinase Activity Regulation Of JUN Kinase Activity Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of Phosphatase Activity B Cell Differentiation Regulation Of Peptidyl-serine Phosphorylation	Developmental Process Multicellular Organismal Development Anatomical Structure Development Anatomical Structure Morphogenesis System Development Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Development Regulation Of Epithelial Cell Proliferation Regulation Of Cell Adhesion Generation Of Neurons Regulation Of Cell Differentiation Organ Development Nervous System Development Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Neurogenesis Neuron Differentiation Embryonic Skeletal System Development Signal Transduction Cell Fate Determination Positive Regulation Of Protein Metabolic Process Cell Development Cell Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Junction Assembly Signaling Regulation Of Cellular Component Organization Pattern Specification Process Cell Communication Cardiovascular System Development Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process Negative Regulation Of Dendrite Morphogenesis Regulation Of Apoptotic Process Regulation Of Postsynaptic Membrane Potential Anterior/posterior Pattern Specification Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Embryonic Heart Tube Development Central Nervous System Development Embryonic Pattern Specification Regulation Of Cell Death Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Ossification
Tagcloud ?			16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 mef2c microdeletions microduplications scn2a spasms stxbp1 xq28
Tagcloud (Difference) ?			16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 mef2c microdeletions microduplications scn2a spasms stxbp1 xq28
Tagcloud (Intersection) ?