DSCAML1 and PLCL2

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
HPRD (two hybrid)

		DSCAML1	PLCL2
Gene Name		Down syndrome cell adhesion molecule like 1	phospholipase C-like 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Integral Component Of Membrane	Cytoplasm
	Molecular Function	Protein Homodimerization Activity	Phosphatidylinositol Phospholipase C Activity Signal Transducer Activity GABA Receptor Binding
	Biological Process	Cell Fate Determination Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Axonogenesis Central Nervous System Development Brain Development Dorsal/ventral Pattern Formation Embryonic Skeletal System Morphogenesis Dendrite Self-avoidance	B Cell Proliferation Involved In Immune Response B-1a B Cell Differentiation Lipid Metabolic Process Gamma-aminobutyric Acid Signaling Pathway Regulation Of Synaptic Transmission, GABAergic Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Negative Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Receptor Binding
Pathways		DSCAM interactions
Drugs
Diseases
GWAS		Menarche (age at onset) ( 23599027) Triglycerides ( 19074352)	Multiple sclerosis ( 21833088) Primary biliary cirrhosis ( 21399635)
Protein-Protein Interactions		3 interactors: MAGI2 MAGI3 PLCL2	2 interactors: DSCAML1 PPP1CA
Entrez ID		57453	23228
HPRD ID		10921	07147
Ensembl ID		ENSG00000177103	ENSG00000154822
Uniprot IDs		Q8TD84	Q9UPR0
PDB IDs		1VA9
Enriched GO Terms of Interacting Partners?		Planar Cell Polarity Pathway Involved In Axis Elongation B-1a B Cell Differentiation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Receptor Binding B-1 B Cell Differentiation Negative Regulation Of B Cell Receptor Signaling Pathway B Cell Proliferation Involved In Immune Response Negative Regulation Of Activin Receptor Signaling Pathway Glomerular Visceral Epithelial Cell Development Positive Regulation Of Phosphoprotein Phosphatase Activity Nerve Growth Factor Signaling Pathway Regulation Of Signal Transduction Mitotic Cell Cycle Arrest Glomerular Visceral Epithelial Cell Differentiation Regulation Of B Cell Receptor Signaling Pathway Regulation Of Signaling Positive Regulation Of Receptor Internalization Mature B Cell Differentiation Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Activin Receptor Signaling Pathway Cellular Response To Nerve Growth Factor Stimulus Gamma-aminobutyric Acid Signaling Pathway Positive Regulation Of Phosphatase Activity Regulation Of Receptor Internalization Non-canonical Wnt Signaling Pathway Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Synaptic Transmission, GABAergic Axis Elongation Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Protein Kinase B Signaling Cell Differentiation Involved In Kidney Development B Cell Proliferation Regulation Of Protein Phosphorylation Positive Regulation Of Dephosphorylation B Cell Activation Involved In Immune Response Negative Regulation Of Signal Transduction Receptor Clustering SMAD Protein Signal Transduction Negative Regulation Of Signaling Nucleotide Phosphorylation Glomerulus Development Positive Regulation Of Protein Binding Regulation Of Phosphorylation Positive Regulation Of JUN Kinase Activity Regulation Of JUN Kinase Activity Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of Phosphatase Activity B Cell Differentiation Regulation Of Peptidyl-serine Phosphorylation	Dendrite Self-avoidance Regulation Of Glycogen Catabolic Process Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Recognition Regulation Of Glycogen Metabolic Process Cell Fate Determination Glycogen Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Circadian Regulation Of Gene Expression Polysaccharide Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Triglyceride Metabolic Process Regulation Of Circadian Rhythm Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Glucose Metabolic Process Neutral Lipid Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Dorsal/ventral Pattern Formation Cell Recognition Embryonic Skeletal System Morphogenesis Anatomical Structure Morphogenesis Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Lipid Catabolic Process Regulation Of Carbohydrate Metabolic Process Embryonic Skeletal System Development
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