ABHD6 and FIS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ABHD6	FIS1
Description		abhydrolase domain containing 6, acylglycerol lipase	fission, mitochondrial 1
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GO Annotations	Cellular Component	Mitochondrion Lysosome Lysosomal Membrane Endosome Plasma Membrane Membrane Late Endosome Membrane Mitochondrial Membrane AMPA Glutamate Receptor Complex Postsynaptic Membrane Glutamatergic Synapse GABA-ergic Synapse	Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Cytosol Membrane Protein-containing Complex
	Molecular Function	Catalytic Activity Phospholipase Activity Protein Binding Hydrolase Activity Monoacylglycerol Lipase Activity	Protein Binding Lipid Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Lipid Metabolic Process Phospholipid Catabolic Process Arachidonate Metabolic Process Negative Regulation Of Cell Migration Acylglycerol Catabolic Process Positive Regulation Of Lipid Biosynthetic Process Monoacylglycerol Catabolic Process Long-term Synaptic Depression Regulation Of Retrograde Trans-synaptic Signaling By Endocanabinoid Negative Regulation Of Cold-induced Thermogenesis Regulation Of Endocannabinoid Signaling Pathway Lysobisphosphatidic Acid Metabolic Process	Mitochondrial Fission Protein Targeting To Mitochondrion Apoptotic Process Mitochondrion Organization Response To Muscle Activity Peroxisome Fission Response To Nutrient Levels Response To Endoplasmic Reticulum Stress Positive Regulation Of Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Cellular Response To Glucose Stimulus Cellular Response To Lipid Positive Regulation Of Mitochondrial Fission Cellular Response To Toxic Substance Cellular Response To Peptide Response To Fluoride Negative Regulation Of ATP Metabolic Process Response To Flavonoid Response To Hypobaric Hypoxia Negative Regulation Of Fatty Acid Transport Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Arachidonate production from DAG	Class I peroxisomal membrane protein import
Drugs
Diseases
GWAS		Hemoglobin levels ( 32327693) Platelet count ( 27863252) Refractive error ( 32231278) Rheumatoid arthritis ( 24390342 30423114) Systemic lupus erythematosus ( 26502338 27399966)	Rheumatoid arthritis ( 30891314)
Interacting Genes		6 interacting genes: CKMT2 FIS1 PCGF2 RTP2 SCAMP4 TVP23B	31 interacting genes: A2M ABHD6 APH1A AQP6 BCAP31 CREB3 DNM1L EBP ERGIC3 FAM209A FAM210B FFAR2 JAGN1 KASH5 KCNJ6 MARCHF5 MMGT1 NOS3 PIGP RNASEK SCN3B SLC10A6 SLC14A1 SLC22A1 SLC22A2 SPCS1 TBC1D15 TMEM14B TMPPE UBC VKORC1
Entrez ID		57406	51024
HPRD ID		12407	12352
Ensembl ID		ENSG00000163686	ENSG00000214253
Uniprot IDs		Q9BV23	Q9Y3D6
PDB IDs		7OTS	1NZN 1PC2 7YA9 7YKA 8U1Z 8XWX
Enriched GO Terms of Interacting Partners?			Membrane Endoplasmic Reticulum Membrane Monoatomic Ion Transport Pyrimidine Nucleoside Transmembrane Transporter Activity Monoatomic Cation Transport Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Endoplasmic Reticulum Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Norepinephrine Uptake Xenobiotic Transport Across Blood-brain Barrier Toxin Transmembrane Transporter Activity Polyamine Transmembrane Transport Serotonin Uptake Norepinephrine Transport Prostaglandin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Golgi Membrane Transmembrane Transport Organic Cation Transmembrane Transporter Activity Catecholamine Uptake Dopamine Uptake Azole Transmembrane Transport Serotonin Transport Quaternary Ammonium Group Transport Prostaglandin Transport Pyrimidine-containing Compound Transmembrane Transport Neurotransmitter Transmembrane Transporter Activity Vitamin Transmembrane Transport Organic Anion Transmembrane Transporter Activity Mitochondrial Outer Membrane Dopamine Transport Neurotransmitter Reuptake Metal Ion Transport Positive Regulation Of Mitochondrial Fission Neutrophil Mediated Immunity Xenobiotic Transmembrane Transporter Activity Water Transport One-carbon Compound Transport Cellular Detoxification Positive Regulation Of Protein Transport
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