SPC25 and SEC61B

Number of citations of the paper that reports this interaction (PMID 9585408)
28

Data Source:
HPRD (in vivo)

		SPC25	SEC61B
Gene Name		SPC25, NDC80 kinetochore complex component	Sec61 beta subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleus Cytosol Ndc80 Complex	Endoplasmic Reticulum Membrane Integral Component Of Membrane Endoplasmic Reticulum Sec Complex
	Molecular Function	Protein Binding	Protein Binding Poly(A) RNA Binding Epidermal Growth Factor Binding
	Biological Process	Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Division Cell Division	Protein Import Into Nucleus, Translocation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Translation SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression ER-associated Ubiquitin-dependent Protein Catabolic Process Retrograde Protein Transport, ER To Cytosol Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cellular Protein Metabolic Process
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Translation SRP-dependent cotranslational protein targeting to membrane Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: NDC80 SEC61B	12 interactors: APOB ARL6 ASNA1 ATP13A2 BAG6 GET4 SEC63 SERP1 SPC25 TRAM1 UBC UBL4A
Entrez ID		57405	10952
HPRD ID		15465	06715
Ensembl ID		ENSG00000152253	ENSG00000106803
Uniprot IDs		Q9HBM1	P60468
PDB IDs		2VE7 3IZ0
Enriched GO Terms of Interacting Partners?		Attachment Of Mitotic Spindle Microtubules To Kinetochore Retrograde Protein Transport, ER To Cytosol Attachment Of Spindle Microtubules To Kinetochore Protein Import Into Nucleus, Translocation ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Localization Establishment Of Mitotic Spindle Orientation Mitotic Spindle Organization Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Localization Spindle Localization Microtubule Anchoring Mitotic Sister Chromatid Segregation Protein Localization Sister Chromatid Segregation Establishment Of Localization In Cell SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Establishment Of Cell Polarity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Protein Import Into Nucleus Nuclear Import Protein Localization To Endoplasmic Reticulum Cellular Localization Spindle Organization Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Import Protein Targeting To Membrane Protein Localization To Nucleus Establishment Or Maintenance Of Cell Polarity Chromosome Segregation Antigen Processing And Presentation Of Peptide Antigen Establishment Of Protein Localization To Membrane Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Nucleocytoplasmic Transport Nuclear Transport Antigen Processing And Presentation	Establishment Of Protein Localization To Membrane Membrane Organization Protein Localization To Membrane Protein Insertion Into ER Membrane Protein Localization To Organelle Establishment Of Protein Localization Protein Insertion Into Membrane Protein Localization Tail-anchored Membrane Protein Insertion Into ER Membrane Endoplasmic Reticulum Organization Transport Cellular Protein Localization Cellular Localization Protein Targeting To Membrane Endomembrane System Organization SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Protein Transport Protein Localization To Endoplasmic Reticulum Protein Targeting Multicellular Organismal Aging Organelle Organization Posttranslational Protein Targeting To Membrane, Translocation Intracellular Transport Establishment Of Protein Localization To Organelle Intracellular Protein Transport Intermembrane Transport Signal Transduction By P53 Class Mediator Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Establishment Of Localization In Cell Protein Acetylation Post-embryonic Development Glucose Metabolic Process Receptor Transactivation Cellular Response To Manganese Ion Response To Endoplasmic Reticulum Stress Posttranslational Protein Targeting To Membrane Mammary Gland Branching Involved In Thelarche Protein Catabolic Process Response To Selenium Ion Positive Regulation Of Growth Hormone Secretion Very-low-density Lipoprotein Particle Assembly Intracellular Receptor Signaling Pathway Cytoplasmic Transport Regulation Of Insulin Secretion Triglyceride Mobilization
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