SPC25

Gene Name		SPC25, NDC80 kinetochore complex component
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Gene Ontology Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleus Cytosol Ndc80 Complex
	Molecular Function	Protein Binding
	Biological Process	Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Division Cell Division
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: NDC80 SEC61B
Entrez ID		57405
HPRD ID		15465
Ensembl ID		ENSG00000152253
Uniprot IDs		Q9HBM1
PDB IDs		2VE7 3IZ0
Enriched GO Terms of Interacting Partners?		Attachment Of Mitotic Spindle Microtubules To Kinetochore Retrograde Protein Transport, ER To Cytosol Attachment Of Spindle Microtubules To Kinetochore Protein Import Into Nucleus, Translocation ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Localization Establishment Of Mitotic Spindle Orientation Mitotic Spindle Organization Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Localization Spindle Localization Microtubule Anchoring Mitotic Sister Chromatid Segregation Protein Localization Sister Chromatid Segregation Establishment Of Localization In Cell SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Establishment Of Cell Polarity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Protein Import Into Nucleus Nuclear Import Protein Localization To Endoplasmic Reticulum Cellular Localization Spindle Organization Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Import Protein Targeting To Membrane Protein Localization To Nucleus Establishment Or Maintenance Of Cell Polarity Chromosome Segregation Antigen Processing And Presentation Of Peptide Antigen Establishment Of Protein Localization To Membrane Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Nucleocytoplasmic Transport Nuclear Transport Antigen Processing And Presentation
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