PTGER1 and PTGER3

Number of citations of the paper that reports this interaction (PMID 11235015)
2

Data Source:
HPRD (in vitro)

		PTGER1	PTGER3
Gene Name		prostaglandin E receptor 1 (subtype EP1), 42kDa	prostaglandin E receptor 3 (subtype EP3)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Nuclear Envelope Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Prostaglandin E Receptor Activity	Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Prostaglandin E Receptor Activity
	Biological Process	G-protein Coupled Receptor Signaling Pathway Response To Lipopolysaccharide	Fever Generation Transcription, DNA-templated G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Death Bicarbonate Transport Intracellular Receptor Signaling Pathway Positive Regulation Of Fever Generation Response To Lipopolysaccharide Positive Regulation Of Urine Volume
Pathways		G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Prostanoid ligand receptors GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Eicosanoid ligand-binding receptors	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Prostanoid ligand receptors GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Eicosanoid ligand-binding receptors
Drugs		Bupivacaine Carboprost Tromethamine Alprostadil Bimatoprost Dinoprostone Iloprost
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ADRB2 PTGDS PTGER3 PTGES PTGFR	23 interactors: ADAMTSL4 CCDC33 CDA EFEMP2 INCA1 KRT31 KRT38 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 MEOX2 MGAT5B MKLN1 NOTCH2NL PTGER1 REL RGS17 RGS20 SPRY2 TCF4 TRIM42
Entrez ID		5731	5733
HPRD ID		08903	08906
Ensembl ID		ENSG00000160951	ENSG00000050628
Uniprot IDs		P34995	B1AK19 O00325 P43115
PDB IDs
Enriched GO Terms of Interacting Partners?		Heat Generation Cyclooxygenase Pathway Response To Lipid Prostaglandin Biosynthetic Process Temperature Homeostasis Prostaglandin Metabolic Process Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Arachidonic Acid Metabolic Process Response To Bacterium Acute Inflammatory Response Icosanoid Metabolic Process Response To External Stimulus Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Response To Other Organism Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Biotic Stimulus Fatty Acid Biosynthetic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Response To Organic Substance Fever Generation Multicellular Organismal Homeostasis G-protein Coupled Receptor Signaling Pathway Cellular Response To Prostaglandin D Stimulus Diet Induced Thermogenesis Fatty Acid Metabolic Process Positive Regulation Of Fever Generation Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Fever Generation Positive Regulation Of Heat Generation Calcium-mediated Signaling Using Intracellular Calcium Source Chronic Inflammatory Response Inflammatory Response Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Urine Volume Adrenergic Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Dietary Excess Parturition Cellular Response To Prostaglandin Stimulus Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Muscle Contraction Negative Regulation Of Systemic Arterial Blood Pressure Response To Stimulus	Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Tagcloud ?		acutely autacoids bdkrb2 bks blots butaprost composing counterpart cyclooxygenases deferens epididymal epithelia hoe140 lining lysylbradykinin prostaglandin prostaglandins ptgs ptgs1 ptgs2 ptgss pvd9902 reportedly sc sulprostone vas	accepted acei bdkrb2 cessation combinations converting cough cpn1 digenic epistatic haplotypes hypertensive kinins mme modify monogenic peptidases polymorphisms prostaglandin prostaglandins ptgir ptgis rs11209716 rs2016848 rs4344 rs8012552 substance unresolved xpnpep1
Tagcloud (Difference) ?		acutely autacoids bks blots butaprost composing counterpart cyclooxygenases deferens epididymal epithelia hoe140 lining lysylbradykinin ptgs ptgs1 ptgs2 ptgss pvd9902 reportedly sc sulprostone vas	accepted acei cessation combinations converting cough cpn1 digenic epistatic haplotypes hypertensive kinins mme modify monogenic peptidases polymorphisms ptgir ptgis rs11209716 rs2016848 rs4344 rs8012552 substance unresolved xpnpep1
Tagcloud (Intersection) ?		bdkrb2 prostaglandin prostaglandins