PTGER1 and PTGFR

Number of citations of the paper that reports this interaction (PubMedID 8253813)
0

Data Source:
HPRD (in vivo)

		PTGER1	PTGFR
Description		prostaglandin E receptor 1	prostaglandin F receptor
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Cytoplasm Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Prostaglandin Receptor Activity Prostaglandin E Receptor Activity D1 Dopamine Receptor Binding	G Protein-coupled Receptor Activity Prostaglandin F Receptor Activity
	Biological Process	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Response To Lipopolysaccharide Response To Prostaglandin E	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Parturition Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Response To Estradiol Response To Lipopolysaccharide Response To Lipid Negative Regulation Of Apoptotic Process Cellular Response To Prostaglandin D Stimulus
Pathways		Prostanoid ligand receptors G alpha (q) signalling events	Prostanoid ligand receptors G alpha (q) signalling events
Drugs		Bupivacaine Carboprost tromethamine Alprostadil Bimatoprost Dinoprostone Misoprostol Iloprost Trichostatin A Limaprost Omidenepag isopropyl Rivenprost	Travoprost Latanoprost Bimatoprost Dinoprost tromethamine Tafluprost Latanoprostene bunod
Diseases
GWAS			Bipolar disorder ( 22182935) Depression in multiple sclerosis (post-diagnosis) ( 33296963) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Skin fluorescence in type 1 diabetes ( 27207532) Systolic blood pressure (alcohol consumption interaction) ( 24376456)
Interacting Genes		5 interacting genes: ADRB2 PTGDS PTGER3 PTGES PTGFR	5 interacting genes: AGTR1 PTGDS PTGER1 PTGER2 PTGES2
Entrez ID		5731	5737
HPRD ID		08903	08988
Ensembl ID		ENSG00000160951	ENSG00000122420
Uniprot IDs		P34995	P43088
PDB IDs			8IQ4 8IQ6 8IUK 8IUL 8IUM 8XJK 8XJL 8XJM
Enriched GO Terms of Interacting Partners?		Prostaglandin-D Synthase Activity Regulation Of Fever Generation Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Prostaglandin Metabolic Process Prostanoid Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Regulation Of Acute Inflammatory Response G Protein-coupled Receptor Activity Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Unsaturated Fatty Acid Metabolic Process Prostaglandin F Receptor Activity Icosanoid Metabolic Process Fatty Acid Biosynthetic Process Beta2-adrenergic Receptor Activity Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Beta-adrenergic Receptor Activity Isomerase Activity Negative Regulation Of Male Germ Cell Proliferation Positive Regulation Of Cytosolic Calcium Ion Concentration Prostaglandin-E Synthase Activity Norepinephrine Binding Negative Regulation Of Gastric Acid Secretion Prostaglandin Receptor Activity Intestine Smooth Muscle Contraction Response To Psychosocial Stress Muscle Contraction Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway Regulation Of Male Germ Cell Proliferation Prostaglandin E Receptor Activity Regulation Of Germ Cell Proliferation Positive Regulation Of Fever Generation Cellular Response To Prostaglandin D Stimulus Muscle System Process Positive Regulation Of Autophagosome Maturation Heat Generation Carboxylic Acid Biosynthetic Process Regulation Of Gastric Acid Secretion Adrenergic Receptor Activity Parturition Diet Induced Thermogenesis Negative Regulation Of Multicellular Organismal Process Retinoid Binding	Prostaglandin E Receptor Activity Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Angiotensin Type I Receptor Activity L-cystine L-cysteine-lyase (deaminating) L-cysteine Desulfhydrase Activity Homocysteine Desulfhydrase Activity Selenocystathionine Gamma-lyase Activity Cystathionine Gamma-lyase Activity Carboxylic Acid Biosynthetic Process Protein Sulfhydration Protein-pyridoxal-5-phosphate Linkage Via Peptidyl-N6-pyridoxal Phosphate-L-lysine Prostanoid Metabolic Process Prostaglandin Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Response To Prostaglandin E Fucose-1-phosphate Guanylyltransferase Activity Efferent Axon Development In A Lateral Line Nerve Medullary Reticular Formation Development Retrotrapezoid Nucleus Neuron Differentiation Ribosomal Large Subunit Biogenesis Noc2p-Noc3p Complex Noc1p-Noc2p Complex G Protein-coupled Receptor Activity Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Cysteine Biosynthetic Process Via Cystathionine Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Unsaturated Fatty Acid Metabolic Process Icosanoid Metabolic Process Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Parasympathetic Nervous System Development Cellular Response To Carbon Dioxide Negative Regulation Of Type B Pancreatic Cell Proliferation Response To Carbon Dioxide Protein Phosphatase Binding IkappaB Kinase Activity 12-hydroxyheptadecatrienoic Acid Synthase Activity Prostaglandin-E Synthase Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Small Molecule Biosynthetic Process Cysteine Biosynthetic Process Transsulfuration
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