PTGER2 and PTGES

Number of citations of the paper that reports this interaction (PubMedID 8163486)
0

Data Source:
HPRD (in vivo)

		PTGER2	PTGES
Description		prostaglandin E receptor 2	prostaglandin E synthase
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Nuclear Envelope Lumen Cytoplasm Endoplasmic Reticulum Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	G Protein-coupled Receptor Activity Prostaglandin E Receptor Activity	Glutathione Transferase Activity Glutathione Peroxidase Activity Prostaglandin-D Synthase Activity Protein Binding Oxidoreductase Activity Transferase Activity Isomerase Activity Glutathione Binding Prostaglandin-E Synthase Activity
	Biological Process	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nematode Response To Lipopolysaccharide Response To Progesterone Regulation Of Cell Population Proliferation Cellular Response To Prostaglandin E Stimulus	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Signal Transduction Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Sensory Perception Of Pain Regulation Of Fever Generation Positive Regulation Of Prostaglandin Secretion Regulation Of Inflammatory Response Cellular Oxidant Detoxification
Pathways		Prostanoid ligand receptors G alpha (s) signalling events	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs		Treprostinil Alprostadil Dinoprostone Misoprostol Trichostatin A Gemeprost Limaprost Omidenepag isopropyl Rivenprost
Diseases
GWAS			Asthma ( 27611488) Pars orbitalis volume ( 31530798) Type 1 diabetes (age at diagnosis) ( 33179336)
Interacting Genes		3 interacting genes: PTGDS PTGES PTGFR	18 interacting genes: ARLN BET1 EHHADH GIMAP1 GIMAP5 PLP2 PTGER1 PTGER2 SEC22A SERP2 SMCO4 TMEM19 TMEM222 TMEM65 VAMP3 VAMP4 VAPB YIF1A
Entrez ID		5732	9536
HPRD ID		08905	05528
Ensembl ID		ENSG00000125384	ENSG00000148344
Uniprot IDs		P43116	O14684
PDB IDs		7CX2 7CX3 7CX4	3DWW 4AL0 4AL1 4BPM 4WAB 4YK5 4YL0 4YL1 4YL3 5BQG 5BQH 5BQI 5K0I 5T36 5T37 5TL9 6VL4 8PYV
Enriched GO Terms of Interacting Partners?		Prostaglandin-D Synthase Activity Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Prostanoid Metabolic Process Prostaglandin Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Unsaturated Fatty Acid Metabolic Process Icosanoid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin F Receptor Activity Isomerase Activity Negative Regulation Of Male Germ Cell Proliferation Prostaglandin-E Synthase Activity Carboxylic Acid Biosynthetic Process Fatty Acid Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Male Germ Cell Proliferation Regulation Of Germ Cell Proliferation Cellular Response To Prostaglandin D Stimulus Regulation Of Fever Generation Parturition Retinoid Binding Glutathione Binding Small Molecule Biosynthetic Process Nuclear Envelope Lumen Monocarboxylic Acid Metabolic Process Positive Regulation Of Prostaglandin Secretion Lipid Biosynthetic Process Positive Regulation Of Icosanoid Secretion Regulation Of Circadian Sleep/wake Cycle, Sleep Glutathione Peroxidase Activity Positive Regulation Of Fatty Acid Transport Response To Hormone Regulation Of Circadian Sleep/wake Cycle Mast Cell Degranulation Small Molecule Binding Cellular Response To Prostaglandin Stimulus Negative Regulation Of Cell Population Proliferation Fatty Acid Binding Organic Acid Metabolic Process Perinuclear Region Of Cytoplasm Carboxylic Acid Metabolic Process Glutathione Transferase Activity Regulation Of Fatty Acid Transport Rough Endoplasmic Reticulum Response To Lipid Leukocyte Degranulation Sensory Perception Of Pain Regulation Of Acute Inflammatory Response	Golgi Vesicle Transport Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport SNAP Receptor Activity Prostaglandin E Receptor Activity SNARE Complex Endoplasmic Reticulum SNARE Complex Assembly Transport Vesicle Vesicle Organization Organelle Fusion Response To Prostaglandin E Membrane Fusion Golgi To Plasma Membrane Protein Transport Vesicle-mediated Transport Intracellular Transport Establishment Of Protein Localization To Plasma Membrane Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Presynaptic Endosome Membrane Golgi To Plasma Membrane Transport Negative Regulation By Virus Of Viral Protein Levels In Host Cell Endoplasmic Reticulum Unfolded Protein Response Clathrin-coated Endocytic Vesicle Membrane Cellular Response To Type II Interferon Synaptic Vesicle To Endosome Fusion FFAT Motif Binding Organelle Localization By Membrane Tethering Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Delta(3)-delta(2)-enoyl-CoA Isomerase Activity Prostaglandin Receptor Activity Cellular Localization Protein Transport Golgi Membrane Phagocytic Vesicle Establishment Of Localization In Cell Membrane Organization Response To Unfolded Protein Membrane Docking Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Response To Type II Interferon Post-Golgi Vesicle-mediated Transport COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Organelle Membrane Fusion Vesicle Fusion (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Trans-Golgi Network Membrane Host-mediated Perturbation Of Viral RNA Genome Replication
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