PTGER2 and PTGES

Number of citations of the paper that reports this interaction (PMID 8163486)
24

Data Source:
HPRD (in vivo)

		PTGER2	PTGES
Gene Name		prostaglandin E receptor 2 (subtype EP2), 53kDa	prostaglandin E synthase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Nuclear Envelope Lumen Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Prostaglandin E Receptor Activity	Glutathione Binding Prostaglandin-E Synthase Activity
	Biological Process	G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Lipopolysaccharide Regulation Of Cell Proliferation Cellular Response To Prostaglandin E Stimulus	Prostaglandin Biosynthetic Process Acute Inflammatory Response Chronic Inflammatory Response Prostaglandin Metabolic Process Signal Transduction Negative Regulation Of Cell Proliferation Response To Organic Cyclic Compound Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Response To Lipopolysaccharide Response To Retinoic Acid Response To Cytokine Small Molecule Metabolic Process Response To Calcium Ion
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Prostanoid ligand receptors Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Eicosanoid ligand-binding receptors	Arachidonic acid metabolism Metabolism of lipids and lipoproteins Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs		Alprostadil Dinoprostone Misoprostol
Diseases
GWAS
Protein-Protein Interactions		3 interactors: PTGDS PTGES PTGFR	2 interactors: PTGER1 PTGER2
Entrez ID		5732	9536
HPRD ID		08905	05528
Ensembl ID		ENSG00000125384	ENSG00000148344
Uniprot IDs		P43116	O14684
PDB IDs			3DWW 4AL0 4AL1
Enriched GO Terms of Interacting Partners?		Cyclooxygenase Pathway Prostaglandin Biosynthetic Process Prostaglandin Metabolic Process Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Arachidonic Acid Metabolic Process Response To Lipid Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Response To Lipopolysaccharide Fatty Acid Metabolic Process Response To Molecule Of Bacterial Origin Cellular Response To Prostaglandin D Stimulus Response To Bacterium Response To Organic Substance Calcium-mediated Signaling Using Intracellular Calcium Source Chronic Inflammatory Response Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Regulation Of Circadian Sleep/wake Cycle, Sleep Parturition Cellular Response To Prostaglandin Stimulus Response To Other Organism Response To Biotic Stimulus Response To Organic Cyclic Compound Response To Hormone Cellular Lipid Metabolic Process Carboxylic Acid Metabolic Process Cellular Response To Fatty Acid Organic Acid Metabolic Process Lipid Metabolic Process Response To Fatty Acid Acute Inflammatory Response Regulation Of Cell Proliferation Calcium-mediated Signaling Regulation Of Circadian Rhythm Response To Calcium Ion Response To Retinoic Acid Response To External Stimulus Second-messenger-mediated Signaling Response To Glucocorticoid Response To Corticosteroid Cellular Response To Acid Chemical Regulation Of Behavior Small Molecule Metabolic Process	Negative Regulation Of Eosinophil Extravasation Negative Regulation Of Integrin Activation Negative Regulation Of Eosinophil Migration Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Response To Bacterium Regulation Of Integrin Activation Response To Other Organism Response To Biotic Stimulus Cellular Response To Prostaglandin E Stimulus Response To Lipid ERK1 And ERK2 Cascade Response To Prostaglandin E Cellular Response To Prostaglandin Stimulus Negative Regulation Of Leukocyte Migration T-helper Cell Differentiation G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cytokine Secretion CD4-positive, Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation Cellular Response To Fatty Acid Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Alpha-beta T Cell Differentiation Regulation Of Stress Fiber Assembly Alpha-beta T Cell Activation T Cell Activation Involved In Immune Response Response To Fatty Acid Response To External Stimulus Cellular Response To Mechanical Stimulus JNK Cascade Positive Regulation Of Cytokine Secretion Positive Regulation Of Inflammatory Response Negative Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response Regulation Of Leukocyte Migration Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Protein Complex Assembly Regulation Of Cytokine Secretion Response To Organic Substance G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger T Cell Differentiation Leukocyte Activation Involved In Immune Response Negative Regulation Of Secretion By Cell Cellular Response To Acid Chemical Negative Regulation Of Secretion Negative Regulation Of Protein Transport Positive Regulation Of Protein Secretion Negative Regulation Of Cell Migration
Tagcloud ?		appeared deltadeltact diestrus endometrium ep2 ep4 equine esr1 esr2 estrus glands immunolabeling immunoreactivity immunostaining intense localize mares myometrium pgr pr pregnancy prostaglandin qpcr quantified reproductive stroma tended weak	acsf artificial avp balance cannulas cart cerebrospinal cerebroventricular circuits creb1 gabrd gip gipr gut hypothalami hypothalamic hypothalamus incretin insulinotrophic mapk1 microl neurocircuitry npy originally oxt polypeptide quantitatively taqman th
Tagcloud (Difference) ?		appeared deltadeltact diestrus endometrium ep2 ep4 equine esr1 esr2 estrus glands immunolabeling immunoreactivity immunostaining intense localize mares myometrium pgr pr pregnancy prostaglandin qpcr quantified reproductive stroma tended weak	acsf artificial avp balance cannulas cart cerebrospinal cerebroventricular circuits creb1 gabrd gip gipr gut hypothalami hypothalamic hypothalamus incretin insulinotrophic mapk1 microl neurocircuitry npy originally oxt polypeptide quantitatively taqman th
Tagcloud (Intersection) ?