PTGER2 and PTGFR

Number of citations of the paper that reports this interaction (PMID 8163486)
24

Data Source:
HPRD (in vivo)

		PTGER2	PTGFR
Gene Name		prostaglandin E receptor 2 (subtype EP2), 53kDa	prostaglandin F receptor (FP)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Prostaglandin E Receptor Activity	Prostaglandin F Receptor Activity
	Biological Process	G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Lipopolysaccharide Regulation Of Cell Proliferation Cellular Response To Prostaglandin E Stimulus	G-protein Coupled Receptor Signaling Pathway Parturition Positive Regulation Of Cell Proliferation Response To Lipopolysaccharide Calcium-mediated Signaling Using Intracellular Calcium Source Negative Regulation Of Apoptotic Process Cellular Response To Prostaglandin D Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Prostanoid ligand receptors Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Eicosanoid ligand-binding receptors	G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Prostanoid ligand receptors GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Eicosanoid ligand-binding receptors
Drugs		Alprostadil Dinoprostone Misoprostol	Travoprost Latanoprost Bimatoprost Dinoprost Tromethamine Tafluprost
Diseases
GWAS			Bipolar disorder ( 22182935)
Protein-Protein Interactions		3 interactors: PTGDS PTGES PTGFR	4 interactors: PTGDS PTGER1 PTGER2 PTGES2
Entrez ID		5732	5737
HPRD ID		08905	08988
Ensembl ID		ENSG00000125384	ENSG00000122420
Uniprot IDs		P43116	P43088
PDB IDs
Enriched GO Terms of Interacting Partners?		Cyclooxygenase Pathway Prostaglandin Biosynthetic Process Prostaglandin Metabolic Process Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Arachidonic Acid Metabolic Process Response To Lipid Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Response To Lipopolysaccharide Fatty Acid Metabolic Process Response To Molecule Of Bacterial Origin Cellular Response To Prostaglandin D Stimulus Response To Bacterium Response To Organic Substance Calcium-mediated Signaling Using Intracellular Calcium Source Chronic Inflammatory Response Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Regulation Of Circadian Sleep/wake Cycle, Sleep Parturition Cellular Response To Prostaglandin Stimulus Response To Other Organism Response To Biotic Stimulus Response To Organic Cyclic Compound Response To Hormone Cellular Lipid Metabolic Process Carboxylic Acid Metabolic Process Cellular Response To Fatty Acid Organic Acid Metabolic Process Lipid Metabolic Process Response To Fatty Acid Acute Inflammatory Response Regulation Of Cell Proliferation Calcium-mediated Signaling Regulation Of Circadian Rhythm Response To Calcium Ion Response To Retinoic Acid Response To External Stimulus Second-messenger-mediated Signaling Response To Glucocorticoid Response To Corticosteroid Cellular Response To Acid Chemical Regulation Of Behavior Small Molecule Metabolic Process	Prostaglandin Biosynthetic Process Prostaglandin Metabolic Process Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Negative Regulation Of Eosinophil Extravasation Response To Lipid Fatty Acid Biosynthetic Process Negative Regulation Of Integrin Activation Negative Regulation Of Eosinophil Migration Response To Lipopolysaccharide Fatty Acid Metabolic Process Response To Molecule Of Bacterial Origin Regulation Of Integrin Activation Cellular Response To Prostaglandin E Stimulus Response To Bacterium Cyclooxygenase Pathway Regulation Of Circadian Sleep/wake Cycle, Sleep ERK1 And ERK2 Cascade Response To Prostaglandin E Cellular Response To Prostaglandin Stimulus Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Negative Regulation Of Leukocyte Migration Response To Organic Substance T-helper Cell Differentiation Response To Other Organism Response To Biotic Stimulus Negative Regulation Of Cytokine Secretion CD4-positive, Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation Cellular Response To Fatty Acid Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Hormone Cellular Lipid Metabolic Process Alpha-beta T Cell Differentiation Carboxylic Acid Metabolic Process Regulation Of Stress Fiber Assembly Arachidonic Acid Metabolic Process Alpha-beta T Cell Activation T Cell Activation Involved In Immune Response Response To Fatty Acid Cellular Response To Mechanical Stimulus Organic Acid Metabolic Process G-protein Coupled Receptor Signaling Pathway JNK Cascade Positive Regulation Of Cytokine Secretion Lipid Metabolic Process Positive Regulation Of Inflammatory Response
Tagcloud ?		appeared deltadeltact diestrus endometrium ep2 ep4 equine esr1 esr2 estrus glands immunolabeling immunoreactivity immunostaining intense localize mares myometrium pgr pr pregnancy prostaglandin qpcr quantified reproductive stroma tended weak	11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgds ptgs2 reaches slco2a synthases
Tagcloud (Difference) ?		appeared deltadeltact diestrus ep2 ep4 equine esr1 esr2 estrus glands immunolabeling immunoreactivity immunostaining intense localize mares myometrium pgr pr pregnancy prostaglandin qpcr quantified reproductive stroma tended weak	11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgds ptgs2 reaches slco2a synthases
Tagcloud (Intersection) ?		endometrium