USP36 and MIR19B2

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		USP36	MIR19B2
Description		ubiquitin specific peptidase 36	microRNA 19b-2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Speck	RISC Complex
	Molecular Function	RNA Binding Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Transferase Activity Hydrolase Activity Histone H2B Deubiquitinase Activity K48-linked Deubiquitinase Activity
	Biological Process	Chromatin Organization Chromatin Remodeling Proteolysis Nucleolus Organization Negative Regulation Of Macroautophagy Protein Deubiquitination Regulation Of Protein Stability Regulation Of Apoptotic Process Protein Stabilization Regulation Of Mitophagy Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of RRNA Processing	MiRNA-mediated Post-transcriptional Gene Silencing
Pathways
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737) Diverticular disease ( 30177863) Heel bone mineral density ( 30598549) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 30578418 31928498)
Interacting Genes		19 interacting genes: ALKBH5 EXOSC10 H2BC3 MIR128-1 MIR138-2 MIR15B MIR16-1 MIR17 MIR19B2 MIR21 MIR29A MIR29C MIR34B MIR7-1 MYC PRIMPOL PTBP1 SUMO2 UBE2I	93 interacting genes: ADARB1 AIMP1 AIMP2 AQR C1QBP CELF1 CPSF1 CPSF6 DARS1 DDX1 DDX21 DDX23 DDX3X DDX3Y DHX36 DHX37 EIF2AK2 EPRS1 ESRP1 FAM98A FUS HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT21 PATL1 PDCD11 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 QKI RARS1 RBFOX2 RBM14 RBM4 RBMS2 RTCA RTCB SART3 SF1 SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 SUGP2 SYMPK SYNCRIP TAF15 TRA2B TRIM25 U2SURP UPF1 USP36 UTP20 YBX1 YBX3 ZFR ZNF346 ZNF385A
Entrez ID		57602	406981
HPRD ID		07164
Ensembl ID		ENSG00000055483	ENSG00000284107
Uniprot IDs		A0A075B784 Q9P275
PDB IDs		8BS3 8BS9
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Negative Regulation Of Metabolic Process Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Regulation Of Translation Positive Regulation Of Connective Tissue Replacement Extracellular Vesicle Regulation Of Connective Tissue Replacement Regulation Of Gene Expression Positive Regulation Of Tissue Remodeling Regulation Of Macromolecule Biosynthetic Process Regulation Of Endothelial Cell Proliferation Negative Regulation Of Amyloid-beta Formation Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Developmental Process Regulation Of Amide Metabolic Process Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Macromolecule Metabolic Process Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Regulation Of Amyloid-beta Formation Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Regulation Of Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Apoptotic Process Regulation Of Cell Cycle G1/S Phase Transition	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process MRNA Binding Nucleobase-containing Compound Metabolic Process Nucleus MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Aminoacyl-tRNA Synthetase Multienzyme Complex Nucleoplasm Post-transcriptional Regulation Of Gene Expression Ribonucleoprotein Complex Spliceosomal Complex MRNA 3'-UTR Binding Catalytic Step 2 Spliceosome Regulation Of Translation MiRNA Binding Cytoplasmic Stress Granule Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Translation Regulation Of Gene Expression Negative Regulation Of RNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity RNA Stabilization TRNA Aminoacylation Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Stability MRNA Stabilization Ligase Activity Regulation Of RNA Stability Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Nucleolus Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Helicase Activity Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cytoplasmic Translation
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