PLXDC1 and NRF1

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		PLXDC1	NRF1
Description		plexin domain containing 1	nuclear respiratory factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Bicellular Tight Junction Membrane Dendrite Neuronal Cell Body Receptor Complex Anchoring Junction	Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Angiogenesis Spinal Cord Development	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways			PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Mitochondrial unfolded protein response (UPRmt)
Drugs
Diseases
GWAS		Asthma ( 31619474) Tau burden ( 33426524)	Bipolar disorder ( 31043756) Obesity-related traits ( 23251661) Platelet count ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Response to antidepressants and depression ( 27622933)
Interacting Genes		4 interacting genes: C5AR2 GPR35 NID1 NRF1	48 interacting genes: AGR2 BBS2 BICRAL BRWD1 C10orf55 C3orf36 CKMT2 COL10A1 CSNK2A1 CSNK2B DYNLL1 ESM1 FHL2 HHIPL1 HIVEP1 KHDC4 KLF15 KPNA5 KRT83 L3MBTL2 L3MBTL3 LHX3 LHX4 LHX6 LMO4 MAFF MVP NDUFAB1 PANX2 PARP1 PLXDC1 POGZ PPARGC1A PPRC1 SIAH2 SLC67A1-AS SP2 SP4 SPMIP10 SPSB2 SRARP TESMIN TOLLIP TRAF2 TRIM35 VEZF1 YPEL3 ZMYM6
Entrez ID		57125	4899
HPRD ID		08439	02930
Ensembl ID		ENSG00000161381	ENSG00000106459
Uniprot IDs		Q8IUK5	Q16656
PDB IDs			8K3D 8K4L
Enriched GO Terms of Interacting Partners?		C-X-C Chemokine Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Basement Membrane Organization Laminin-1 Binding Complement Component C5a Receptor Activity Complement Component C5a Signaling Pathway Negative Regulation Of Neutrophil Migration Complement Receptor Activity Negative Regulation Of Neutrophil Chemotaxis Protein Complex Involved In Cell-matrix Adhesion G Protein-coupled Receptor Activity Positive Regulation Of Integrin-mediated Signaling Pathway Proteoglycan Binding Glomerular Basement Membrane Development Complement Receptor Mediated Signaling Pathway Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Integrin-mediated Signaling Pathway Laminin Binding Negative Regulation Of Leukocyte Chemotaxis Chemokine Receptor Activity Negative Regulation Of Transporter Activity	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Medial Motor Column Neuron Differentiation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Chromatin Zinc Ion Binding Regulation Of Primary Metabolic Process Motor Neuron Axon Guidance Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Metabolic Process Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Spinal Cord Motor Neuron Cell Fate Specification Cell Differentiation In Spinal Cord RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus Spinal Cord Association Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Apoptotic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Programmed Cell Death Cell Death Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm
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