PLXDC1 and C5AR2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		PLXDC1	C5AR2
Description		plexin domain containing 1	complement C5a receptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Bicellular Tight Junction Membrane Dendrite Neuronal Cell Body Receptor Complex Anchoring Junction	Plasma Membrane Basal Plasma Membrane Membrane Apical Part Of Cell
	Molecular Function	Protein Binding	Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Angiogenesis Spinal Cord Development	Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Complement Component C5a Signaling Pathway Negative Regulation Of Neutrophil Chemotaxis
Pathways			Peptide ligand-binding receptors Regulation of Complement cascade
Drugs
Diseases
GWAS		Asthma ( 31619474) Tau burden ( 33426524)
Interacting Genes		4 interacting genes: C5AR2 GPR35 NID1 NRF1	17 interacting genes: ABCA7 ACO2 ARLN C3 C4A C5AR1 CALM3 HAGHL HERC2 HERPUD1 PLXDC1 SCN1B SCRIB SLC25A11 SLC26A11 SYNGR2 TMEM234
Entrez ID		57125	27202
HPRD ID		08439	17072
Ensembl ID		ENSG00000161381	ENSG00000134830
Uniprot IDs		Q8IUK5	Q9P296
PDB IDs
Enriched GO Terms of Interacting Partners?		C-X-C Chemokine Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Basement Membrane Organization Laminin-1 Binding Complement Component C5a Receptor Activity Complement Component C5a Signaling Pathway Negative Regulation Of Neutrophil Migration Complement Receptor Activity Negative Regulation Of Neutrophil Chemotaxis Protein Complex Involved In Cell-matrix Adhesion G Protein-coupled Receptor Activity Positive Regulation Of Integrin-mediated Signaling Pathway Proteoglycan Binding Glomerular Basement Membrane Development Complement Receptor Mediated Signaling Pathway Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Integrin-mediated Signaling Pathway Laminin Binding Negative Regulation Of Leukocyte Chemotaxis Chemokine Receptor Activity Negative Regulation Of Transporter Activity	Positive Regulation Of Apoptotic Cell Clearance Regulation Of Apoptotic Cell Clearance Classical-complement-pathway C3/C5 Convertase Complex Amyloid-beta Clearance Regulation Of Endocytosis Positive Regulation Of Phagocytosis Complement Activation, Lectin Pathway Complement Activation, GZMK Pathway Activation Of Membrane Attack Complex Positive Regulation Of Phagocytosis, Engulfment Complement Receptor Mediated Signaling Pathway Opsonization Regulation Of Phagocytosis Regulation Of Vesicle-mediated Transport Symbiont Cell Surface Transmembrane Transporter Binding Locomotion Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endocytosis Antigen Binding Complement Activation, Classical Pathway Regulation Of Vascular Endothelial Growth Factor Production C5L2 Anaphylatoxin Chemotactic Receptor Binding Endopeptidase Inhibitor Activity Plasma Membrane Presynaptic Endocytosis Corticospinal Neuron Axon Guidance Oxoglutarate:malate Antiporter Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Complement Activation Positive Regulation Of Activation Of Membrane Attack Complex Basolateral Plasma Membrane Negative Regulation Of High Voltage-gated Calcium Channel Activity Neural Nucleus Development Positive Regulation Of Voltage-gated Sodium Channel Activity Apolipoprotein A-I Receptor Activity Positive Regulation Of Engulfment Of Apoptotic Cell Regulation Of Engulfment Of Apoptotic Cell Scrib-APC-beta-catenin Complex
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