CCNL1 and SRSF2

Number of citations of the paper that reports this interaction (PMID 11683997)
23

Data Source:
HPRD (two hybrid, in vitro)

		CCNL1	SRSF2
Gene Name		cyclin L1	serine/arginine-rich splicing factor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Speck	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm PML Body Nuclear Speck Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Binding	Nucleotide Binding Transcription Corepressor Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription, DNA-templated Regulation Of Transcription, DNA-templated RNA Processing	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Processing MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing Negative Regulation Of Nucleic Acid-templated Transcription
Pathways			mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing
Drugs
Diseases
GWAS		Adiposity in newborns ( 23575227) Birth weight ( 23202124 20372150) Diabetic retinopathy ( 21441570) Eating disorders ( 22911880)
Protein-Protein Interactions		6 interactors: APP APPBP2 CDK11A JMJD6 SRSF2 TFIP11	33 interactors: ADAP1 BARD1 CCNL1 CCNL2 CDK12 CDK6 CEP72 CIR1 CSNK2A1 FUS GEMIN2 GOLGA2 KRT31 KRT40 LIG4 LZTS2 NCF1 PRCC SCAF11 SNRNP70 SREK1 SRSF1 SRSF11 SRSF3 SRSF4 TCF4 TRA2B TRIM27 U2AF1 UBQLN4 YTHDC1 ZRANB2 ZRSR2
Entrez ID		57018	6427
HPRD ID		10814	02888
Ensembl ID			ENSG00000161547
Uniprot IDs		C9JPL0 Q9UK58	Q01130 Q53FN0
PDB IDs			2KN4 2LEA 2LEB 2LEC
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process RNA Processing RNA Splicing MRNA 3'-end Processing Regulation Of MRNA Processing Spliceosomal Complex Disassembly Histone H3-R2 Demethylation Histone H4-R3 Demethylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine RNA 3'-end Processing Cell Recognition Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Recognition Of Apoptotic Cell Regulation Of Nitrogen Compound Metabolic Process Neuron Remodeling RNA Metabolic Process Phagocytosis, Recognition Intracellular Transport Cellular Copper Ion Homeostasis Gene Expression Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle	RNA Splicing RNA Processing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Termination Of RNA Polymerase II Transcription Nitrogen Compound Metabolic Process Nuclear Export Spliceosomal Complex Assembly MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus Nucleocytoplasmic Transport Nuclear Transport MRNA 3'-end Processing Regulation Of MRNA Processing RNA 3'-end Processing MRNA Transport RNA Transport Cellular Macromolecular Complex Assembly RNA Localization Regulation Of MRNA Splicing, Via Spliceosome Ribonucleoprotein Complex Assembly Cell Cycle Regulation Of RNA Splicing Regulation Of Cell Cycle Cytoplasmic Transport Cellular Metabolic Process Mitotic Cell Cycle Cell Cycle Process Ribonucleoprotein Complex Biogenesis Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Intracellular Transport RNA Biosynthetic Process Mitotic Cell Cycle Process Negative Regulation Of Cell Cycle Cellular Component Assembly Positive Regulation Of MRNA Splicing, Via Spliceosome DNA Strand Elongation Involved In DNA Replication Cellular Localization DNA Strand Elongation Regulation Of Protein Export From Nucleus
Tagcloud ?		11q13 180k 3q25 alcohol cdkn2a clarified consumption corrected csmd1 cttn dcun1d1 exome fadd fhit hnscc hnsccs oncogenes oncosuppressors pik3ca preceding q qter scna scnas smoking tobacco tp53 tp63 trigger	asxl1 biologic clonal cmml created cytopenias dependence discern dysplasia entity extramedullary extrapolation focuses granulocyte hematologic identifies landscape macrophage makes malignancy monocytosis myelomonocytic ontology propensity scientific speculative supporting tools troublesome
Tagcloud (Difference) ?		11q13 180k 3q25 alcohol cdkn2a clarified consumption corrected csmd1 cttn dcun1d1 exome fadd fhit hnscc hnsccs oncogenes oncosuppressors pik3ca preceding q qter scna scnas smoking tobacco tp53 tp63 trigger	asxl1 biologic clonal cmml created cytopenias dependence discern dysplasia entity extramedullary extrapolation focuses granulocyte hematologic identifies landscape macrophage makes malignancy monocytosis myelomonocytic ontology propensity scientific speculative supporting tools troublesome
Tagcloud (Intersection) ?