ACKR3 and ATP13A2

Number of citations of the paper that reports this interaction (PubMedID 22645275)
53

Data Source:
BioGRID (two hybrid)

		ACKR3	ATP13A2
Description		atypical chemokine receptor 3	ATPase cation transporting 13A2
Image
GO Annotations	Cellular Component	Endosome Early Endosome Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Membrane Recycling Endosome	Autophagosome Membrane Lysosome Lysosomal Membrane Endosome Late Endosome Multivesicular Body Autophagosome Vesicle Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Late Endosome Membrane Vesicle Multivesicular Body Membrane Neuron Projection Neuronal Cell Body Lysosomal Lumen
	Molecular Function	G Protein-coupled Receptor Activity Scavenger Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding C-X-C Chemokine Binding	Nucleotide Binding Protein Binding ATP Binding Zinc Ion Binding Lipid Binding Polyamine Transmembrane Transporter Activity ABC-type Polyamine Transporter Activity P-type Ion Transporter Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Manganese Ion Binding Metal Ion Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding P-type Transmembrane Transporter Activity Cupric Ion Binding
	Biological Process	Angiogenesis Vasculogenesis Chemotaxis Immune Response Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Cell Population Proliferation Calcium-mediated Signaling Oculomotor Nerve Development Receptor Internalization Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Mesenchymal Stem Cell Migration	Intracellular Calcium Ion Homeostasis Intracellular Iron Ion Homeostasis Intracellular Zinc Ion Homeostasis Autophagy Lysosomal Transport Positive Regulation Of Gene Expression Regulation Of Mitochondrion Organization Regulation Of Macroautophagy Regulation Of Autophagosome Size Intracellular Monoatomic Cation Homeostasis Regulation Of Intracellular Protein Transport Monoatomic Ion Transmembrane Transport Cellular Response To Oxidative Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Secretion Lipid Homeostasis Protein Localization To Lysosome Autophagosome-lysosome Fusion Cellular Response To Manganese Ion Cellular Response To Zinc Ion Extracellular Exosome Biogenesis Monoatomic Cation Transmembrane Transport Regulation Of Protein Localization To Nucleus Polyamine Transmembrane Transport Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Exosomal Secretion Spermine Transmembrane Transport Regulation Of Chaperone-mediated Autophagy Autophagosome Organization Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Lysosomal Protein Catabolic Process
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Ion transport by P-type ATPases
Drugs
Diseases			Parkinson's disease (PD)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Disease progression in age-related macular degeneration ( 29346644) Heel bone mineral density ( 30598549) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	A body shape index ( 34021172) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 25429064 31562340 20189936) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 28552196 25673412 34021172) Intraocular pressure ( 29617998) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28552196 34021172) Waist-hip index ( 34021172)
Interacting Genes		2 interacting genes: ATP13A2 TP53	36 interacting genes: ACKR3 ATP5MC2 CCKBR CMTM6 COL1A1 CXCR4 CYGB DCAF7 EMC7 F2R FAM111B FAM8A1 FKBP8 FUNDC2 GPR21 HIPK1 ICAM2 LMAN2 LRP6 MEX3B MYCBP2 NPY1R NRXN1 OCA2 OSTC PCDHB10 PCMTD2 PDIA6 PSME3IP1 SEC61B SPCS2 TSPAN14 UBE2J2 VAMP2 WDR5B WDR83OS
Entrez ID		57007	23400
HPRD ID		09882	13677
Ensembl ID		ENSG00000144476	ENSG00000159363
Uniprot IDs		P25106	Q8N4D4 Q8NBS1 Q9NQ11
PDB IDs		6K3F 7SK3 7SK4 7SK5 7SK6 7SK7 7SK8 7SK9 8TII 8TIL 8TIN 8TIO 8VJ9	7FJM 7FJP 7FJQ 7M5V 7M5X 7M5Y 7N70 7N72 7N73 7N74 7N75 7N76 7N77 7N78 7VPI 7VPJ 7VPK 7VPL 8IEK 8IEL 8IEM 8IEN 8IEO 8IER 8IES
Enriched GO Terms of Interacting Partners?		Regulation Of Autophagy Of Mitochondrion Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Regulation Of Neuron Apoptotic Process Histone Deacetylase Regulator Activity Negative Regulation Of Pentose-phosphate Shunt Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Response To Actinomycin D T Cell Proliferation Involved In Immune Response Negative Regulation Of Helicase Activity Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of G1 To G0 Transition Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Autophagy Regulation Of Mitochondrion Organization Glial Cell Apoptotic Process Cellular Response To UV-C Negative Regulation Of Catabolic Process Germ Cell Nucleus Cellular Response To Actinomycin D Regulation Of Macroautophagy Regulation Of Autophagy ATP-dependent DNA/DNA Annealing Activity Response To Oxidative Stress Polyamine Transmembrane Transporter Activity Extracellular Vesicle Biogenesis Spermine Transport Extracellular Exosome Biogenesis P-type Ion Transporter Activity Negative Regulation Of Lysosomal Protein Catabolic Process P-type Transmembrane Transporter Activity Regulation Of Autophagosome Size Spermine Transmembrane Transport Cupric Ion Binding ABC-type Polyamine Transporter Activity B Cell Lineage Commitment Regulation Of Pentose-phosphate Shunt Mitochondrial DNA Repair Bone Marrow Development Stress-induced Premature Senescence Polyamine Transmembrane Transport Positive Regulation Of Cellular Component Biogenesis Regulation Of NADP Metabolic Process Negative Regulation Of MiRNA Processing Regulation Of Chaperone-mediated Autophagy Cellular Response To Manganese Ion	Membrane Positive Regulation Of Cytosolic Calcium Ion Concentration Endoplasmic Reticulum Membrane G Protein-coupled Receptor Activity Localization Within Membrane C-X-C Chemokine Receptor Activity Endoplasmic Reticulum Coreceptor Activity
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