SARM1 and TICAM2

Number of citations of the paper that reports this interaction (PubMedID 17258210)
0

Data Source:
BioGRID (protein complementation assay)

		SARM1	TICAM2
Description		sterile alpha and TIR motif containing 1	TIR domain containing adaptor molecule 2
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Microtubule Cell Surface Microtubule Cytoskeleton Axon Dendrite Neuromuscular Junction Protein-containing Complex Cell Projection Synapse Glutamatergic Synapse Extrinsic Component Of Synaptic Membrane	Phagocytic Cup Cytoplasm Endosome Early Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Secretory Granule Membrane Early Endosome Membrane Late Endosome Membrane Cell Projection
	Molecular Function	NAD+ Nucleosidase Activity Protein Binding Hydrolase Activity Signaling Adaptor Activity Identical Protein Binding NADP+ Nucleosidase Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating	Protein Binding Signaling Adaptor Activity Molecular Adaptor Activity
	Biological Process	Immune System Process Signal Transduction Nervous System Development Response To Glucose NAD+ Catabolic Process Cell Differentiation Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Innate Immune Response Response To Axon Injury Regulation Of Dendrite Morphogenesis Nervous System Process Protein Localization To Mitochondrion Modification Of Postsynaptic Structure Regulation Of Synapse Pruning	Immune System Process Phagocytosis Inflammatory Response Signal Transduction Positive Regulation Of Type I Interferon Production Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway TRAM-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Response To Other Organism Cellular Response To Lipopolysaccharide Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Interleukin-18-mediated Signaling Pathway
Pathways			Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF-mediated programmed cell death Neutrophil degranulation Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 27455348) Amyotrophic lateral sclerosis (sporadic) ( 28931804) Osteoprotegerin levels ( 25080503)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Response to antidepressants (symptom improvement) ( 29160301)
Interacting Genes		6 interacting genes: CCDC47 IRAK2 MYD88 NLRX1 STT3A TICAM2	19 interacting genes: FTH1 IL1R1 IL1RAP IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF7 MEOX2 NTAQ1 OPN1LW PIAS2 SARM1 TICAM1 TIRAP TLR3 TLR4 TRAF6
Entrez ID		23098	353376
HPRD ID		09664	16313
Ensembl ID		ENSG00000004139	ENSG00000243414
Uniprot IDs		Q05B42 Q0D2N8 Q6SZW1	Q86XR7
PDB IDs		6O0Q 6O0R 6O0S 6O0T 6O0U 6O0V 6O1B 6QWV 6WPK 6ZFX 6ZG0 6ZG1 7ANW 7CM5 7CM6 7CM7 7DJT 7KNQ 7LD0 7NAG 7NAH 7NAI 7NAJ 7NAK 7NAL 7QG0 8D0C 8D0D 8D0E 8D0F 8D0G 8D0H 8D0I 8D0J 8GNI 8GNJ 8GQ5 8P2L 9L2D 9L2E	2M1W 9DKI 9DLG
Enriched GO Terms of Interacting Partners?		Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Toll Signaling Pathway Signaling Adaptor Activity Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Regulation Of Type I Interferon Production MyD88-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Molecular Adaptor Activity Activation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Non-canonical NF-kappaB Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Regulation Of Macrophage Cytokine Production Regulation Of Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Endosome Membrane Positive Regulation Of Innate Immune Response Regulation Of Immune Response Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Chemokine Production Activation Of Immune Response Response To Interleukin-1 Positive Regulation Of Defense Response TIR Domain Binding Toll Binding ATP-dependent Histone Chaperone Activity Induced Systemic Resistance Positive Regulation Of Type I Interferon Production Phagocytosis Negative Regulation Of Canonical NF-kappaB Signal Transduction Defense Response Regulation Of Chemokine Production Inflammatory Response Oligosaccharyl Transferase Activity Toll-like Receptor 5 Signaling Pathway Regulation Of Cytokine Production Involved In Immune Response Regulation Of Immune System Process Response To Stress Innate Immune Response Toll-like Receptor 8 Signaling Pathway	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-1-mediated Signaling Pathway Immune Response-activating Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Regulation Of Defense Response Positive Regulation Of Immune Response Regulation Of Immune Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Type I Interferon Production Positive Regulation Of Cytokine Production Immune Response Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Toll Signaling Pathway Regulation Of Interferon-beta Production Endolysosomal Toll-like Receptor Signaling Pathway Interleukin-33-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Response To External Biotic Stimulus Regulation Of Interleukin-6 Production Defense Response TRIF-dependent Toll-like Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Response To Other Organism Endosome Membrane Positive Regulation Of Interferon-beta Production
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