SARM1 and TICAM2

Number of citations of the paper that reports this interaction (PMID 17258210)
8

Data Source:
BioGRID (protein complementation assay)

		SARM1	TICAM2
Gene Name		sterile alpha and TIR motif containing 1	toll-like receptor adaptor molecule 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Microtubule Cell Junction Axon Dendrite Extrinsic Component Of Mitochondrial Outer Membrane Synapse	Early Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Endosome Membrane Early Endosome Membrane Late Endosome Membrane
	Molecular Function		Signal Transducer Activity Phospholipid Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Response To Glucose Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Apoptotic Process Innate Immune Response Regulation Of Dendrite Morphogenesis Regulation Of Neuron Death	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway TRAM-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Response To Interleukin-12 Cellular Response To Lipopolysaccharide Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Interleukin-18-mediated Signaling Pathway
Pathways			Activated TLR4 signalling Toll-Like Receptors Cascades TRAF6 mediated induction of TAK1 complex IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade TRIF-mediated programmed cell death MyD88-independent cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CCDC47 GHITM IRAK2 MYD88 NLRX1 STT3A TICAM2	18 interactors: FTH1 IL1R1 IL1RAP IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF7 MEOX2 OPN1LW PIAS2 SARM1 TICAM1 TIRAP TLR3 TLR4 TRAF6
Entrez ID		23098	353376
HPRD ID		09664	16313
Ensembl ID		ENSG00000004139	ENSG00000243414
Uniprot IDs		Q05B42 Q0D2N8 Q6SZW1	Q86XR7
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Interleukin-6 Production Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Innate Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Biotic Stimulus Innate Immune Response Lipopolysaccharide-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Chemokine Production Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Chemokine Production I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-6 Production MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Lipid Inflammatory Response Immune Response-regulating Signaling Pathway Response To Interleukin-1 Immune Response Regulation Of Immune System Process JNK Cascade Response To Bacterium Positive Regulation Of Interleukin-18-mediated Signaling Pathway Defense Response Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Regulation Of Type I Interferon Production Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Co-translational Protein Modification Positive Regulation Of Immune Response	Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Interferon-beta Production Immune System Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Cytokine Stimulus Regulation Of I-kappaB Kinase/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Interferon-beta Production Regulation Of Immune System Process Cytokine-mediated Signaling Pathway Defense Response Cellular Response To Molecule Of Bacterial Origin Response To Cytokine Response To Other Organism Response To Bacterium Response To Biotic Stimulus Response To Lipopolysaccharide Lipopolysaccharide-mediated Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Organic Substance Response To Molecule Of Bacterial Origin Regulation Of Type I Interferon Production Regulation Of Interleukin-6 Production Regulation Of Cytokine Biosynthetic Process Cellular Response To Interleukin-1 Positive Regulation Of Interferon-alpha Production Cellular Response To Organic Substance Toll-like Receptor 9 Signaling Pathway
Tagcloud ?		affects allosteric ameliorates associative autism ca1 cdppb disrupt dysregulation flexibility impairs innate ltd metabotropic mglur mglur5 modulator morphogenesis neurodevelopmental nmdar players potentiation recording shank1 shank3 slice synaptic tlr toll	advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb tlr4 tlr6 tollip tuberculin uganda
Tagcloud (Difference) ?		affects allosteric ameliorates associative autism ca1 cdppb disrupt dysregulation flexibility impairs innate ltd metabotropic mglur mglur5 modulator morphogenesis neurodevelopmental nmdar players potentiation recording shank1 shank3 slice synaptic tlr toll	advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb tlr4 tlr6 tollip tuberculin uganda
Tagcloud (Intersection) ?