SARM1 and STT3A

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down)

		SARM1	STT3A
Gene Name		sterile alpha and TIR motif containing 1	STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Microtubule Cell Junction Axon Dendrite Extrinsic Component Of Mitochondrial Outer Membrane Synapse	Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Integral Component Of Membrane
	Molecular Function		Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Response To Glucose Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Apoptotic Process Innate Immune Response Regulation Of Dendrite Morphogenesis Regulation Of Neuron Death	Protein N-linked Glycosylation Via Asparagine Co-translational Protein Modification Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective MOGS causes MOGS-CDG (CDG-2b) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Defective ALG11 causes ALG11-CDG (CDG-1p)
Drugs
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Schizophrenia ( 21926974)
Protein-Protein Interactions		7 interactors: CCDC47 GHITM IRAK2 MYD88 NLRX1 STT3A TICAM2	6 interactors: CSDE1 HJURP IRAK2 ITM2C SARM1 TMEM173
Entrez ID		23098	3703
HPRD ID		09664	03086
Ensembl ID		ENSG00000004139	ENSG00000134910
Uniprot IDs		Q05B42 Q0D2N8 Q6SZW1	B4DJ24 E9PNQ1 P46977
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Interleukin-6 Production Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Innate Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Biotic Stimulus Innate Immune Response Lipopolysaccharide-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Chemokine Production Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Chemokine Production I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-6 Production MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Lipid Inflammatory Response Immune Response-regulating Signaling Pathway Response To Interleukin-1 Immune Response Regulation Of Immune System Process JNK Cascade Response To Bacterium Positive Regulation Of Interleukin-18-mediated Signaling Pathway Defense Response Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Regulation Of Type I Interferon Production Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Co-translational Protein Modification Positive Regulation Of Immune Response	Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Innate Immune Response Nuclear-transcribed MRNA Catabolic Process, No-go Decay Regulation Of Immune Response Interferon-beta Production Positive Regulation Of Immune System Process Regulation Of Binding Cellular Response To Exogenous DsRNA Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Interferon-beta Regulation Of Neuron Projection Development Type I Interferon Production Positive Regulation Of Defense Response To Virus By Host Interleukin-1-mediated Signaling Pathway Regulation Of Protein Import Into Nucleus, Translocation Response To Interferon-beta Immune Response-regulating Signaling Pathway Regulation Of Cell Projection Organization Nucleotide-binding Oligomerization Domain Containing Signaling Pathway CENP-A Containing Nucleosome Assembly Regulation Of Neuron Differentiation Regulation Of Defense Response To Virus By Host
Tagcloud ?		affects allosteric ameliorates associative autism ca1 cdppb disrupt dysregulation flexibility impairs innate ltd metabotropic mglur mglur5 modulator morphogenesis neurodevelopmental nmdar players potentiation recording shank1 shank3 slice synaptic tlr toll	acceptor accessory allowed asparagine biosynthetic catalytic cotranslational cysteine duplication evolve folding glycosylated glycosylation magt1 maximize mediating metazoan oligosaccharides oligosaccharyltransferase organisms ost oxidoreductase posttranslocational progress sequentially skipped stt3b summarize traffic
Tagcloud (Difference) ?		affects allosteric ameliorates associative autism ca1 cdppb disrupt dysregulation flexibility impairs innate ltd metabotropic mglur mglur5 modulator morphogenesis neurodevelopmental nmdar players potentiation recording shank1 shank3 slice synaptic tlr toll	acceptor accessory allowed asparagine biosynthetic catalytic cotranslational cysteine duplication evolve folding glycosylated glycosylation magt1 maximize mediating metazoan oligosaccharides oligosaccharyltransferase organisms ost oxidoreductase posttranslocational progress sequentially skipped stt3b summarize traffic
Tagcloud (Intersection) ?