SARM1 and NLRX1

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SARM1	NLRX1
Description		sterile alpha and TIR motif containing 1	NLR family member X1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Microtubule Cell Surface Microtubule Cytoskeleton Axon Dendrite Neuromuscular Junction Protein-containing Complex Cell Projection Synapse Glutamatergic Synapse Extrinsic Component Of Synaptic Membrane	Mitochondrion Mitochondrial Outer Membrane Cytosol Plasma Membrane Membrane
	Molecular Function	NAD+ Nucleosidase Activity Protein Binding Hydrolase Activity Signaling Adaptor Activity Identical Protein Binding NADP+ Nucleosidase Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating	Nucleotide Binding Protein Binding ATP Binding
	Biological Process	Immune System Process Signal Transduction Nervous System Development Response To Glucose NAD+ Catabolic Process Cell Differentiation Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Innate Immune Response Response To Axon Injury Regulation Of Dendrite Morphogenesis Nervous System Process Protein Localization To Mitochondrion Modification Of Postsynaptic Structure Regulation Of Synapse Pruning	Immune System Process Negative Regulation Of Macrophage Cytokine Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Inflammatory Response
Pathways			DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling Regulation of NF-kappa B signaling
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 27455348) Amyotrophic lateral sclerosis (sporadic) ( 28931804) Osteoprotegerin levels ( 25080503)	Mean reticulocyte volume ( 32888494)
Interacting Genes		6 interacting genes: CCDC47 IRAK2 MYD88 NLRX1 STT3A TICAM2	1 interacting genes: SARM1
Entrez ID		23098	79671
HPRD ID		09664	17640
Ensembl ID		ENSG00000004139	ENSG00000160703
Uniprot IDs		Q05B42 Q0D2N8 Q6SZW1	A0A9L9PX86 Q86UT6
PDB IDs		6O0Q 6O0R 6O0S 6O0T 6O0U 6O0V 6O1B 6QWV 6WPK 6ZFX 6ZG0 6ZG1 7ANW 7CM5 7CM6 7CM7 7DJT 7KNQ 7LD0 7NAG 7NAH 7NAI 7NAJ 7NAK 7NAL 7QG0 8D0C 8D0D 8D0E 8D0F 8D0G 8D0H 8D0I 8D0J 8GNI 8GNJ 8GQ5 8P2L 9L2D 9L2E	3UN9
Enriched GO Terms of Interacting Partners?		Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Toll Signaling Pathway Signaling Adaptor Activity Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Regulation Of Type I Interferon Production MyD88-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Molecular Adaptor Activity Activation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Non-canonical NF-kappaB Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Regulation Of Macrophage Cytokine Production Regulation Of Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Endosome Membrane Positive Regulation Of Innate Immune Response Regulation Of Immune Response Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Chemokine Production Activation Of Immune Response Response To Interleukin-1 Positive Regulation Of Defense Response TIR Domain Binding Toll Binding ATP-dependent Histone Chaperone Activity Induced Systemic Resistance Positive Regulation Of Type I Interferon Production Phagocytosis Negative Regulation Of Canonical NF-kappaB Signal Transduction Defense Response Regulation Of Chemokine Production Inflammatory Response Oligosaccharyl Transferase Activity Toll-like Receptor 5 Signaling Pathway Regulation Of Cytokine Production Involved In Immune Response Regulation Of Immune System Process Response To Stress Innate Immune Response Toll-like Receptor 8 Signaling Pathway	NADP+ Nucleosidase Activity Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Extrinsic Component Of Synaptic Membrane NAD+ Nucleosidase Activity Negative Regulation Of Growth Rate Guanylate Cyclase Inhibitor Activity RES Complex Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway NAD+ Catabolic Process ABC-type Sterol Transporter Activity
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