PAK6 and SNX2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PAK6	SNX2
Gene Name		p21 protein (Cdc42/Rac)-activated kinase 6	sorting nexin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Endosome Membrane Membrane Extrinsic Component Of Membrane Lamellipodium Retromer Complex Early Endosome Membrane Intracellular Membrane-bounded Organelle Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Transferrin Receptor Binding Leptin Receptor Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Signal Transduction By Phosphorylation Intracellular Signal Transduction	Intracellular Protein Transport Endocytosis Vesicle Organization Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Protein Oligomerization Lamellipodium Morphogenesis
Pathways		Axon guidance Activation of Rac Signaling by Robo receptor	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: AKT1 APP AR CDC42 CDK1 ESR1 MAPK14 MDM2 NEK6 RHOJ SEMA3B SNX2 TPD52L1	20 interactors: ACVR1B ACVR2B C1orf122 CSNK2B DUSP10 EGFR FNBP1 INSR LAMC1 LEPR MET NFYC PAK6 PDGFRA PDGFRB SNX1 SNX4 SNX5 SNX6 ZNF202
Entrez ID		56924	6643
HPRD ID		06426	09332
Ensembl ID		ENSG00000137843	ENSG00000205302
Uniprot IDs		B3KYB0 G5E9R2 Q9NQU5	B4DEK4 B7Z408 O60749
PDB IDs		2C30 2ODB 4KS7 4KS8
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Transport Vascular Endothelial Growth Factor Receptor Signaling Pathway Apoptotic Process Positive Regulation Of Cell Cycle Positive Regulation Of Gene Expression Programmed Cell Death Peptidyl-serine Phosphorylation Cell Death Death Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Establishment Of Protein Localization Positive Regulation Of Cellular Metabolic Process DNA Damage Checkpoint Regulation Of Protein Kinase Activity Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction ERBB Signaling Pathway Regulation Of Mitotic Cell Cycle Regulation Of Protein Localization Regulation Of Kinase Activity Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Innate Immune Response Regulation Of Intracellular Transport Positive Regulation Of Cell Proliferation Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Phosphorylation Immune Response-regulating Signaling Pathway Regulation Of Cell Cycle Process Regulation Of Apoptotic Process Positive Regulation Of Kinase Activity Growth Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Neurotrophin Signaling Pathway Positive Regulation Of Catalytic Activity Cell Cycle Checkpoint Regulation Of Cell Death Signaling Positive Regulation Of Cellular Biosynthetic Process	Regulation Of Kinase Activity Protein Autophosphorylation Regulation Of Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Signal Transduction By Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Regulation Of Cell Migration Positive Regulation Of Locomotion Protein Phosphorylation Regulation Of Cell Motility Phosphorylation Regulation Of Signaling Retina Vasculature Development In Camera-type Eye Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Metanephric Glomerular Capillary Formation Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Peptidyl-tyrosine Phosphorylation Tissue Development Positive Regulation Of Signal Transduction Regulation Of MAP Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Chemotaxis Positive Regulation Of DNA Metabolic Process Digestive System Development Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Glomerular Capillary Formation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Cellular Protein Metabolic Process Retrograde Transport, Endosome To Golgi Tube Morphogenesis Endosomal Transport Metanephric Glomerulus Vasculature Development Digestive Tract Morphogenesis
Tagcloud ?		19a 19b1 5p apaf1 beclin1 daci exerts favor hep3b hepg2 hsa impedance inc interfere lbh589 mentioned mimicking mir30a mirna mirnas oligonucleotides oncomirs panobinostat periodicals proving qpcr restoring transfecting wiley	assembles assembling autonomously cation comprises conflicting endosomal endosomes heterodimer heterotrimer homodimer interchangeable mammalian mannose named nexin obligate performing retrieval retromer retromers snx1 sorting subcomplexes tgn truly vps26 vps29 vps35
Tagcloud (Difference) ?		19a 19b1 5p apaf1 beclin1 daci exerts favor hep3b hepg2 hsa impedance inc interfere lbh589 mentioned mimicking mir30a mirna mirnas oligonucleotides oncomirs panobinostat periodicals proving qpcr restoring transfecting wiley	assembles assembling autonomously cation comprises conflicting endosomal endosomes heterodimer heterotrimer homodimer interchangeable mammalian mannose named nexin obligate performing retrieval retromer retromers snx1 sorting subcomplexes tgn truly vps26 vps29 vps35
Tagcloud (Intersection) ?