PAK6 and RHOV

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PAK6	RHOV
Description		p21 (RAC1) activated kinase 6	ras homolog family member V
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Cell Junction	Endosome Plasma Membrane Endosome Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cadherin Binding Protein Serine Kinase Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Cellular Response To Starvation Intracellular Signal Transduction Regulation Of MAPK Cascade Neuron Projection Arborization Neuron Projection Extension	Endocytosis Cytoskeleton Organization Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Establishment Of Cell Polarity
Pathways		Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle RHOV GTPase cycle	RHOV GTPase cycle
Drugs		Fostamatinib
Diseases
GWAS		Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)	Malaria ( 31844061) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		19 interacting genes: APP AR CDC42 CDK1 DAPK1 ESR1 FBXO7 HSF2BP LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RHOJ RHOV SEMA3B SNX2 TPD52L1	1 interacting genes: PAK6
Entrez ID		56924	171177
HPRD ID		06426	10191
Ensembl ID		ENSG00000137843	ENSG00000104140
Uniprot IDs		Q9NQU5	Q96L33
PDB IDs		2C30 2ODB 4KS7 4KS8 6QDR 6QDS
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Anatomical Structure Morphogenesis Developmental Process Cellular Response To Estrogen Stimulus Protein Kinase Binding Supramolecular Fiber Organization Regulation Of Mitotic Cell Cycle Protein-containing Complex Protein Serine Kinase Activity Glutamatergic Synapse Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Cell Communication Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Developmental Growth Involved In Morphogenesis Regulation Of Developmental Process Regulation Of Developmental Growth Regulation Of Intracellular Signal Transduction Estrogen Response Element Binding Prostate Gland Growth Response To Estrogen Mitotic Nuclear Membrane Disassembly Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Cell Cycle Process Protein Kinase Activity Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Cycle Cellular Developmental Process Regulation Of Locomotion Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Kinetochore Regulation Of Reproductive Process Positive Regulation Of Cell Migration Developmental Growth Regulation Of Growth Regulation Of MiRNA Transcription Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Reproductive Process Membrane Disassembly Nuclear Membrane Disassembly Leukocyte Differentiation GTP Binding Cell-cell Signaling Cellular Response To Oxygen-containing Compound Regulation Of Apoptotic Signaling Pathway
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