POLK and REV1

Number of citations of the paper that reports this interaction (PubMedID 19170759)
29

Data Source:
HPRD (in vitro)

		POLK	REV1
Description		DNA polymerase kappa	REV1 DNA directed polymerase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Site Of DNA Damage	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity DNA Polymerase Activity Metal Ion Binding	DNA Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Transferase Activity Nucleotidyltransferase Activity Deoxycytidyl Transferase Activity Metal Ion Binding
	Biological Process	DNA Replication DNA Repair Nucleotide-excision Repair, DNA Gap Filling DNA Damage Response Cellular Response To UV Error-prone Translesion Synthesis DNA Biosynthetic Process	DNA Metabolic Process DNA Replication DNA Repair DNA Damage Response Response To UV Error-prone Translesion Synthesis Error-free Translesion Synthesis DNA Biosynthetic Process
Pathways		Translesion synthesis by POLK Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER	Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis
Drugs		1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE 1-[2-DEOXYRIBOFURANOSYL]-2,4-DIFLUORO-5-METHYL-BENZENE-5'MONOPHOSPHATE 2'-deoxy-N-(naphthalen-1-ylmethyl)guanosine 5'-(dihydrogen phosphate)
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634)	Bipolar disorder ( 21926972)
Interacting Genes		5 interacting genes: PCNA RAD18 REV1 TRAIP WRN	13 interacting genes: CLK1 FAAP20 FHL2 MAD2L2 POLD3 POLDIP2 POLH POLI POLK POLL REV3L TSC22D2 UBC
Entrez ID		51426	51455
HPRD ID		09291	16202
Ensembl ID		ENSG00000122008	ENSG00000135945
Uniprot IDs		Q9UBT6	Q49AI5 Q9UBZ9
PDB IDs		1T94 2LSI 2OH2 2W7O 2W7P 3IN5 3PZP 4BA9 4GK5 4U6P 4U7C 5T14 5W2A 5W2C 6BRX 6BS1 6CST 7NV0 7NV1	2EBW 2LSI 2LSK 2LSY 2N1G 3GQC 3VU7 4BA9 4EXT 4GK0 4GK5 5VZM 6ASR 6AXD 6WS0 6WS5
Enriched GO Terms of Interacting Partners?		Replication Fork DNA Repair Replication Fork Processing DNA Metabolic Process DNA Synthesis Involved In DNA Repair Postreplication Repair DNA Damage Response Y-form DNA Binding Damaged DNA Binding DNA Biosynthetic Process MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Cellular Response To Stress DNA Replication Response To UV Translesion Synthesis Nucleic Acid Metabolic Process Mismatch Repair Response To Light Stimulus Nucleobase-containing Compound Metabolic Process Protein-containing Complex Binding Response To Radiation Response To Stress PCNA Complex Replisome Positive Regulation Of Strand Invasion 3'-flap-structured DNA Binding Deoxycytidyl Transferase Activity Rad6-Rad18 Complex Telomere Maintenance PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Centrosome Telomere Organization Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Forked DNA-dependent Helicase Activity Chromosome Nucleoplasm Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Cellular Response To Radiation DNA Binding Chromosome, Telomeric Region Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Telomeric D-loop Binding Catalytic Activity, Acting On DNA Nucleobase-containing Compound Biosynthetic Process	Translesion Synthesis Postreplication Repair DNA Synthesis Involved In DNA Repair DNA Biosynthetic Process Error-prone Translesion Synthesis DNA-directed DNA Polymerase Activity DNA Polymerase Activity DNA Repair DNA Metabolic Process DNA Replication DNA Damage Response Zeta DNA Polymerase Complex Nucleobase-containing Compound Biosynthetic Process Nucleotidyltransferase Activity Macromolecule Biosynthetic Process Cellular Response To Stress Nucleic Acid Metabolic Process Error-free Translesion Synthesis Nucleotide-excision Repair, DNA Gap Filling Damaged DNA Binding Response To Stress Nucleobase-containing Compound Metabolic Process Site Of Double-strand Break Nucleoplasm Nucleus Somatic Diversification Of Immunoglobulins Double-strand Break Repair DNA-templated DNA Replication DNA Damage Response, Signal Transduction Resulting In Transcription Macromolecule Metabolic Process Transferase Activity Atrial Cardiac Muscle Cell Development Cellular Response To UV DNA Synthesis Involved In UV-damage Excision Repair Delta DNA Polymerase Complex Cellular Response To Light Stimulus Cellular Response To UV-C DNA Binding Vascular Associated Smooth Muscle Cell Proliferation
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