POLK

Description		DNA polymerase kappa
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Site Of DNA Damage
	Molecular Function	DNA Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity DNA Polymerase Activity Metal Ion Binding
	Biological Process	DNA Replication DNA Repair Nucleotide-excision Repair, DNA Gap Filling DNA Damage Response Cellular Response To UV Error-prone Translesion Synthesis DNA Biosynthetic Process
Pathways		Translesion synthesis by POLK Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs		1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE 1-[2-DEOXYRIBOFURANOSYL]-2,4-DIFLUORO-5-METHYL-BENZENE-5'MONOPHOSPHATE 2'-deoxy-N-(naphthalen-1-ylmethyl)guanosine 5'-(dihydrogen phosphate)
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634)
Interacting Genes		5 interacting genes: PCNA RAD18 REV1 TRAIP WRN
Entrez ID		51426
HPRD ID		09291
Ensembl ID		ENSG00000122008
Uniprot IDs		Q9UBT6
PDB IDs		1T94 2LSI 2OH2 2W7O 2W7P 3IN5 3PZP 4BA9 4GK5 4U6P 4U7C 5T14 5W2A 5W2C 6BRX 6BS1 6CST 7NV0 7NV1
Enriched GO Terms of Interacting Partners?		Replication Fork DNA Repair Replication Fork Processing DNA Metabolic Process DNA Synthesis Involved In DNA Repair Postreplication Repair DNA Damage Response Y-form DNA Binding Damaged DNA Binding DNA Biosynthetic Process MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Cellular Response To Stress DNA Replication Response To UV Translesion Synthesis Nucleic Acid Metabolic Process Mismatch Repair Response To Light Stimulus Nucleobase-containing Compound Metabolic Process Protein-containing Complex Binding Response To Radiation Response To Stress PCNA Complex Replisome Positive Regulation Of Strand Invasion 3'-flap-structured DNA Binding Deoxycytidyl Transferase Activity Rad6-Rad18 Complex Telomere Maintenance PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Centrosome Telomere Organization Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Forked DNA-dependent Helicase Activity Chromosome Nucleoplasm Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Cellular Response To Radiation DNA Binding Chromosome, Telomeric Region Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Telomeric D-loop Binding Catalytic Activity, Acting On DNA Nucleobase-containing Compound Biosynthetic Process
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