POLK and RAD18

Number of citations of the paper that reports this interaction (PMID 21396873)
21

Data Source:
BioGRID (affinity chromatography technology, pull down)

		POLK	RAD18
Gene Name		polymerase (DNA directed) kappa	RAD18 E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Chromatin XY Body Nucleus Replication Fork
	Molecular Function	Damaged DNA Binding DNA-directed DNA Polymerase Activity Metal Ion Binding	Y-form DNA Binding Damaged DNA Binding Protein Binding Zinc Ion Binding Ligase Activity Polyubiquitin Binding Ubiquitin Protein Ligase Binding
	Biological Process	DNA Replication DNA Repair Nucleotide-excision Repair, DNA Gap Filling DNA Biosynthetic Process	DNA Repair Spermatogenesis Response To UV Protein Ubiquitination Negative Regulation Of DNA Recombination
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: RAD18 REV1 TRAIP	21 interactors: DZIP3 MAPK8 MLKL NBN PCGF6 PCNA POLK RAD51 RFC2 SHPRH SIVA1 TAX1BP1 TP53BP1 TRIM23 TRIM8 TSG101 UBC UBE2A UBE2B UBE2I USP2
Entrez ID		51426	56852
HPRD ID		09291	09242
Ensembl ID			ENSG00000070950
Uniprot IDs		Q9UBT6	Q9NS91
PDB IDs		1T94 2LSI 2OH2 2W7O 2W7P 3IN5 3PZP 4BA9 4GK5	2Y43 2YBF
Enriched GO Terms of Interacting Partners?		Response To UV Error-prone Translesion Synthesis Response To Light Stimulus Response To Radiation Translesion Synthesis Protein Ubiquitination DNA Repair Protein Modification By Small Protein Conjugation Negative Regulation Of DNA Recombination Postreplication Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Response To Abiotic Stimulus Regulation Of DNA Recombination	DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Stress Protein Ubiquitination Protein Modification By Small Protein Conjugation DNA Recombination Protein Polyubiquitination Nucleotide-excision Repair, DNA Gap Filling Response To Stress Postreplication Repair Cell Cycle Cell Cycle Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mitotic Recombination Proteasomal Protein Catabolic Process Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Protein Catabolic Process Chromosome Organization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of RNA Biosynthetic Process Response To Radiation Viral Protein Processing Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Transcription, DNA-templated Cellular Macromolecule Catabolic Process Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Nucleotide-excision Repair Histone H2A Ubiquitination Negative Regulation Of Gene Expression DNA Replication Regulation Of RNA Metabolic Process Viral Process Negative Regulation Of Biosynthetic Process Response To Stimulus DNA-dependent DNA Replication Telomere Maintenance Via Semi-conservative Replication Programmed Cell Death Regulation Of Metabolic Process
Tagcloud ?		affordable brought collaboration collaborative community contributed convened coordinated county department drew emphasized engaged engagement forums goals meaningful mid organizations orientation priorities rural serving sharply surveys top ultimately wisconsin workgroups	break camptothecin chemotherapeutic collaboratively conjugating doi dsb dsbs dt40 hypersensitivity joining ku70 ligases nhej nonhomologous olaparib onc operate poison polymerization promotion publication rad51 rays recombinase repaired rnf8 topoisomerase ubc13
Tagcloud (Difference) ?		affordable brought collaboration collaborative community contributed convened coordinated county department drew emphasized engaged engagement forums goals meaningful mid organizations orientation priorities rural serving sharply surveys top ultimately wisconsin workgroups	break camptothecin chemotherapeutic collaboratively conjugating doi dsb dsbs dt40 hypersensitivity joining ku70 ligases nhej nonhomologous olaparib onc operate poison polymerization promotion publication rad51 rays recombinase repaired rnf8 topoisomerase ubc13
Tagcloud (Intersection) ?