MAGEA4 and LDLRAP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAGEA4	LDLRAP1
Description		MAGE family member A4	low density lipoprotein receptor adaptor protein 1
Image
GO Annotations	Cellular Component	Nucleus	Cytoplasm Early Endosome Cytosol Neurofilament Plasma Membrane Cytoplasmic Side Of Plasma Membrane Basal Plasma Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Recycling Endosome
	Molecular Function	Protein Binding Histone Deacetylase Binding	Amyloid-beta Binding Phosphotyrosine Residue Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Signaling Receptor Complex Adaptor Activity Clathrin Binding Signaling Adaptor Activity AP-2 Adaptor Complex Binding Clathrin Adaptor Activity AP-1 Adaptor Complex Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Cycle	Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Steroid Metabolic Process Cholesterol Metabolic Process Cholesterol Transport Receptor Internalization Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Amyloid Precursor Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Receptor-mediated Endocytosis Cellular Response To Cytokine Stimulus Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
Pathways			Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chylomicron clearance LDL clearance Transport of RCbl within the body
Drugs
Diseases
GWAS			Cholesterol, total ( 20686565 24097068 25961943) LDL cholesterol ( 20686565 24097068 25961943) LDL cholesterol levels ( 28334899) Mean platelet volume ( 27863252 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Total cholesterol levels ( 28334899)
Interacting Genes		27 interacting genes: AMOT AMOTL2 APP ARNT2 BEX2 COX8A GTF3C1 HDDC3 HLA-A LDLRAP1 PICK1 POT1 PSMD10 PUDP RAD18 TEKT4 TIGD5 TK1 TRIM69 TSPYL1 TSPYL4 TXN2 UBXN6 UQCRB UVSSA WBP2 ZNF576	18 interacting genes: AP1B1 AP2B1 APP C6orf58 CLTC ESPNL FHL2 HOXC8 HOXD8 LDLR LRP2 MAGEA4 MAPK8IP3 NOTO PAX5 PSD4 SNCA TFAP2A
Entrez ID		4103	26119
HPRD ID		02167	05765
Ensembl ID		ENSG00000147381	ENSG00000157978
Uniprot IDs		P43358	B3KR97 Q5SW96
PDB IDs		1I4F 2WA0 6TRN 6TRO 7UOA 8ES8 8ES9 8FJA 9BD3	2G30
Enriched GO Terms of Interacting Partners?		Establishment Of Cell Polarity Involved In Ameboidal Cell Migration	Clathrin-coated Pit Endolysosome Membrane Clathrin-coated Endocytic Vesicle Membrane Receptor-mediated Endocytosis Negative Regulation Of Transcription By RNA Polymerase II Amyloid-beta Clearance Endocytosis Skeletal System Morphogenesis Vesicle-mediated Transport Positive Regulation Of Lysosomal Protein Catabolic Process Artery Development Clathrin Coat Kidney Development Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Import Into Cell Negative Regulation Of RNA Metabolic Process Pattern Specification Process Receptor Internalization Anatomical Structure Morphogenesis Regulation Of Lysosomal Protein Catabolic Process Clathrin Adaptor Complex Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Lysosome Low-density Lipoprotein Particle Low-density Lipoprotein Particle Receptor Activity Negative Regulation Of Metabolic Process Regulation Of Amyloid Fibril Formation Regionalization Transcytosis Negative Regulation Of Apoptotic Process Trans-Golgi Network Membrane Clathrin Coat Assembly Regulation Of Neurotransmitter Uptake Negative Regulation Of Programmed Cell Death Developmental Process Endosome Lumen Clathrin-coated Endocytic Vesicle Cellular Response To Copper Ion Regulation Of Receptor Recycling Coronary Vasculature Development Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Low-density Lipoprotein Particle Receptor Binding Regulation Of Presynapse Assembly Synaptic Vesicle
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?