RETN and GPR25

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RETN	GPR25
Description		resistin	G protein-coupled receptor 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome	Plasma Membrane Membrane
	Molecular Function	Hormone Activity Protein Binding	G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Signal Transduction Response To Mechanical Stimulus Response To Insulin Fat Cell Differentiation Positive Regulation Of Synaptic Transmission Negative Regulation Of Feeding Behavior Positive Regulation Of Progesterone Secretion	Signal Transduction G Protein-coupled Receptor Signaling Pathway
Pathways		Neutrophil degranulation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	G alpha (s) signalling events
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Menarche (age at onset) ( 25231870) Resistin levels ( 22843503 24123702 27664181 32876488)	Ankylosing spondylitis ( 23749187) Autoimmune thyroid disease ( 32581359) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: A2M GPR25 SF3A2	32 interacting genes: AQP6 ATP6V0C ATP6V0E1 BEST2 CNIH4 CREB3L1 CREB3L3 FATE1 GGT7 GJB1 IKBIP KASH5 LDLRAD1 LMNA MAP3K7 MMGT1 NAALADL2 PNMA1 RETN RHCG SHISAL1 SLC16A7 SLC35E3 SLC61A1 SLCO4A1 STOM TMEM237 TMEM248 TMEM52B TPRA1 TSPAN12 VAPB
Entrez ID		56729	2848
HPRD ID		05714	03707
Ensembl ID		ENSG00000104918	ENSG00000170128
Uniprot IDs		Q9HD89	O00155
PDB IDs
Enriched GO Terms of Interacting Partners?		Interleukin-8 Binding Negative Regulation Of Complement Activation, Lectin Pathway Tumor Necrosis Factor Binding Interleukin-1 Binding MRNA 3'-splice Site Recognition Negative Regulation Of Complement Activation U2-type Prespliceosome Regulation Of Complement Activation U2-type Prespliceosome Assembly U2-type Spliceosomal Complex U2 SnRNP MRNA Splice Site Recognition Growth Factor Binding Regulation Of Humoral Immune Response Endopeptidase Inhibitor Activity Spliceosomal Complex Assembly U2-type Precatalytic Spliceosome	Membrane Carbon Dioxide Transmembrane Transporter Activity Transmembrane Transport Carbon Dioxide Transmembrane Transport Ammonium Transmembrane Transport Ammonium Channel Activity Proton-transporting V-type ATPase, V0 Domain Host-mediated Activation Of Viral Genome Replication Endoplasmic Reticulum Membrane Host-mediated Perturbation Of Viral Genome Replication Carbon Dioxide Transport Protein Binding Proton-transporting V-type ATPase Complex Response To Unfolded Protein Intracellular Monoatomic Ion Homeostasis Proton-transporting ATPase Activity, Rotational Mechanism Regulation Of PH One-carbon Compound Transport Basolateral Plasma Membrane Monoatomic Ion Transport
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