PSD and GNB5

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		PSD	GNB5
Gene Name		pleckstrin and Sec7 domain containing	guanine nucleotide binding protein (G protein), beta 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Trans-Golgi Network Plasma Membrane Integral Component Of Membrane Cell Junction	Nucleus Plasma Membrane
	Molecular Function	Signal Transducer Activity ARF Guanyl-nucleotide Exchange Factor Activity Protein Binding Phospholipid Binding	GTPase Activity Signal Transducer Activity Protein Binding G-protein Gamma-subunit Binding Chaperone Binding
	Biological Process	Signal Transduction Vesicle-mediated Transport Neuron Differentiation Regulation Of ARF Protein Signal Transduction Positive Regulation Of GTPase Activity	Signal Transduction Phototransduction, Visible Light Metabolic Process Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity
Pathways			G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Glucagon-type ligand receptors Signal amplification Signaling by Wnt G beta:gamma signalling through PLC beta Metabolic disorders of biological oxidation enzymes G beta:gamma signalling through PI3Kgamma Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (12/13) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Class B/2 (Secretin family receptors) ADP signalling through P2Y purinoceptor 12 Prostacyclin signalling through prostacyclin receptor G-protein beta:gamma signalling Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Activation of Kainate Receptors upon glutamate binding GPCR ligand binding Aquaporin-mediated transport beta-catenin independent WNT signaling Adrenaline,noradrenaline inhibits insulin secretion Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events Presynaptic function of Kainate receptors GPCR downstream signaling Platelet homeostasis Ca2+ pathway G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		5 interactors: GLRA2 GMFG GNB5 HEXDC RAB40C	26 interactors: ANXA7 APP BNIP3L CDKN1A CSNK2B E2F2 EIF3J GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNGT1 MCM2 MVD NR6A1 OLFM2 PSD PSMD4 RGS11 RGS6 RGS7 RGS9 RPA1 TSC22D1
Entrez ID		5662	10681
HPRD ID		09085	09191
Ensembl ID		ENSG00000059915	ENSG00000069966
Uniprot IDs		A5PKW4 Q86YI3	B3KWS4 O14775
PDB IDs
Enriched GO Terms of Interacting Partners?			Cellular Response To Glucagon Stimulus Response To Glucagon Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Response To Hormone Cellular Response To Stimulus Signal Transduction Cellular Response To Hormone Stimulus Signaling Cell Communication Response To Stimulus Regulation Of Cellular Process Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Organic Substance Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Signal Transduction Cellular Response To Organic Substance Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Response To Organonitrogen Compound G1/S Transition Of Mitotic Cell Cycle Synaptic Transmission Regulation Of Signaling Mitotic Cell Cycle Cellular Response To Light Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Signal Transduction By P53 Class Mediator Regulation Of Metabolic Process Cell-cell Signaling Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Metabolic Process Response To Light Stimulus DNA Strand Elongation Involved In DNA Replication Cellular Process Cellular Response To Radiation Apoptotic Process DNA Strand Elongation Small Molecule Metabolic Process Rhodopsin Mediated Signaling Pathway
Tagcloud ?		2a ablation able autophosphorylation back calmodulin camkii confined developmentally facilitation hippocampal hippocampus implication ltp mam methylazoxymethanol phosphatases plasticity postsynaptic potentiation preincubation presynaptic rats restore slices subserves synapses synaptic unchanged
Tagcloud (Difference) ?		2a ablation able autophosphorylation back calmodulin camkii confined developmentally facilitation hippocampal hippocampus implication ltp mam methylazoxymethanol phosphatases plasticity postsynaptic potentiation preincubation presynaptic rats restore slices subserves synapses synaptic unchanged
Tagcloud (Intersection) ?