PSD and HEXDC

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PSD	HEXDC
Gene Name		pleckstrin and Sec7 domain containing	hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Trans-Golgi Network Plasma Membrane Integral Component Of Membrane Cell Junction	Nucleus Cytoplasm
	Molecular Function	Signal Transducer Activity ARF Guanyl-nucleotide Exchange Factor Activity Protein Binding Phospholipid Binding	Beta-N-acetylhexosaminidase Activity
	Biological Process	Signal Transduction Vesicle-mediated Transport Neuron Differentiation Regulation Of ARF Protein Signal Transduction Positive Regulation Of GTPase Activity	Carbohydrate Metabolic Process
Pathways
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		5 interactors: GLRA2 GMFG GNB5 HEXDC RAB40C	9 interactors: ADPRHL2 C7orf25 EEF1D GDPD2 GLRX3 PARK2 PSD RILPL2 TUBB3
Entrez ID		5662	284004
HPRD ID		09085	08677
Ensembl ID		ENSG00000059915	ENSG00000169660
Uniprot IDs		A5PKW4 Q86YI3	Q8WVB3
PDB IDs
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Positive Regulation Of Protein Linear Polyubiquitination Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Manganese Ion Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Mitochondrial Fusion Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Fusion Negative Regulation Of Glucokinase Activity Neuron Cellular Homeostasis Positive Regulation Of Oxidative Stress-induced Cell Death Protein K6-linked Ubiquitination Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrion Degradation Negative Regulation Of Cardiac Muscle Hypertrophy Dopamine Transport Negative Regulation Of Muscle Hypertrophy Aggresome Assembly Regulation Of Mitochondrial Fission Neurotransmitter Uptake Norepinephrine Metabolic Process Negative Regulation Of Actin Filament Bundle Assembly Synaptic Transmission, Dopaminergic Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Zinc Ion Homeostasis Negative Regulation Of Release Of Cytochrome C From Mitochondria Response To Manganese Ion Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Ammonium Ion Cellular Response To Superoxide Regulation Of Dopamine Secretion Response To Oxidative Stress Cellular Response To Toxic Substance Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Monoamine Transport Mitochondrial Fission Cellular Response To Catecholamine Stimulus Negative Regulation Of Oxidative Stress-induced Cell Death Response To Superoxide Startle Response
Tagcloud ?		2a ablation able autophosphorylation back calmodulin camkii confined developmentally facilitation hippocampal hippocampus implication ltp mam methylazoxymethanol phosphatases plasticity postsynaptic potentiation preincubation presynaptic rats restore slices subserves synapses synaptic unchanged
Tagcloud (Difference) ?		2a ablation able autophosphorylation back calmodulin camkii confined developmentally facilitation hippocampal hippocampus implication ltp mam methylazoxymethanol phosphatases plasticity postsynaptic potentiation preincubation presynaptic rats restore slices subserves synapses synaptic unchanged
Tagcloud (Intersection) ?