HDGF and XBP1

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		HDGF	XBP1
Gene Name		hepatoma-derived growth factor	X-box binding protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Transcriptional Repressor Complex	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Nucleotide Binding RNA Polymerase II Transcription Corepressor Activity Transcription Corepressor Binding DNA Binding Growth Factor Activity Heparin Binding Poly(A) RNA Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding RNA Polymerase II Transcription Factor Binding Enhancer Sequence-specific DNA Binding Protease Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Kinase Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Signal Transduction Cell Proliferation Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Liver Development Positive Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Positive Regulation Of Immunoglobulin Production Transcription From RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process Immune Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Positive Regulation Of Autophagy Negative Regulation Of Myotube Differentiation Phosphatidylinositol 3-kinase Signaling Cell Growth Endoplasmic Reticulum Unfolded Protein Response Exocrine Pancreas Development Positive Regulation Of Histone Methylation Regulation Of Protein Stability Protein Destabilization Cellular Response To Nutrient Positive Regulation Of TOR Signaling Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress Cellular Triglyceride Homeostasis Cellular Response To Vascular Endothelial Growth Factor Stimulus Cellular Response To Glucose Starvation Response To Drug Cholesterol Homeostasis Positive Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Development Positive Regulation Of Immunoglobulin Secretion Response To Electrical Stimulus Fatty Acid Homeostasis Sterol Homeostasis Serotonin Secretion, Neurotransmission Adipose Tissue Development Epithelial Cell Maturation Involved In Salivary Gland Development Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Antibiotic Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-4 Cellular Response To Peptide Hormone Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Plasma Cell Differentiation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Acetylation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lactation Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Interleukin-6 Secretion
Pathways		IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS			Esophageal cancer (squamous cell) ( 22960999)
Protein-Protein Interactions		3 interactors: JUN SMAD4 XBP1	19 interactors: ATF6 ATF6B CREBZF ESR1 FOS FUBP3 GLI1 H1F0 H1FX HDGF NR0B2 PCBD2 RBL2 SRSF1 SSX4 TRIP4 UBE2I ZNF440 ZNF580
Entrez ID		3068	7494
HPRD ID		02079	01908
Ensembl ID		ENSG00000143321	ENSG00000100219
Uniprot IDs		P51858	P17861
PDB IDs		1RI0 2NLU
Enriched GO Terms of Interacting Partners?		Gland Development Epithelial Cell Differentiation Cellular Response To Growth Factor Stimulus SMAD Protein Signal Transduction Response To Growth Factor Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Cell Differentiation Cardiovascular System Development Transcription From RNA Polymerase II Promoter Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Neuron Development Negative Regulation Of Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Formation Involved In Morphogenesis Regulation Of Protein Phosphorylation Epithelium Development Response To Abiotic Stimulus Cellular Response To Starvation Negative Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Neuron Differentiation Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Lactation Positive Regulation Of Plasma Cell Differentiation Epithelial Cell Maturation Involved In Salivary Gland Development Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Cellular Response To Potassium Ion Starvation Serotonin Secretion, Neurotransmission Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Epithelial Cell Proliferation Liver Development Positive Regulation Of Intracellular Protein Transport Response To Endoplasmic Reticulum Stress Regulation Of Protein Import Into Nucleus Regulation Of Organ Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Nutrient Levels Regulation Of Phosphorylation Response To Starvation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Response To Transforming Growth Factor Beta Negative Regulation Of Biosynthetic Process Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Biosynthetic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Positive Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Estrogen Receptor Signaling Pathway Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Regulation Of Cellular Process Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of SUMO Transferase Activity Positive Regulation Of Nuclease Activity Regulation Of DNA-templated Transcription In Response To Stress Intracellular Steroid Hormone Receptor Signaling Pathway Chromatin Organization Cellular Response To Organic Substance Notochord Regression
Tagcloud ?		annealing apparently bm classifier clinicopathological cohort cohorts complementary deoxyribonucleic discovery distant extension hr immediate interventional ligation likelihood location neu optimize predictive qrt rad51 refined symptomatic tpr trastuzumab validation visceral	alter apc apoptotic bcl2 challenged chop contributing cytoprotective decreasing dr5 enterohemorrhagic fold hemolytic hsp40 kidneys later producing ribotoxic rodentium saline shiga spliced stx stx2 toxigenic toxins transcripts untreated uremic
Tagcloud (Difference) ?		annealing apparently bm classifier clinicopathological cohort cohorts complementary deoxyribonucleic discovery distant extension hr immediate interventional ligation likelihood location neu optimize predictive qrt rad51 refined symptomatic tpr trastuzumab validation visceral	alter apc apoptotic bcl2 challenged chop contributing cytoprotective decreasing dr5 enterohemorrhagic fold hemolytic hsp40 kidneys later producing ribotoxic rodentium saline shiga spliced stx stx2 toxigenic toxins transcripts untreated uremic
Tagcloud (Intersection) ?