LGMN and LAMC3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		LGMN	LAMC3
Gene Name		legumain	laminin, gamma 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Late Endosome Lysosomal Lumen Apical Part Of Cell Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Peptidase Activity	Structural Molecule Activity
	Biological Process	Toll-like Receptor Signaling Pathway Renal System Process Proteolysis Steroid Metabolic Process Response To Acidic PH Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Catabolic Process Negative Regulation Of Multicellular Organism Growth Vitamin D Metabolic Process Negative Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of ERBB Signaling Pathway	Cell Morphogenesis Involved In Differentiation Cell Adhesion Visual Perception Astrocyte Development Extracellular Matrix Organization Retina Development In Camera-type Eye
Pathways		Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Metabolism of lipids and lipoproteins MHC class II antigen presentation Metabolism of steroid hormones and vitamin D Vitamin D (calciferol) metabolism Adaptive Immune System Innate Immune System	Laminin interactions Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: LAMC3 USP17L2	20 interactors: ANXA5 CFB CRP CSNK2A2 CWC25 CYP2E1 EPB41L4B FRAT1 HP KIF1C LGMN NR1H2 PELI2 POT1 RPL35 SERPINA3 SLC43A3 TF YTHDC1 ZNF160
Entrez ID		5641	10319
HPRD ID		04017	05069
Ensembl ID		ENSG00000100600	ENSG00000050555
Uniprot IDs		Q53XC6 Q86TV2 Q86TV3 Q96CY7 Q99538	Q8N2D6 Q9Y6N6
PDB IDs		4AW9 4AWA 4AWB 4FGU
Enriched GO Terms of Interacting Partners?		CAAX-box Protein Processing Negative Regulation Of Histone Deacetylation Negative Regulation Of Protein Targeting To Membrane Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway Regulation Of RIG-I Signaling Pathway Protein K48-linked Deubiquitination Protein K63-linked Deubiquitination Regulation Of Ruffle Assembly Negative Regulation Of Ras GTPase Activity Astrocyte Development Regulation Of Defense Response To Virus By Host Negative Regulation Of GTPase Activity Regulation Of Histone Deacetylation Protein Maturation Astrocyte Differentiation Regulation Of Protein Deacetylation Regulation Of Defense Response To Virus Negative Regulation Of Intracellular Protein Transport Negative Regulation Of Chromosome Organization	Acute-phase Response Acute Inflammatory Response Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Regulation Of Protein Processing Defense Response Regulation Of Immune Response Regulation Of Macrophage Derived Foam Cell Differentiation Response To Stress Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of DNA Strand Elongation Negative Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of Lipid Storage Regulation Of Innate Immune Response Positive Regulation Of Immune Response Negative Regulation Of Chromosome Organization Regulation Of High-density Lipoprotein Particle Assembly Telomere Formation Via Telomerase Negative Regulation Of Proteolysis Regulation Of Immune System Process Negative Regulation Of Protein Processing Negative Regulation Of Catalytic Activity Negative Regulation Of Pinocytosis Negative Regulation Of Hydrogen Peroxide Metabolic Process
Tagcloud ?		blastocyst blastocysts competent ct custom deficiencies developmentally dpp4 dysregulated dysregulations eif2 eif4 embryos gata2 hatched hatching hb ivv krt8 manipulations nanog p70s6k pa parthenogenetic pluripotency technologies transcriptomic trophoblast xb
Tagcloud (Difference) ?		blastocyst blastocysts competent ct custom deficiencies developmentally dpp4 dysregulated dysregulations eif2 eif4 embryos gata2 hatched hatching hb ivv krt8 manipulations nanog p70s6k pa parthenogenetic pluripotency technologies transcriptomic trophoblast xb
Tagcloud (Intersection) ?