LGMN

Gene Name		legumain
Image
Gene Ontology Annotations	Cellular Component	Lysosome Late Endosome Lysosomal Lumen Apical Part Of Cell Extracellular Vesicular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Peptidase Activity
	Biological Process	Toll-like Receptor Signaling Pathway Renal System Process Proteolysis Steroid Metabolic Process Response To Acidic PH Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Catabolic Process Negative Regulation Of Multicellular Organism Growth Vitamin D Metabolic Process Negative Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of ERBB Signaling Pathway
Pathways		Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Metabolism of lipids and lipoproteins MHC class II antigen presentation Metabolism of steroid hormones and vitamin D Vitamin D (calciferol) metabolism Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: LAMC3 USP17L2
Entrez ID		5641
HPRD ID		04017
Ensembl ID		ENSG00000100600
Uniprot IDs		Q53XC6 Q86TV2 Q86TV3 Q96CY7 Q99538
PDB IDs		4AW9 4AWA 4AWB 4FGU
Enriched GO Terms of Interacting Partners?		CAAX-box Protein Processing Negative Regulation Of Histone Deacetylation Negative Regulation Of Protein Targeting To Membrane Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway Regulation Of RIG-I Signaling Pathway Protein K48-linked Deubiquitination Protein K63-linked Deubiquitination Regulation Of Ruffle Assembly Negative Regulation Of Ras GTPase Activity Astrocyte Development Regulation Of Defense Response To Virus By Host Negative Regulation Of GTPase Activity Regulation Of Histone Deacetylation Protein Maturation Astrocyte Differentiation Regulation Of Protein Deacetylation Regulation Of Defense Response To Virus Negative Regulation Of Intracellular Protein Transport Negative Regulation Of Chromosome Organization
Tagcloud ?		blastocyst blastocysts competent ct custom deficiencies developmentally dpp4 dysregulated dysregulations eif2 eif4 embryos gata2 hatched hatching hb ivv krt8 manipulations nanog p70s6k pa parthenogenetic pluripotency technologies transcriptomic trophoblast xb