LGMN

Name	legumain
Structure
Novel Interactors	1 novel interactors: FBLN5
Interactors	6 interactors: AMPH LAMC3 MAPT SET SRPK2 USP17L2
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Late Endosome Endolysosome Lumen Lysosomal Lumen Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Tau Protein Binding Endopeptidase Activator Activity
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Renal System Process Proteolysis Vacuolar Protein Processing Memory Positive Regulation Of Cell Population Proliferation Associative Learning Response To Acidic PH Negative Regulation Of Gene Expression Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Catabolic Process Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Multicellular Organism Growth Vitamin D Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Mitotic Cell Cycle Proteolysis Involved In Protein Catabolic Process Protein Maturation Cellular Response To Calcium Ion Positive Regulation Of Monocyte Chemotaxis Dendritic Spine Organization Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of ERBB Signaling Pathway Cellular Response To Amyloid-beta Positive Regulation Of Endothelial Cell Chemotaxis
Pathways	Trafficking and processing of endosomal TLR Vitamin D (calciferol) metabolism MHC class II antigen presentation
GWAS	Blood protein levels ( 30072576 ) Change in serum metabolite levels (CMS) ( 31636271 ) Systemic juvenile idiopathic arthritis ( 27927641 )
Entrez ID	5641
HPRD ID	04017
Ensembl ID	ENSG00000100600
Uniprot IDs	Q53XC6 Q96CY7 Q99538
PDB IDs	4AW9 4AWA 4AWB 4FGU 4N6N 4N6O 5LU8 5LU9 5LUA 5LUB 7FQH 7FQI 7FQJ 7FQK 7FQL 7O50 8AE4 8AE5
GO Terms Enriched among Interactors ?	Regulation Of Superoxide Metabolic Process Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Intramembranous Bone Growth