LGMN and AMPH

Number of citations: 59 (PubMedID 34018922)
Data Source: BioGRID (enzymatic study)

		LGMN	AMPH
Name		legumain	amphiphysin
Structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Late Endosome Endolysosome Lumen Lysosomal Lumen Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Actin Cytoskeleton Membrane Synaptic Vesicle Membrane Leading Edge Membrane Cytoplasmic Vesicle Synapse
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Tau Protein Binding Endopeptidase Activator Activity	Protein Binding Phospholipid Binding
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Renal System Process Proteolysis Vacuolar Protein Processing Memory Positive Regulation Of Cell Population Proliferation Associative Learning Response To Acidic PH Negative Regulation Of Gene Expression Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Catabolic Process Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Multicellular Organism Growth Vitamin D Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Mitotic Cell Cycle Proteolysis Involved In Protein Catabolic Process Protein Maturation Cellular Response To Calcium Ion Positive Regulation Of Monocyte Chemotaxis Dendritic Spine Organization Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of ERBB Signaling Pathway Cellular Response To Amyloid-beta Positive Regulation Of Endothelial Cell Chemotaxis	Endocytosis Chemical Synaptic Transmission Synaptic Vesicle Endocytosis
Pathways		Trafficking and processing of endosomal TLR Vitamin D (calciferol) metabolism MHC class II antigen presentation	Clathrin-mediated endocytosis
GWAS		Blood protein levels ( 30072576 ) Change in serum metabolite levels (CMS) ( 31636271 ) Systemic juvenile idiopathic arthritis ( 27927641 )	Ankylosing spondylitis ( 30946743 ) Bitter non-alcoholic beverage consumption ( 31046077 ) Cerebral microbleeds ( 31209788 ) Post bronchodilator FEV1 ( 26634245 )
Interacting Genes		6 interacting genes: AMPH LAMC3 MAPT SET SRPK2 USP17L2	29 interacting genes: AP2A2 ARL16 BIN1 CABIN1 CDK1 CDK5 CDK5R1 CLTC DEUP1 DNM1 DNM2 DYRK1A EGFR ITSN2 KHDRBS1 LGMN MAPK6 MAPT NECAP1 PLD2 PPP3CA PPP3CC SH3GL2 SH3GLB1 SYN1 SYNJ1 TERF1 UBC VTN
Entrez ID		5641	273
HPRD ID		04017	02687
Ensembl ID		ENSG00000100600	ENSG00000078053
Uniprot IDs		Q53XC6 Q96CY7 Q99538	P49418
PDB IDs		4AW9 4AWA 4AWB 4FGU 4N6N 4N6O 5LU8 5LU9 5LUA 5LUB 7FQH 7FQI 7FQJ 7FQK 7FQL 7O50 8AE4 8AE5	1KY7 1UTC 3SOG 4ATM 5M5S 5M61
GO Terms Enriched among Interactors		Regulation Of Superoxide Metabolic Process Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Intramembranous Bone Growth	Presynaptic Endocytosis Vesicle-mediated Transport In Synapse Presynapse Synaptic Vesicle Endocytosis Endocytosis Import Into Cell Vesicle-mediated Transport Regulation Of Cellular Component Organization Clathrin-coated Pit Receptor-mediated Endocytosis Establishment Of Localization In Cell Tau Protein Binding Vesicle Scission Regulation Of Vesicle-mediated Transport Receptor Catabolic Process Clathrin-coated Endocytic Vesicle Membrane Receptor Internalization Negative Regulation Of Macromolecule Metabolic Process Protein Kinase 5 Complex Protein Polymerization Protein Kinase Binding Positive Regulation Of Cellular Component Organization Cytosol Regulation Of Developmental Growth Negative Regulation Of Metabolic Process Identical Protein Binding Clathrin-dependent Endocytosis Positive Regulation Of Organelle Organization Positive Regulation Of Protein-containing Complex Assembly Microtubule Negative Regulation Of ERBB Signaling Pathway Clathrin Coat Disassembly Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Calmodulin-dependent Protein Phosphatase Activity Synaptic Vesicle Transport Negative Regulation Of Calcium Ion Transmembrane Transport Vesicle Uncoating Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Regulation Of DNA Replication Axon Regulation Of Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Vesicle Localization Clathrin Coat Of Coated Pit Regulation Of Growth Membrane Fission Cell Projection Organization Cytoplasmic Vesicle