LGMN and USP17L2

Number of citations of the paper that reports this interaction (PMID 24610907)
0

Data Source:
BioGRID (enzymatic study, biochemical, affinity chromatography technology)

		LGMN	USP17L2
Gene Name		legumain	ubiquitin specific peptidase 17-like family member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Late Endosome Lysosomal Lumen Apical Part Of Cell Extracellular Vesicular Exosome	Nucleus Endoplasmic Reticulum Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Peptidase Activity	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway Renal System Process Proteolysis Steroid Metabolic Process Response To Acidic PH Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Catabolic Process Negative Regulation Of Multicellular Organism Growth Vitamin D Metabolic Process Negative Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of ERBB Signaling Pathway	Cell Cycle Checkpoint Apoptotic Process Mitotic Cell Cycle Checkpoint Negative Regulation Of Protein Processing Protein Deubiquitination Regulation Of Cell Migration Negative Regulation Of Histone Deacetylation Positive Regulation Of Rho GTPase Activity Negative Regulation Of Ras GTPase Activity Regulation Of Cell Proliferation Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination CAAX-box Protein Processing Negative Regulation Of Protein Targeting To Membrane Regulation Of Ruffle Assembly Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway
Pathways		Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Metabolism of lipids and lipoproteins MHC class II antigen presentation Metabolism of steroid hormones and vitamin D Vitamin D (calciferol) metabolism Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: LAMC3 USP17L2	2 interactors: LGMN UBC
Entrez ID		5641	377630
HPRD ID		04017	16844
Ensembl ID		ENSG00000100600	ENSG00000223443
Uniprot IDs		Q53XC6 Q86TV2 Q86TV3 Q96CY7 Q99538	Q6R6M4
PDB IDs		4AW9 4AWA 4AWB 4FGU
Enriched GO Terms of Interacting Partners?		CAAX-box Protein Processing Negative Regulation Of Histone Deacetylation Negative Regulation Of Protein Targeting To Membrane Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway Regulation Of RIG-I Signaling Pathway Protein K48-linked Deubiquitination Protein K63-linked Deubiquitination Regulation Of Ruffle Assembly Negative Regulation Of Ras GTPase Activity Astrocyte Development Regulation Of Defense Response To Virus By Host Negative Regulation Of GTPase Activity Regulation Of Histone Deacetylation Protein Maturation Astrocyte Differentiation Regulation Of Protein Deacetylation Regulation Of Defense Response To Virus Negative Regulation Of Intracellular Protein Transport Negative Regulation Of Chromosome Organization	Negative Regulation Of ERBB Signaling Pathway Regulation Of ERBB Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Antigen Processing And Presentation Of Peptide Antigen Regulation Of Innate Immune Response Antigen Processing And Presentation Immune Response-regulating Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Positive Regulation Of Immune Response Viral Protein Processing Vitamin D Metabolic Process Innate Immune Response Cellular Macromolecule Catabolic Process Response To Acidic PH Regulation Of Immune Response Positive Regulation Of Immune System Process Receptor Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Cell Death Notch Receptor Processing Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Glycogen Biosynthetic Process Intracellular Transport Of Virus Negative Regulation Of Signaling Response To PH Immune Response Regulation Of Immune System Process Defense Response Cellular Polysaccharide Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Polysaccharide Biosynthetic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Apoptotic Process Proteolysis Regulation Of Cell Death Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Toll-like Receptor 5 Signaling Pathway
Tagcloud ?		blastocyst blastocysts competent ct custom deficiencies developmentally dpp4 dysregulated dysregulations eif2 eif4 embryos gata2 hatched hatching hb ivv krt8 manipulations nanog p70s6k pa parthenogenetic pluripotency technologies transcriptomic trophoblast xb
Tagcloud (Difference) ?		blastocyst blastocysts competent ct custom deficiencies developmentally dpp4 dysregulated dysregulations eif2 eif4 embryos gata2 hatched hatching hb ivv krt8 manipulations nanog p70s6k pa parthenogenetic pluripotency technologies transcriptomic trophoblast xb
Tagcloud (Intersection) ?