PRPS2 and PRPS1

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (two hybrid, biochemical)

		PRPS2	PRPS1
Gene Name		phosphoribosyl pyrophosphate synthetase 2	phosphoribosyl pyrophosphate synthetase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ribose Phosphate Diphosphokinase Complex Extracellular Vesicular Exosome	Cytosol
	Molecular Function	Magnesium Ion Binding Ribose Phosphate Diphosphokinase Activity ATP Binding AMP Binding Kinase Activity GDP Binding Carbohydrate Binding Protein Homodimerization Activity ADP Binding	Magnesium Ion Binding Ribose Phosphate Diphosphokinase Activity ATP Binding Kinase Activity Protein Homodimerization Activity
	Biological Process	5-phosphoribose 1-diphosphate Biosynthetic Process Nucleobase-containing Compound Metabolic Process AMP Biosynthetic Process Phosphorylation Organ Regeneration	Carbohydrate Metabolic Process 5-phosphoribose 1-diphosphate Biosynthetic Process Purine Nucleobase Metabolic Process Purine Nucleotide Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nervous System Development Ribonucleoside Monophosphate Biosynthetic Process Pathogenesis Phosphorylation Urate Biosynthetic Process Small Molecule Metabolic Process Hypoxanthine Biosynthetic Process
Pathways		5-Phosphoribose 1-diphosphate biosynthesis Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates	5-Phosphoribose 1-diphosphate biosynthesis Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: NOTCH2NL PRPS1 PRPSAP1 WDYHV1	5 interactors: GORASP2 PRPS2 PRPSAP1 SPG21 SUMO4
Entrez ID		5634	5631
HPRD ID		02414	02413
Ensembl ID		ENSG00000101911	ENSG00000147224
Uniprot IDs		P11908	B7ZB02 P60891
PDB IDs			2H06 2H07 2H08 2HCR 3EFH 3S5J 4F8E
Enriched GO Terms of Interacting Partners?		Urate Biosynthetic Process 5-phosphoribose 1-diphosphate Biosynthetic Process Hypoxanthine Metabolic Process Hypoxanthine Biosynthetic Process Nucleotide Biosynthetic Process Urate Metabolic Process Purine Nucleobase Biosynthetic Process Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Purine Nucleobase Metabolic Process	5-phosphoribose 1-diphosphate Biosynthetic Process AMP Biosynthetic Process Nucleotide Biosynthetic Process
Tagcloud ?		00e 19e 40e 47e asian autosomes cohorts contributors erythematosus gwas han intriguing irak1 l1cam mecp2 naa10 predisposition predominance prototype prototypic replicated replicating rs1059702 rs17422 rs2071128 rs7062536 sle tmem187 xp22
Tagcloud (Difference) ?		00e 19e 40e 47e asian autosomes cohorts contributors erythematosus gwas han intriguing irak1 l1cam mecp2 naa10 predisposition predominance prototype prototypic replicated replicating rs1059702 rs17422 rs2071128 rs7062536 sle tmem187 xp22
Tagcloud (Intersection) ?