PRPS1 and PRPS2

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (two hybrid, biochemical)

		PRPS1	PRPS2
Gene Name		phosphoribosyl pyrophosphate synthetase 1	phosphoribosyl pyrophosphate synthetase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Ribose Phosphate Diphosphokinase Complex Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Ribose Phosphate Diphosphokinase Activity ATP Binding Kinase Activity Protein Homodimerization Activity	Magnesium Ion Binding Ribose Phosphate Diphosphokinase Activity ATP Binding AMP Binding Kinase Activity GDP Binding Carbohydrate Binding Protein Homodimerization Activity ADP Binding
	Biological Process	Carbohydrate Metabolic Process 5-phosphoribose 1-diphosphate Biosynthetic Process Purine Nucleobase Metabolic Process Purine Nucleotide Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nervous System Development Ribonucleoside Monophosphate Biosynthetic Process Pathogenesis Phosphorylation Urate Biosynthetic Process Small Molecule Metabolic Process Hypoxanthine Biosynthetic Process	5-phosphoribose 1-diphosphate Biosynthetic Process Nucleobase-containing Compound Metabolic Process AMP Biosynthetic Process Phosphorylation Organ Regeneration
Pathways		5-Phosphoribose 1-diphosphate biosynthesis Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates	5-Phosphoribose 1-diphosphate biosynthesis Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: GORASP2 PRPS2 PRPSAP1 SPG21 SUMO4	4 interactors: NOTCH2NL PRPS1 PRPSAP1 WDYHV1
Entrez ID		5631	5634
HPRD ID		02413	02414
Ensembl ID		ENSG00000147224	ENSG00000101911
Uniprot IDs		B7ZB02 P60891	P11908
PDB IDs		2H06 2H07 2H08 2HCR 3EFH 3S5J 4F8E
Enriched GO Terms of Interacting Partners?		5-phosphoribose 1-diphosphate Biosynthetic Process AMP Biosynthetic Process Nucleotide Biosynthetic Process	Urate Biosynthetic Process 5-phosphoribose 1-diphosphate Biosynthetic Process Hypoxanthine Metabolic Process Hypoxanthine Biosynthetic Process Nucleotide Biosynthetic Process Urate Metabolic Process Purine Nucleobase Biosynthetic Process Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Purine Nucleobase Metabolic Process
Tagcloud ?			00e 19e 40e 47e asian autosomes cohorts contributors erythematosus gwas han intriguing irak1 l1cam mecp2 naa10 predisposition predominance prototype prototypic replicated replicating rs1059702 rs17422 rs2071128 rs7062536 sle tmem187 xp22
Tagcloud (Difference) ?			00e 19e 40e 47e asian autosomes cohorts contributors erythematosus gwas han intriguing irak1 l1cam mecp2 naa10 predisposition predominance prototype prototypic replicated replicating rs1059702 rs17422 rs2071128 rs7062536 sle tmem187 xp22
Tagcloud (Intersection) ?