PRPS2 and PRPSAP1

Number of citations of the paper that reports this interaction (PMID 9366267)
0

Data Source:
HPRD (in vitro, in vivo)

		PRPS2	PRPSAP1
Gene Name		phosphoribosyl pyrophosphate synthetase 2	phosphoribosyl pyrophosphate synthetase-associated protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ribose Phosphate Diphosphokinase Complex Extracellular Vesicular Exosome	Ribose Phosphate Diphosphokinase Complex
	Molecular Function	Magnesium Ion Binding Ribose Phosphate Diphosphokinase Activity ATP Binding AMP Binding Kinase Activity GDP Binding Carbohydrate Binding Protein Homodimerization Activity ADP Binding	Magnesium Ion Binding Ribose Phosphate Diphosphokinase Activity Enzyme Inhibitor Activity Kinase Binding
	Biological Process	5-phosphoribose 1-diphosphate Biosynthetic Process Nucleobase-containing Compound Metabolic Process AMP Biosynthetic Process Phosphorylation Organ Regeneration	Nucleobase-containing Compound Metabolic Process Nucleotide Biosynthetic Process Negative Regulation Of Kinase Activity
Pathways		5-Phosphoribose 1-diphosphate biosynthesis Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates
Drugs
Diseases
GWAS			Urate levels ( 23263486)
Protein-Protein Interactions		4 interactors: NOTCH2NL PRPS1 PRPSAP1 WDYHV1	5 interactors: DDX19B MAPK1 PLEKHF2 PRPS1 PRPS2
Entrez ID		5634	5635
HPRD ID		02414	03151
Ensembl ID		ENSG00000101911	ENSG00000161542
Uniprot IDs		P11908	Q14558
PDB IDs			2C4K
Enriched GO Terms of Interacting Partners?		Urate Biosynthetic Process 5-phosphoribose 1-diphosphate Biosynthetic Process Hypoxanthine Metabolic Process Hypoxanthine Biosynthetic Process Nucleotide Biosynthetic Process Urate Metabolic Process Purine Nucleobase Biosynthetic Process Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Purine Nucleobase Metabolic Process	5-phosphoribose 1-diphosphate Biosynthetic Process Ribonucleoside Monophosphate Biosynthetic Process Nucleoside Monophosphate Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process MAPK Import Into Nucleus Urate Biosynthetic Process Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Regulation Of Golgi Inheritance Hypoxanthine Metabolic Process Hypoxanthine Biosynthetic Process Caveolin-mediated Endocytosis Cytosine Metabolic Process AMP Biosynthetic Process Nucleocytoplasmic Transport Nuclear Transport Regulation Of Golgi Organization Nucleotide Biosynthetic Process Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Protein Transport Establishment Of Protein Localization Urate Metabolic Process Regulation Of Early Endosome To Late Endosome Transport Purine Nucleobase Biosynthetic Process AMP Metabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation ERK1 And ERK2 Cascade Phosphorylation Protein Localization JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Mammary Gland Epithelial Cell Proliferation Growth Hormone Receptor Signaling Pathway Nucleotide Metabolic Process Cellular Response To Growth Hormone Stimulus Labyrinthine Layer Blood Vessel Development Response To Epidermal Growth Factor Regulation Of Cellular Response To Heat Pyrimidine Nucleobase Metabolic Process Cytoplasmic Transport Placenta Blood Vessel Development Small Molecule Metabolic Process Lipopolysaccharide-mediated Signaling Pathway B Cell Receptor Signaling Pathway Response To Growth Hormone Purine Nucleobase Metabolic Process
Tagcloud ?		00e 19e 40e 47e asian autosomes cohorts contributors erythematosus gwas han intriguing irak1 l1cam mecp2 naa10 predisposition predominance prototype prototypic replicated replicating rs1059702 rs17422 rs2071128 rs7062536 sle tmem187 xp22
Tagcloud (Difference) ?		00e 19e 40e 47e asian autosomes cohorts contributors erythematosus gwas han intriguing irak1 l1cam mecp2 naa10 predisposition predominance prototype prototypic replicated replicating rs1059702 rs17422 rs2071128 rs7062536 sle tmem187 xp22
Tagcloud (Intersection) ?