RPSA and KARS1

Number of citations: 0 (PubMedID 22751010)
Data Source: BioGRID (two hybrid, affinity chromatography technology)

		RPSA	KARS1
Name		ribosomal protein SA	lysyl-tRNA synthetase 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Ribosome Plasma Membrane Small Ribosomal Subunit Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Extracellular Exosome Ribonucleoprotein Complex	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex
	Molecular Function	Virus Receptor Activity DNA Binding RNA Binding Structural Constituent Of Ribosome Laminin Receptor Activity Protein Binding Ribosome Binding Laminin Binding	TRNA Binding Nucleotide Binding Nucleic Acid Binding ATP:ADP Adenylyltransferase Activity Aminoacyl-tRNA Ligase Activity Lysine-tRNA Ligase Activity Protein Binding ATP Binding Amino Acid Binding Transferase Activity Ligase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Ribosomal Small Subunit Assembly Cytoplasmic Translation Chromatin Remodeling Translation Cell Adhesion Symbiont Entry Into Host Cell Antiviral Innate Immune Response	Basophil Activation Involved In Immune Response Positive Regulation Of Inflammatory Response To Antigenic Stimulus Translation TRNA Aminoacylation For Protein Translation Lysyl-tRNA Aminoacylation TRNA Processing Response To X-ray Diadenosine Tetraphosphate Biosynthetic Process Positive Regulation Of Macrophage Activation Positive Regulation Of DNA-templated Transcription ERK1 And ERK2 Cascade
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Tigapotide Copper	Lysine
Diseases		None	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Dentate gyrus volume x schizophrenia interaction ( 31155012 )	No GWAS studies recorded
Interacting Genes		37 interacting genes: ABCD1 ACADVL ACD ANKH CALM2 CBX5 CCDC13 CLEC4G CSF2RA DCTN6 EIF3E FILNC1 GNMT HBG2 HNRNPD HSPB1 IL7R ILRUN ITGA6 KARS1 LAMA2 LINC01554 NKX3-1 OGT PDE4B PEA15 POT1 PRND PROS1 RNF114 RPS21 SLC2A5 SUMO4 TINF2 TRIB3 TSC2 USP2-AS1	87 interacting genes: AIMP2 CDC42 CEBPA DARS2 DYSF EEF1D EEF1G ESR1 FNDC3B FRS3 GAPDH GEMIN4 LINC01554 MAPK1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-2 MIR18B MIR199A1 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR25 MIR29A MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-3 MIR92A1 MIR92A2 MIR93 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OGT PAFAH1B1 PIK3R3 RPSA SLC25A6 SOD1 SPTAN1 SUMO2 VIM
Entrez ID		3921	3735
HPRD ID		01038	03249
Ensembl ID		ENSG00000168028	ENSG00000065427
Uniprot IDs		A0A0C4DG17 P08865	Q15046
PDB IDs		3BCH 4UG0 4V5Z 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G18 6G4S 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBD 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7QP6 7QP7 7QVP 7R4X 7TQL 7WTV 7WTW 7WTX 7WTZ 7WU0 7XNX 7XNY 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8RG0 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O	3BJU 4DPG 4YCU 4YCW 6CHD 6ILD 6ILH 7EA9 8HYR 8XP4 9DOW 9DPA 9DPB 9DPL
GO Terms Enriched among Interactors		Telomere Assembly Shelterin Complex Telomeric DNA Binding Nuclear Telomere Cap Complex Regulation Of Telomere Maintenance Via Telomerase Telomere Capping Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Translational Initiation Fructose Binding Telomerase Inhibitor Activity Negative Regulation Of Telomere Maintenance Establishment Of Protein Localization To Telomere Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Translational Initiation Negative Regulation Of Biosynthetic Process Response To Sodium Phosphate Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Insulin Receptor Signaling Pathway Chromosome, Telomeric Region Urogenital System Development Regulation Of Small Molecule Metabolic Process Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Binding Regulation Of Lipid Biosynthetic Process Negative Regulation Of Fatty Acid Biosynthetic Process Translation Telomere Maintenance Via Telomerase Negative Regulation Of Metabolic Process Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Response To Salt Regulation Of T Cell Differentiation In Thymus RNA-templated DNA Biosynthetic Process Telomere Maintenance Very Long-chain Fatty-acyl-CoA Catabolic Process Negative Regulation Of Macromolecule Metabolic Process ABC-type Fatty-acyl-CoA Transporter Activity Hepatocyte Dedifferentiation Regulation Of Translation Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Cellular Response To Putrescine	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Biosynthetic Process Extracellular Vesicle Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Translation Negative Regulation Of Cell Migration MRNA Destabilization Negative Regulation Of Cell Motility RNA Destabilization Negative Regulation Of Locomotion Positive Regulation Of MRNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of Translation Negative Regulation Of Cytokine Production Regulation Of Macromolecule Metabolic Process Regulation Of RNA Stability Regulation Of Cell Migration Regulation Of Angiogenesis Negative Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Vasculature Development Regulation Of Cell Motility Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Locomotion Negative Regulation Of Developmental Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Regulation Of Metabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of MRNA Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway