NXF3 and SKIL

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		NXF3	SKIL
Description		nuclear RNA export factor 3	SKI like proto-oncogene
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear RNA Export Factor Complex	Acrosomal Vesicle Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm PML Body Protein-containing Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein-containing Complex Binding SMAD Binding
	Biological Process	MRNA Export From Nucleus Poly(A)+ MRNA Export From Nucleus MRNA Transport	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Formation Lymphocyte Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Spermatogenesis Skeletal Muscle Tissue Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Response To Cytokine Negative Regulation Of Cell Differentiation Response To Antibiotic Regulation Of Neurogenesis Positive Regulation Of Axonogenesis Regulation Of Cell Cycle Muscle Structure Development Lens Fiber Cell Differentiation Response To Growth Factor Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways			Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity
Drugs
Diseases
GWAS		Educational attainment (years of education) ( 30038396)	Aspartate aminotransferase levels ( 33547301) Estimated glomerular filtration rate ( 31152163) Glomerular filtration rate (creatinine) ( 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Prostate cancer ( 21743467)
Interacting Genes		7 interacting genes: EIF4ENIF1 HNRNPUL1 NXF1 NXT1 NXT2 SKIL XPO1	97 interacting genes: ASCC3 CAMSAP1 CBX4 CDC16 CDC27 CHD3 CHPF COL4A2 CPNE1 CPNE2 CPNE4 CXXC5 DEUP1 DHX30 DRC4 DRG1 DSCAM EEF1G EIF4G2 ESR1 FAF1 FBLN1 FN1 FZR1 GLUL GOLGB1 HEY1 HEYL HIPK1 HIPK3 HNRNPLL IL36RN KRT81 LRP1 MACF1 MORC4 MVP MYG1 NCOR1 NCOR2 NEFL NID1 NID2 NXF3 OIP5 PAPPA PIAS1 PIAS3 PIAS4 PLCD3 PPL PSG3 PSMC2 PTPRF PYCR2 RNF4 RPS27 SASH1 SETDB1 SKI SMAD1 SMAD2 SMAD3 SMAD4 SMUG1 SMURF2 SNRNP70 SNX17 SPARCL1 SRP72 STK16 SVEP1 TDG TDP2 TFPI2 THAP5 THSD7A TLE5 TPM2 TRAK1 TRIM62 TRIM69 TSKU TTF2 UBE2I UIMC1 USP25 VPS28 XPA XRCC6 ZBTB3 ZBTB6 ZMYM2 ZMYM5 ZNF106 ZNF200 ZZEF1
Entrez ID		56000	6498
HPRD ID		02261	01319
Ensembl ID		ENSG00000147206	ENSG00000136603
Uniprot IDs		Q9H4D5	P12757
PDB IDs			3EQ5 5C4V
Enriched GO Terms of Interacting Partners?		Nuclear Export Nuclear RNA Export Factor Complex MRNA Export From Nucleus Nuclear Transport Nucleocytoplasmic Transport RNA Export From Nucleus Poly(A)+ MRNA Export From Nucleus MRNA Transport RNA Transport Nucleobase-containing Compound Transport Nuclear Pore Central Transport Channel Nuclear Export Signal Receptor Activity Protein Transport Intracellular Transport Establishment Of Protein Localization Protein Export From Nucleus Cellular Localization Establishment Of Localization In Cell Intracellular Protein Localization Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Nuclear Speck Nuclear Pore Nucleoplasm PML Body Cellular Response To Triglyceride Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Nucleus Intracellular Protein Transport Response To Triglyceride RNA Binding Annulate Lamellae Protein Localization To Nucleus Cellular Response To Salt Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Nuclear Envelope Protein Domain Specific Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Ribosomal Subunit Export From Nucleus MRNA Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Nuclear Inclusion Body Transcription Export Complex Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Small GTPase Binding Lens Fiber Cell Differentiation P-body Assembly	PML Body Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process SMAD Protein Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleus Heteromeric SMAD Protein Complex SUMO Transferase Activity Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process SUMO Ligase Activity I-SMAD Binding Collagen Binding Regulation Of Macromolecule Metabolic Process Response To Transforming Growth Factor Beta Regulation Of MiRNA Transcription Protein Metabolic Process Metal Ion Binding Protein Modification By Small Protein Conjugation Nuclear Body Cell Surface Receptor Signaling Pathway Regulation Of Primary Metabolic Process SMAD Protein Signal Transduction Protein Sumoylation Regulation Of MiRNA Metabolic Process Negative Regulation Of MiRNA Transcription Zinc Ion Binding Regulation Of Metabolic Process Cytoplasm Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus SUMO Binding Homomeric SMAD Protein Complex Negative Regulation Of Transforming Growth Factor Beta Production Co-SMAD Binding Regulation Of Gene Expression Regulation Of Developmental Process Extracellular Matrix Structural Constituent Primary MiRNA Processing Positive Regulation Of Protein Sumoylation Regulation Of Protein Catabolic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cytosol
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