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MAPK1 and PPP2CA
Number of citations of the paper that reports this interaction (PubMedID
12624094
)
0
Data Source:
HPRD
(in vitro)
MAPK1
PPP2CA
Description
mitogen-activated protein kinase 1
protein phosphatase 2 catalytic subunit alpha
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Early Endosome
Late Endosome
Endoplasmic Reticulum Lumen
Golgi Apparatus
Centrosome
Spindle
Cytosol
Cytoskeleton
Plasma Membrane
Caveola
Focal Adhesion
Cilium
Microtubule Cytoskeleton
Membrane
Pseudopodium
Azurophil Granule Lumen
Ciliary Basal Body
Synapse
Anchoring Junction
Mitotic Spindle
Ficolin-1-rich Granule Lumen
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Chromatin
Spindle Pole
Nucleus
Chromosome
Cytoplasm
Mitochondrion
Cytosol
Cytoskeleton
Plasma Membrane
Protein Serine/threonine Phosphatase Complex
Microtubule Cytoskeleton
Membrane
Membrane Raft
Synapse
Extracellular Exosome
FAR/SIN/STRIPAK Complex
INTAC Complex
Molecular Function
Nucleotide Binding
Phosphotyrosine Residue Binding
DNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Kinase Activity
Transferase Activity
Phosphatase Binding
Identical Protein Binding
Protein Serine Kinase Activity
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Hydrolase Activity
Metal Ion Binding
Protein Heterodimerization Activity
Tau Protein Binding
GABA Receptor Binding
RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity
RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity
RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity
Biological Process
MAPK Cascade
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Apoptotic Process
Chemotaxis
DNA Damage Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Chemical Synaptic Transmission
Heart Development
Learning Or Memory
Insulin Receptor Signaling Pathway
Animal Organ Morphogenesis
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Peptidyl-threonine Phosphorylation
Neural Crest Cell Development
Schwann Cell Development
Peptidyl-threonine Phosphorylation
Cytosine Metabolic Process
Regulation Of Ossification
Regulation Of Cellular PH
Thyroid Gland Development
Regulation Of Protein Stability
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Telomere Maintenance
Response To Lipopolysaccharide
Regulation Of Stress-activated MAPK Cascade
Mammary Gland Epithelial Cell Proliferation
Cellular Response To Amino Acid Starvation
Response To Nicotine
Intracellular Signal Transduction
ERBB Signaling Pathway
ERBB2-ERBB3 Signaling Pathway
Outer Ear Morphogenesis
Myelination
Response To Exogenous DsRNA
Positive Regulation Of Cholesterol Biosynthetic Process
Negative Regulation Of Cell Differentiation
Insulin-like Growth Factor Receptor Signaling Pathway
Thymus Development
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Stress-activated MAPK Cascade
Regulation Of Cytoskeleton Organization
Bergmann Glial Cell Differentiation
Long-term Synaptic Potentiation
Face Development
Lung Morphogenesis
Trachea Formation
Labyrinthine Layer Blood Vessel Development
Cardiac Neural Crest Cell Development Involved In Heart Development
Interleukin-34-mediated Signaling Pathway
Chemokine-mediated Signaling Pathway
ERK1 And ERK2 Cascade
Response To Epidermal Growth Factor
Cellular Response To Tumor Necrosis Factor
Caveolin-mediated Endocytosis
Regulation Of Golgi Inheritance
Positive Regulation Of Macrophage Proliferation
Positive Regulation Of Neuroinflammatory Response
Regulation Of Early Endosome To Late Endosome Transport
Mitotic Cell Cycle
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Transcription Elongation By RNA Polymerase II
Protein Dephosphorylation
Mesoderm Development
Response To Lead Ion
Negative Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Microtubule Polymerization
Negative Regulation Of Hippo Signaling
Intracellular Signal Transduction
Peptidyl-threonine Dephosphorylation
Regulation Of Growth
T Cell Homeostasis
Regulation Of Cell Differentiation
Meiotic Cell Cycle
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Canonical Wnt Signaling Pathway
Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress
RNA Polymerase II Transcription Initiation Surveillance
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
phospho-PLA2 pathway
RAF-independent MAPK1/3 activation
MAPK1 (ERK2) activation
Signaling by NODAL
Spry regulation of FGF signaling
Signaling by Activin
Golgi Cisternae Pericentriolar Stack Reorganization
Frs2-mediated activation
ERK/MAPK targets
ERK/MAPK targets
ERKs are inactivated
Regulation of actin dynamics for phagocytic cup formation
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
NCAM signaling for neurite out-growth
Recycling pathway of L1
RSK activation
Signal transduction by L1
Activation of the AP-1 family of transcription factors
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate NADPH Oxidases
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signal attenuation
Interferon gamma signaling
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
ESR-mediated signaling
RUNX2 regulates osteoblast differentiation
Regulation of PTEN gene transcription
Regulation of the apoptosome activity
Estrogen-stimulated signaling through PRKCZ
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Suppression of apoptosis
Signaling downstream of RAS mutants
Signaling by MAP2K mutants
Signaling by MAPK mutants
Signaling by RAF1 mutants
FCGR3A-mediated phagocytosis
Nuclear events stimulated by ALK signaling in cancer
IFNG signaling activates MAPKs
Negative Regulation of CDH1 Gene Transcription
NPAS4 regulates expression of target genes
NPAS4 regulates expression of target genes
Growth hormone receptor signaling
Signaling by LTK in cancer
Transcriptional and post-translational regulation of MITF-M expression and activity
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Initiation of Nuclear Envelope (NE) Reformation
Co-stimulation by CD28
Co-inhibition by CTLA4
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
PKR-mediated signaling
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Acetylsalicylic acid
Minocycline
Arsenic trioxide
Olomoucine
Phosphonothreonine
Colforsin
Purvalanol
SB220025
Seliciclib
Perifosine
N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE
(S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
(3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE
5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE
Hypothemycin
[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
4-[4-(4-Fluorophenyl)-2-[4-[(R)-methylsulfinyl]phenyl]-1H-imidazol-5-yl]pyridine
Turpentine
Ulixertinib
Vitamin E
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS
Bipolar disorder (
31043756
)
Body size at age 10 (
32376654
)
Inflammatory bowel disease (
23128233
)
Multiple sclerosis (
21833088
24076602
31604244
)
Serum interleukin-6 concentration in active individuals (
32928877
)
Superior parietal cortex volume (
31530798
)
Interacting Genes
255 interacting genes:
AR
ARRB1
ARRB2
ATF2
ATM
ATP1A1
BANP
BCL2
BCL3
BCL6
BRAF
BTRC
C1QBP
CACYBP
CAD
CALCOCO1
CAPN2
CASP8
CASP9
CAV1
CD19
CDC25C
CDX2
CEBPA
CEBPB
CEP55
CHN1
CITED2
CMTM3
COPS6
CREBBP
CRP
CSNK2A1
CTNND1
CTSD
CUEDC2
DAPK1
DUSP1
DUSP16
DUSP2
DUSP3
DUSP4
DUSP5
DUSP6
DUSP7
DUSP9
DYRK1B
EGFR
EGLN3
EIF4EBP1
ELK1
ELK4
ENAH
EP300
EPOR
ERF
ESR1
ESR2
ETS1
FCGR2B
FHL3
FOS
FOXO3
FRS2
FRS3
GAB1
GAB2
GABRR1
GAPDH
GATA1
GATA2
GATA4
GJA1
GMFB
GNPTAB
GORASP2
GRB10
GRB2
GSK3B
HDAC4
HDAC6
HERC3
HIF1A
HMGA1
HNF4A
HOMEZ
HSF1
HSF4
HSP90AA1
ID2
IER3
IFI35
IFNAR1
ILF3
IQGAP1
IRS1
ITGB6
JUND
KARS1
KDR
KHDRBS1
KLF11
KRT8
KSR1
KSR2
LAMTOR3
LCK
LIFR
LIPE
LRPAP1
LRRC4
LZTS2
MAFA
MAP2K1
MAP2K2
MAP2K4
MAP2K6
MAP2K7
MAP3K1
MAP3K10
MAPK14
MAPK8
MAPKAPK5
MAPT
MBP
MCL1
MDFI
ME1
METAP2
METTL3
MITF
MKNK1
MKNK2
MSX2
MTIF3
MTPN
MYB
MYC
NCOA1
NCOA3
NDE1
NEFH
NEK2
NGFR
NKX2-1
NOXA1
NR3C1
NR4A1
NR4A2
NR5A1
NRL
NTRK3
NUP153
PAK1
PAK2
PAX5
PDE4D
PEA15
PEBP1
PKM
PLA2G4A
PLAGL2
PLAT
PLCB1
PLEKHM1
PLK3
POLR2G
PPARA
PPARG
PPP1CA
PPP1R18
PPP1R9B
PPP2CA
PPP2R5B
PPP2R5C
PRDX6
PRKCD
PRKCE
PRKCZ
PRPSAP1
PSMA1
PTPN1
PTPN5
PTPN7
PTPRC
PTPRE
PTPRH
PTPRR
PXN
RAF1
RB1
REST
RET
RGS19
RNF216
RNF8
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KB1
RPTOR
RUNX1
RXRA
SCNN1G
SH2D3C
SHANK3
SHC1
SLC9A1
SMAD1
SMAD2
SMAD3
SMAD4
SNCA
SNCG
SORBS3
SOS1
SOX10
SP1
SREBF1
SREBF2
STAT3
STAT5A
STAT5B
STXBP1
STYX
SUPT20H
TCF3
TFCP2
TGIF1
TH
TIAL1
TLE5
TNFRSF1A
TNFRSF25
TNFSF11
TNIP1
TNIP2
TNKS2
TOB1
TOP2A
TP53
TPR
TSC2
TTN
TXNIP
UBE3A
UBR5
UBTF
VAV1
VDR
YBX1
YBX3
ZBTB42
ZFP36
101 interacting genes:
ADCY8
AKAP6
AKT1
AKT3
AMOTL2
APC
AXIN1
BCL2
BEST1
BMPR1B
BRAF
C3orf36
CAD
CAMK1
CARD11
CAV1
CCNG1
CCNG2
CDC42BPB
CDK2
CDK6
CDKN2C
CEBPA
CHEK2
CLPP
CSNK2B
CXCR2
DELEC1
DVL3
EEF2
EIF4EBP1
ETF1
FCAR
GABRB3
GAD1
GOLGA2
HTT
IGBP1
ISYNA1
JAK2
KISS1R
L3MBTL3
MAP4K1
MAP4K3
MAP4K4
MAPK1
MAPK3
MAPT
MID1
MRPS26
MYC
MYH9
NME2
NOSIP
NXN
PACS1
PAK1
PIM1
POLR2A
PPP1CA
PPP2R1A
PPP2R1B
PPP2R2A
PPP2R3B
PPP2R5B
PPP2R5C
PPP2R5E
PRKAA1
PRKCD
PTEN
PTN
PXN
PYGM
RACGAP1
RBL2
RELA
RHO
RHOB
RORC
RPS6KB1
RRAS
SET
SGK1
SGO1
SGO2
STAT5A
STAT5B
STRN
TIAM1
TLX1
TP53
TRIM28
TRIM35
TRIP13
TSC2
UBAP2
UBC
VAC14
VDR
XRN1
YPEL3
Entrez ID
5594
5515
HPRD ID
01496
08912
Ensembl ID
ENSG00000100030
ENSG00000113575
Uniprot IDs
P28482
Q1HBJ4
Q499G7
B3KQ51
B3KUN1
P67775
PDB IDs
1PME
1TVO
1WZY
2OJG
2OJI
2OJJ
2Y9Q
3D42
3D44
3I5Z
3I60
3SA0
3TEI
3W55
4FMQ
4FUX
4FUY
4FV0
4FV1
4FV2
4FV3
4FV4
4FV5
4FV6
4FV7
4FV8
4FV9
4G6N
4G6O
4H3P
4H3Q
4IZ5
4IZ7
4IZA
4N0S
4NIF
4O6E
4QP1
4QP2
4QP3
4QP4
4QP6
4QP7
4QP8
4QP9
4QPA
4QTA
4QTE
4XJ0
4ZXT
4ZZM
4ZZN
4ZZO
5AX3
5BUE
5BUI
5BUJ
5BVD
5BVE
5BVF
5K4I
5LCJ
5LCK
5NGU
5NHF
5NHH
5NHJ
5NHL
5NHO
5NHP
5NHV
5V60
5V61
5V62
5WP1
6D5Y
6DMG
6G54
6G8X
6G91
6G92
6G93
6G97
6G9A
6G9D
6G9H
6G9J
6G9K
6G9M
6G9N
6GDM
6GDQ
6GE0
6GJB
6GJD
6NBS
6OPG
6OPH
6OPI
6Q7K
6Q7S
6Q7T
6QA1
6QA3
6QA4
6QAG
6QAH
6QAL
6QAQ
6QAW
6RQ4
6SLG
7AUV
7E73
7E75
7NQQ
7NQW
7NR3
7NR5
7NR8
7NR9
7OPM
7W5O
7X4U
7XC1
8AO2
8AO3
8AO4
8AO5
8AO6
8AO7
8AO8
8AO9
8AOA
8AOB
8AOC
8AOD
8AOE
8AOF
8AOG
8AOH
8AOI
8AOJ
8PSR
8PST
8PSW
8PSY
8PT0
8PT1
8PT3
8PT5
8PVU
8R5F
8U8J
8U8K
8ZJV
2IAE
2IE3
2IE4
2NPP
2NYL
2NYM
3C5W
3DW8
3FGA
3K7V
3K7W
3P71
4I5L
4I5N
4IYP
4LAC
4NY3
5W0W
6NTS
7CUN
7K36
7PKS
7SOY
7YCX
8RBX
8RBZ
8RC4
8SO0
8TTB
8TWE
8TWI
8U1X
8U89
8UWB
8YJB
Enriched GO Terms of Interacting Partners
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Intracellular Signal Transduction
Signal Transduction
Regulation Of Cell Communication
Regulation Of Signal Transduction
Regulation Of Signaling
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
MAPK Cascade
Regulation Of Intracellular Signal Transduction
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Intracellular Signaling Cassette
Regulation Of DNA-templated Transcription
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Cytosol
Regulation Of Multicellular Organismal Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Response To Hormone
Cytoplasm
Nucleus
Negative Regulation Of Metabolic Process
Response To Lipid
Nucleoplasm
Positive Regulation Of Multicellular Organismal Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cell Surface Receptor Signaling Pathway
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Cellular Response To Oxygen-containing Compound
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Signal Transduction
DNA-binding Transcription Factor Activity
Signal Transduction
Intracellular Signal Transduction
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Serine Kinase Activity
Cytosol
Regulation Of Cell Population Proliferation
Protein Phosphatase Regulator Activity
Protein Phosphorylation
Protein Phosphatase Type 2A Complex
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Kinase Activity
Phosphorylation
Regulation Of Protein Metabolic Process
Intracellular Signaling Cassette
Apoptotic Process
Regulation Of Cell Cycle
Programmed Cell Death
Cell Death
Protein Phosphatase 2A Binding
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Phosphate-containing Compound Metabolic Process
Regulation Of Cell Communication
Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Regulation Of Signal Transduction
Cytoplasm
Nucleus
Response To Ketone
Response To Lipid
Regulation Of Mitotic Cell Cycle
Response To Starvation
Positive Regulation Of Intracellular Signal Transduction
Protein Modification Process
Regulation Of Cell Differentiation
Positive Regulation Of Cell Population Proliferation
Identical Protein Binding
Positive Regulation Of Apoptotic Process
Cellular Response To Stress
Protein Metabolic Process
Response To Nutrient Levels
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Apoptotic Process
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cellular Component Organization
Cellular Response To Oxygen-containing Compound
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