MAPK1 and BCL6

Number of citations of the paper that reports this interaction (PubMedID 9649500)
57

Data Source:
HPRD (in vitro)

		MAPK1	BCL6
Description		mitogen-activated protein kinase 1	BCL6 transcription repressor
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Early Endosome Late Endosome Endoplasmic Reticulum Lumen Golgi Apparatus Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Caveola Focal Adhesion Cilium Microtubule Cytoskeleton Membrane Pseudopodium Azurophil Granule Lumen Ciliary Basal Body Synapse Anchoring Junction Mitotic Spindle Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Replication Fork Nucleolus Golgi Apparatus Paraspeckles
	Molecular Function	Nucleotide Binding Phosphotyrosine Residue Binding DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Kinase Activity Transferase Activity Phosphatase Binding Identical Protein Binding Protein Serine Kinase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intronic Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MAPK Cascade Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Apoptotic Process Chemotaxis DNA Damage Response Signal Transduction Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Chemical Synaptic Transmission Heart Development Learning Or Memory Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Peptidyl-threonine Phosphorylation Neural Crest Cell Development Schwann Cell Development Peptidyl-threonine Phosphorylation Cytosine Metabolic Process Regulation Of Ossification Regulation Of Cellular PH Thyroid Gland Development Regulation Of Protein Stability Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Telomere Maintenance Response To Lipopolysaccharide Regulation Of Stress-activated MAPK Cascade Mammary Gland Epithelial Cell Proliferation Cellular Response To Amino Acid Starvation Response To Nicotine Intracellular Signal Transduction ERBB Signaling Pathway ERBB2-ERBB3 Signaling Pathway Outer Ear Morphogenesis Myelination Response To Exogenous DsRNA Positive Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Cell Differentiation Insulin-like Growth Factor Receptor Signaling Pathway Thymus Development T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Stress-activated MAPK Cascade Regulation Of Cytoskeleton Organization Bergmann Glial Cell Differentiation Long-term Synaptic Potentiation Face Development Lung Morphogenesis Trachea Formation Labyrinthine Layer Blood Vessel Development Cardiac Neural Crest Cell Development Involved In Heart Development Interleukin-34-mediated Signaling Pathway Chemokine-mediated Signaling Pathway ERK1 And ERK2 Cascade Response To Epidermal Growth Factor Cellular Response To Tumor Necrosis Factor Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Positive Regulation Of Macrophage Proliferation Positive Regulation Of Neuroinflammatory Response Regulation Of Early Endosome To Late Endosome Transport	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Regulation Of Cytokine Production Negative Regulation Of Cell-matrix Adhesion Plasma Cell Differentiation Immune System Process Germinal Center Formation Regulation Of Germinal Center Formation Regulation Of Immune System Process Negative Regulation Of Type 2 Immune Response Negative Regulation Of B Cell Apoptotic Process Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response DNA Damage Response Cell-matrix Adhesion Rho Protein Signal Transduction Spermatogenesis Intracellular Protein Localization Cell Population Proliferation Pyramidal Neuron Differentiation Actin Cytoskeleton Organization B Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Heterochromatin Formation Negative Regulation Of Mast Cell Cytokine Production Mononuclear Cell Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Rho Protein Signal Transduction Type 2 Immune Response B Cell Proliferation Regulation Of Cell Population Proliferation Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Memory T Cell Differentiation T-helper 2 Cell Differentiation Regulation Of T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Isotype Switching To IgE Isotypes Negative Regulation Of Isotype Switching To IgE Isotypes Erythrocyte Development Cell Motility Regulation Of Inflammatory Response Regulation Of Immune Response Positive Regulation Of Lymphocyte Activation Negative Regulation Of Plasma Cell Differentiation Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Cell Motility Negative Regulation Of Cellular Senescence
Pathways		phospho-PLA2 pathway RAF-independent MAPK1/3 activation MAPK1 (ERK2) activation Signaling by NODAL Spry regulation of FGF signaling Signaling by Activin Golgi Cisternae Pericentriolar Stack Reorganization Frs2-mediated activation ERK/MAPK targets ERK/MAPK targets ERKs are inactivated Regulation of actin dynamics for phagocytic cup formation Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Oncogene Induced Senescence FCERI mediated MAPK activation Regulation of HSF1-mediated heat shock response NCAM signaling for neurite out-growth Recycling pathway of L1 RSK activation Signal transduction by L1 Activation of the AP-1 family of transcription factors Thrombin signalling through proteinase activated receptors (PARs) Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate NADPH Oxidases RAF/MAP kinase cascade MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signal attenuation Interferon gamma signaling Advanced glycosylation endproduct receptor signaling Gastrin-CREB signalling pathway via PKC and MAPK ESR-mediated signaling RUNX2 regulates osteoblast differentiation Regulation of PTEN gene transcription Regulation of the apoptosome activity Estrogen-stimulated signaling through PRKCZ Estrogen-dependent nuclear events downstream of ESR-membrane signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Suppression of apoptosis Signaling downstream of RAS mutants Signaling by MAP2K mutants Signaling by MAPK mutants Signaling by RAF1 mutants FCGR3A-mediated phagocytosis Nuclear events stimulated by ALK signaling in cancer IFNG signaling activates MAPKs Negative Regulation of CDH1 Gene Transcription NPAS4 regulates expression of target genes NPAS4 regulates expression of target genes Growth hormone receptor signaling Signaling by LTK in cancer Transcriptional and post-translational regulation of MITF-M expression and activity	Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain FOXO-mediated transcription of cell death genes
Drugs		Acetylsalicylic acid Minocycline Arsenic trioxide Olomoucine Phosphonothreonine Colforsin Purvalanol SB220025 Seliciclib Perifosine N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE (3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE Hypothemycin [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID 4-[4-(4-Fluorophenyl)-2-[4-[(R)-methylsulfinyl]phenyl]-1H-imidazol-5-yl]pyridine Turpentine Ulixertinib
Diseases			Hairy-cell leukemia
GWAS		Bipolar disorder ( 31043756) Body size at age 10 ( 32376654) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088 24076602 31604244) Serum interleukin-6 concentration in active individuals ( 32928877) Superior parietal cortex volume ( 31530798)	Adverse response to drug ( 30420678) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Allergic sensitization ( 23817571) Appendicular lean mass ( 33097823) Asthma ( 31959851) B cell non-Hodgkin lymphoma ( 23749188) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Blood urea nitrogen levels ( 29403010) Glucose homeostasis traits ( 25524916) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494) PR interval ( 23534349) Pulmonary function (smoking interaction) ( 23284291) Renal function-related traits (BUN) ( 22797727) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Triglyceride levels ( 32203549) Type 2 diabetes ( 25760438)
Interacting Genes		255 interacting genes: AR ARRB1 ARRB2 ATF2 ATM ATP1A1 BANP BCL2 BCL3 BCL6 BRAF BTRC C1QBP CACYBP CAD CALCOCO1 CAPN2 CASP8 CASP9 CAV1 CD19 CDC25C CDX2 CEBPA CEBPB CEP55 CHN1 CITED2 CMTM3 COPS6 CREBBP CRP CSNK2A1 CTNND1 CTSD CUEDC2 DAPK1 DUSP1 DUSP16 DUSP2 DUSP3 DUSP4 DUSP5 DUSP6 DUSP7 DUSP9 DYRK1B EGFR EGLN3 EIF4EBP1 ELK1 ELK4 ENAH EP300 EPOR ERF ESR1 ESR2 ETS1 FCGR2B FHL3 FOS FOXO3 FRS2 FRS3 GAB1 GAB2 GABRR1 GAPDH GATA1 GATA2 GATA4 GJA1 GMFB GNPTAB GORASP2 GRB10 GRB2 GSK3B HDAC4 HDAC6 HERC3 HIF1A HMGA1 HNF4A HOMEZ HSF1 HSF4 HSP90AA1 ID2 IER3 IFI35 IFNAR1 ILF3 IQGAP1 IRS1 ITGB6 JUND KARS1 KDR KHDRBS1 KLF11 KRT8 KSR1 KSR2 LAMTOR3 LCK LIFR LIPE LRPAP1 LRRC4 LZTS2 MAFA MAP2K1 MAP2K2 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K10 MAPK14 MAPK8 MAPKAPK5 MAPT MBP MCL1 MDFI ME1 METAP2 METTL3 MITF MKNK1 MKNK2 MSX2 MTIF3 MTPN MYB MYC NCOA1 NCOA3 NDE1 NEFH NEK2 NGFR NKX2-1 NOXA1 NR3C1 NR4A1 NR4A2 NR5A1 NRL NTRK3 NUP153 PAK1 PAK2 PAX5 PDE4D PEA15 PEBP1 PKM PLA2G4A PLAGL2 PLAT PLCB1 PLEKHM1 PLK3 POLR2G PPARA PPARG PPP1CA PPP1R18 PPP1R9B PPP2CA PPP2R5B PPP2R5C PRDX6 PRKCD PRKCE PRKCZ PRPSAP1 PSMA1 PTPN1 PTPN5 PTPN7 PTPRC PTPRE PTPRH PTPRR PXN RAF1 RB1 REST RET RGS19 RNF216 RNF8 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KB1 RPTOR RUNX1 RXRA SCNN1G SH2D3C SHANK3 SHC1 SLC9A1 SMAD1 SMAD2 SMAD3 SMAD4 SNCA SNCG SORBS3 SOS1 SOX10 SP1 SREBF1 SREBF2 STAT3 STAT5A STAT5B STXBP1 STYX SUPT20H TCF3 TFCP2 TGIF1 TH TIAL1 TLE5 TNFRSF1A TNFRSF25 TNFSF11 TNIP1 TNIP2 TNKS2 TOB1 TOP2A TP53 TPR TSC2 TTN TXNIP UBE3A UBR5 UBTF VAV1 VDR YBX1 YBX3 ZBTB42 ZFP36	91 interacting genes: ANKRD53 ARHGEF9 ARRDC3 ATP23 BCL11A BCL6B BCOR BLZF1 CABP4 CDK19 CDK8 CFAP161 CFAP97D1 CHD3 CNOT2 CRBN CREBBP CTNNB1 CUTC DVL2 ENO1 EP300 FBXO11 GATA1 GLRX3 GOLGA2 HDAC1 HDAC4 HDAC5 HDAC7 HDAC9 IHO1 IRF4 JUN JUNB JUND KIFC3 KLHL12 KLHL20 KRTAP13-1 KRTAP13-2 KRTAP19-1 LIMS3 LIMS4 MAPK1 MDFI MED17 MED6 MTA3 MTUS2 NCOR1 NCOR2 PAK1 PBX4 PELI1 PFDN5 PIN1 PML POF1B PPARD PPTC7 PRKD3 PSMB4 RAF1 REL RUNX1T1 SIAH1 SIN3A SNCA SP1 SPI1 SPMIP2 SPMIP4 SPMIP6 SSX2IP TEKT4 TFIP11 TLE5 TP53 TP53BP1 TRAF1 TRAF2 TRIB3 TWIST1 WDR83 WNK4 ZBTB16 ZBTB17 ZBTB7A ZBTB7B ZNHIT1
Entrez ID		5594	604
HPRD ID		01496	00180
Ensembl ID		ENSG00000100030	ENSG00000113916
Uniprot IDs		P28482 Q1HBJ4 Q499G7	B5B0A5 P41182
PDB IDs		1PME 1TVO 1WZY 2OJG 2OJI 2OJJ 2Y9Q 3D42 3D44 3I5Z 3I60 3SA0 3TEI 3W55 4FMQ 4FUX 4FUY 4FV0 4FV1 4FV2 4FV3 4FV4 4FV5 4FV6 4FV7 4FV8 4FV9 4G6N 4G6O 4H3P 4H3Q 4IZ5 4IZ7 4IZA 4N0S 4NIF 4O6E 4QP1 4QP2 4QP3 4QP4 4QP6 4QP7 4QP8 4QP9 4QPA 4QTA 4QTE 4XJ0 4ZXT 4ZZM 4ZZN 4ZZO 5AX3 5BUE 5BUI 5BUJ 5BVD 5BVE 5BVF 5K4I 5LCJ 5LCK 5NGU 5NHF 5NHH 5NHJ 5NHL 5NHO 5NHP 5NHV 5V60 5V61 5V62 5WP1 6D5Y 6DMG 6G54 6G8X 6G91 6G92 6G93 6G97 6G9A 6G9D 6G9H 6G9J 6G9K 6G9M 6G9N 6GDM 6GDQ 6GE0 6GJB 6GJD 6NBS 6OPG 6OPH 6OPI 6Q7K 6Q7S 6Q7T 6QA1 6QA3 6QA4 6QAG 6QAH 6QAL 6QAQ 6QAW 6RQ4 6SLG 7AUV 7E73 7E75 7NQQ 7NQW 7NR3 7NR5 7NR8 7NR9 7OPM 7W5O 7X4U 7XC1 8AO2 8AO3 8AO4 8AO5 8AO6 8AO7 8AO8 8AO9 8AOA 8AOB 8AOC 8AOD 8AOE 8AOF 8AOG 8AOH 8AOI 8AOJ 8PSR 8PST 8PSW 8PSY 8PT0 8PT1 8PT3 8PT5 8PVU 8R5F 8U8J 8U8K 8ZJV	1R28 1R29 1R2B 2EN2 2EOS 2LCE 2YRM 3BIM 3E4U 3LBZ 4CP3 4U2M 5H7G 5H7H 5MW2 5MW6 5MWD 5N1X 5N1Z 5N20 5N21 5X4M 5X4N 5X4O 5X4P 5X4Q 5X9O 5X9P 6C3L 6C3N 6CQ1 6EW6 6EW7 6EW8 6TBT 6TCJ 6TOF 6TOG 6TOH 6TOI 6TOJ 6TOK 6TOL 6TOM 6TON 6TOO 6XMX 6XWF 6XXS 6XYX 6XZZ 6Y17 6ZBU 7BDE 7GUD 7GUE 7GUF 7GUG 7GUH 7GUI 7GUJ 7GUK 7GUL 7GUM 7GUN 7GUO 7GUP 7GUQ 7GUR 7GUS 7GUT 7GUU 7GUV 7GUW 7GUX 7GUY 7GUZ 7GV0 7GV1 7GV2 7GV3 7GV4 7GV5 7GV6 7GV7 7GV8 7GV9 7GVA 7GVB 7GVC 7GVD 7GVE 7GVF 7GVG 7GVH 7GVI 7GVJ 7GVK 7GVL 7GVM 7GVN 7GVO 7GVP 7GVQ 7GVR 7GVS 7GVT 7GVU 7GVV 7GVW 7GVX 7GVY 7GVZ 7GW0 7GW1 7GW2 7GW3 7GW4 7GW5 7GW6 7GW7 7GW8 7GW9 7GWA 7GWB 7GWC 7GWD 7GWE 7GWF 7GWG 7GWH 7GWI 7GWJ 7GWK 7GWL 7GWM 7GWN 7GWO 7GWP 7GWQ 7GWR 7GWS 7GWT 7GWU 7GWV 7GWW 7GWX 7GWY 7GWZ 7GX0 7GX1 7GX2 7GX3 7GX4 7GX5 7GX6 7GX7 7GX8 7GX9 7GXA 7GXB 7GXC 7GXD 7GXE 7GXF 7GXG 7GXH 7GXI 7GXJ 7GXK 7GXL 7GXM 7GXN 7GXO 7GXP 7GXQ 7GXR 7GXS 7GXT 7GXU 7GXV 7GXW 7GXX 7GXY 7GXZ 7GY0 7GY1 7GY2 7GY3 7LWE 7LWF 7LWG 7LZQ 7LZR 7LZS 7OKD 7OKE 7OKF 7OKG 7OKH 7OKI 7OKJ 7OKK 7OKL 7OKM 7Q7R 7Q7S 7Q7T 7Q7U 7Q7V 7QK0 7RUW 7RUX 7RUY 7RUZ 7RV0 7RV1 7RV2 7RV3 7RV4 7RV5 7RV6 7RV7 7RV8 7RV9 7T0S 7T0T 7T0U 7ZWN 7ZWO 7ZWP 7ZWQ 7ZWR 7ZWS 7ZWT 7ZWU 7ZWV 7ZWW 7ZWX 7ZWY 7ZWZ 8AS9 8C78
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Signal Transduction Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Apoptotic Process Regulation Of Programmed Cell Death MAPK Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Intracellular Signaling Cassette Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cytosol Regulation Of Multicellular Organismal Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Response To Hormone Cytoplasm Nucleus Negative Regulation Of Metabolic Process Response To Lipid Nucleoplasm Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Cellular Response To Oxygen-containing Compound Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Signal Transduction DNA-binding Transcription Factor Activity	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding Transcription Repressor Complex DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Transcription Corepressor Activity Regulation Of Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Nucleoplasm Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Regulator Complex Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Macromolecule Biosynthetic Process Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Histone Deacetylase Complex Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Process Protein Lysine Deacetylase Activity Transcription Corepressor Binding Positive Regulation Of Metabolic Process Transcription Coactivator Binding Chromatin Organization Negative Regulation Of Developmental Process
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