Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
MAPK1 and NKX2-1
Number of citations of the paper that reports this interaction (PMID
10733581
)
10
Data Source:
HPRD
(in vitro, in vivo)
MAPK1
NKX2-1
Gene Name
mitogen-activated protein kinase 1
NK2 homeobox 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Early Endosome
Late Endosome
Golgi Apparatus
Microtubule Organizing Center
Cytosol
Cytoskeleton
Caveola
Focal Adhesion
Microtubule Cytoskeleton
Axon
Pseudopodium
Dendrite Cytoplasm
Perikaryon
Protein Complex
Extracellular Vesicular Exosome
Mitotic Spindle
Nucleus
Nucleoplasm
Transcription Factor Complex
Molecular Function
Phosphotyrosine Binding
DNA Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
RNA Polymerase II Carboxy-terminal Domain Kinase Activity
Phosphatase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Core Promoter Binding
Intronic Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Enzyme Binding
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Biological Process
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
MAPK Import Into Nucleus
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Transcription, DNA-templated
Apoptotic Process
Chemotaxis
Response To Stress
Cellular Response To DNA Damage Stimulus
Cell Cycle
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Ras Protein Signal Transduction
Synaptic Transmission
Axon Guidance
Blood Coagulation
Positive Regulation Of Cell Proliferation
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Toxic Substance
Organ Morphogenesis
Positive Regulation Of Peptidyl-threonine Phosphorylation
Viral Process
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Sensory Perception Of Pain
Cytosine Metabolic Process
Platelet Activation
Positive Regulation Of Cell Migration
Regulation Of Protein Stability
Lipopolysaccharide-mediated Signaling Pathway
Regulation Of Stress-activated MAPK Cascade
Mammary Gland Epithelial Cell Proliferation
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Cellular Response To Heat
TRIF-dependent Toll-like Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
ERBB Signaling Pathway
Response To Exogenous DsRNA
Response To Estrogen
Innate Immune Response
Negative Regulation Of Cell Differentiation
Positive Regulation Of Translation
Positive Regulation Of Transcription, DNA-templated
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Stress-activated MAPK Cascade
Regulation Of Cytoskeleton Organization
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Labyrinthine Layer Blood Vessel Development
ERK1 And ERK2 Cascade
Response To Epidermal Growth Factor
Caveolin-mediated Endocytosis
Regulation Of Golgi Inheritance
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Regulation Of Cellular Response To Heat
Regulation Of Early Endosome To Late Endosome Transport
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Neuron Migration
Transcription From RNA Polymerase II Promoter
Phospholipid Metabolic Process
Axon Guidance
Brain Development
Endoderm Development
Locomotory Behavior
Response To Hormone
Positive Regulation Of Gene Expression
Negative Regulation Of Epithelial To Mesenchymal Transition
Globus Pallidus Development
Hippocampus Development
Cerebral Cortex Cell Migration
Forebrain Dorsal/ventral Pattern Formation
Forebrain Neuron Fate Commitment
Cerebral Cortex GABAergic Interneuron Differentiation
Pituitary Gland Development
Lung Development
Negative Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Thyroid Gland Development
Forebrain Development
Developmental Induction
Leydig Cell Differentiation
Positive Regulation Of Circadian Rhythm
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Rhythmic Process
Anatomical Structure Formation Involved In Morphogenesis
Oligodendrocyte Differentiation
Lung Saccule Development
Epithelial Tube Branching Involved In Lung Morphogenesis
Clara Cell Differentiation
Type II Pneumocyte Differentiation
Pathways
phospho-PLA2 pathway
Ca-dependent events
Signaling by FGFR in disease
Cellular Senescence
ERKs are inactivated
CREB phosphorylation through the activation of Ras
Signaling by EGFRvIII in Cancer
Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor 5 (TLR5) Cascade
Gastrin-CREB signalling pathway via PKC and MAPK
MyD88 dependent cascade initiated on endosome
SOS-mediated signalling
Fcgamma receptor (FCGR) dependent phagocytosis
SHC-mediated signalling
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Regulation of actin dynamics for phagocytic cup formation
TRIF-mediated TLR3/TLR4 signaling
Senescence-Associated Secretory Phenotype (SASP)
Signaling by VEGF
Signalling to RAS
Downstream signal transduction
Toll Like Receptor 3 (TLR3) Cascade
Interleukin-2 signaling
Platelet activation, signaling and aggregation
Frs2-mediated activation
Transmission across Chemical Synapses
Axon guidance
IRS-mediated signalling
L1CAM interactions
Oncogene Induced Senescence
VEGFA-VEGFR2 Pathway
Activated TLR4 signalling
VEGFR2 mediated cell proliferation
GRB2 events in ERBB2 signaling
RSK activation
Activation of NMDA receptor upon glutamate binding and postsynaptic events
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88:Mal cascade initiated on plasma membrane
NCAM signaling for neurite out-growth
Signalling to p38 via RIT and RIN
RAF/MAP kinase cascade
Innate Immune System
Signaling by Insulin receptor
ERKs are inactivated
Signal transduction by L1
Insulin receptor signalling cascade
PLC beta mediated events
IRS-related events
Signaling by Ligand-Responsive EGFR Variants in Cancer
SHC-related events
G-protein mediated events
Signaling by FGFR
Thrombin signalling through proteinase activated receptors (PARs)
ARMS-mediated activation
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Signal attenuation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
ERK/MAPK targets
MAPK targets/ Nuclear events mediated by MAP kinases
Signaling by GPCR
Mitotic Prophase
Golgi Cisternae Pericentriolar Stack Reorganization
FCERI mediated MAPK activation
Signaling by SCF-KIT
SHC1 events in ERBB2 signaling
DAP12 signaling
Toll Like Receptor 9 (TLR9) Cascade
ERK/MAPK targets
Negative regulation of FGFR signaling
Signaling by PDGF
DAP12 interactions
Opioid Signalling
SHC-related events triggered by IGF1R
GRB2 events in EGFR signaling
Signaling by ERBB4
Toll Like Receptor 2 (TLR2) Cascade
Signaling by ERBB2
Signaling by EGFR
Signaling by Interleukins
SHC1 events in ERBB4 signaling
Toll Like Receptor 4 (TLR4) Cascade
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
Signaling by Leptin
Growth hormone receptor signaling
Signalling to ERKs
Prolonged ERK activation events
ERK activation
Toll Like Receptor 7/8 (TLR7/8) Cascade
IGF1R signaling cascade
Recycling pathway of L1
M Phase
Toll Like Receptor TLR6:TLR2 Cascade
IRS-related events triggered by IGF1R
Activation of the AP-1 family of transcription factors
MyD88 cascade initiated on plasma membrane
ERK activation
Downstream signaling of activated FGFR
Advanced glycosylation endproduct receptor signaling
Post NMDA receptor activation events
Signalling by NGF
SOS-mediated signalling
MAP kinase activation in TLR cascade
SHC-mediated signalling
Cytokine Signaling in Immune system
Cellular response to heat stress
Regulation of HSF1-mediated heat shock response
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Signaling by Overexpressed Wild-Type EGFR in Cancer
Cell Cycle, Mitotic
ERK2 activation
SHC1 events in EGFR signaling
FRS2-mediated cascade
IRS-mediated signalling
Oxidative Stress Induced Senescence
ERK2 activation
Nuclear Events (kinase and transcription factor activation)
Drugs
Isoproterenol
Arsenic trioxide
Olomoucine
Phosphonothreonine
Purvalanol
SB220025
N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE
(S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
(3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE
5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE
(1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione
[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE
Diseases
GWAS
Inflammatory bowel disease (
23128233
)
Multiple sclerosis (
21833088
)
Height (
18391950
)
Menarche (age at onset) (
23667675
)
Thyroid cancer (
19198613
)
Protein-Protein Interactions
213 interactors:
AR
ARRB1
ARRB2
ATF2
ATP1A1
BCL2
BCL6
BRAF
C1QBP
CACYBP
CAD
CALCOCO1
CAPN2
CASP8
CASP9
CAV1
CD19
CDC25C
CDT1
CDX2
CEBPB
CEP55
CMTM3
CREBBP
CRP
CTSD
CUEDC2
DAPK1
DUSP1
DUSP16
DUSP2
DUSP3
DUSP4
DUSP5
DUSP6
DUSP7
DUSP9
DYRK1B
EGFR
EGLN3
EIF4EBP1
ELK1
ENAH
EP300
EPOR
ERF
ESR1
ESR2
ETS1
FCGR2B
FHL3
FOS
FOXO3
FRS2
FRS3
GAB1
GAB2
GABRR1
GAPDH
GATA1
GATA2
GATA4
GJA1
GMFB
GNPTAB
GORASP2
GRB10
GRB2
GSK3B
HDAC4
HIF1A
HNF4A
HSF1
HSF4
HSP90AA1
ID2
IER3
IFI35
IFNAR1
IQGAP1
IRS1
ITGB6
JUN
JUND
KARS
KHDRBS1
KLF11
KRT8
KSR1
KSR2
LAMTOR3
LCK
LIFR
LIPE
LRPAP1
MAFA
MAP2K1
MAP2K2
MAP2K4
MAP2K6
MAP2K7
MAP3K1
MAP3K10
MAPK14
MAPK8
MAPKAPK2
MAPKAPK5
MBP
MCL1
METAP2
MITF
MKNK1
MKNK2
MTIF3
MTPN
MYB
MYC
NCOA1
NCOA3
NDE1
NEFH
NEK2
NGFR
NKX2-1
NOXA1
NR3C1
NR4A1
NR5A1
NTRK3
NUP153
PAK1
PAK2
PDE4D
PEA15
PEBP1
PLAT
PLCB1
PLK3
PPARA
PPARG
PPP1CA
PPP1R9B
PPP2CA
PPP2R5B
PPP2R5C
PRKCD
PRKCE
PRKCZ
PRPSAP1
PTPN1
PTPN5
PTPN7
PTPRE
PTPRH
PTPRR
PXN
RAF1
RB1
RET
RGS19
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KB1
RPTOR
RXRA
SCNN1G
SH2D1A
SH2D3C
SHANK3
SHC1
SLC9A1
SMAD1
SMAD2
SMAD3
SMAD4
SNCA
SNCG
SORBS3
SOS1
SP1
SREBF1
SREBF2
STAT3
STAT5A
STAT5B
SUPT20H
TCF3
TFCP2
TGIF1
TH
TIAL1
TNFRSF1A
TNFRSF25
TNFSF11
TNIP1
TNIP2
TNKS2
TOB1
TOP2A
TP53
TPR
TSC2
TTN
UBR5
UBTF
VAV1
VDR
YBX1
YBX3
ZC3HC1
ZFP36
14 interactors:
CALR
CREBBP
GATA6
HIPK2
MAPK1
NCOA1
NCOA2
NCOA3
PAX8
PTRF
RARA
RELA
TDG
WWTR1
Entrez ID
5594
7080
HPRD ID
01496
02798
Ensembl ID
ENSG00000100030
ENSG00000136352
Uniprot IDs
P28482
Q1HBJ4
Q499G7
P43699
PDB IDs
1PME
1TVO
1WZY
2OJG
2OJI
2OJJ
2Y9Q
3D42
3D44
3I5Z
3I60
3SA0
3TEI
3W55
4FMQ
4FUX
4FUY
4FV0
4FV1
4FV2
4FV3
4FV4
4FV5
4FV6
4FV7
4FV8
4FV9
4G6N
4G6O
4H3P
4H3Q
4IZ5
4IZ7
4IZA
Enriched GO Terms of Interacting Partners
?
Response To Organic Substance
Cellular Response To Organic Substance
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Metabolic Process
Cellular Response To Stimulus
Regulation Of Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Signaling
Regulation Of Signaling
Cell Communication
Response To Stimulus
Signal Transduction
Response To Stress
Regulation Of Protein Metabolic Process
Intracellular Signal Transduction
Regulation Of Metabolic Process
Response To Growth Factor
Cellular Response To Growth Factor Stimulus
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Gene Expression
Regulation Of Immune System Process
Positive Regulation Of Macromolecule Biosynthetic Process
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Cellular Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Immune Response
Regulation Of Transcription From RNA Polymerase II Promoter
Defense Response
Developmental Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cellular Metabolic Process
Anatomical Structure Development
Regulation Of Phosphorylation
Positive Regulation Of Transcription, DNA-templated
Multicellular Organismal Development
Immune Response-regulating Signaling Pathway
Positive Regulation Of Signal Transduction
Response To Hormone
MAPK Cascade
Apoptotic Process
Immune System Process
Regulation Of Cell Death
Response To Abiotic Stimulus
Cell Death
Programmed Cell Death
Death
Signal Transduction By Phosphorylation
Regulation Of Phosphorus Metabolic Process
Organ Development
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Macromolecule Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
RNA Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of RNA Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Response To Organic Substance
Biosynthetic Process
Regulation Of Gene Expression
Cellular Response To Hormone Stimulus
Regulation Of Nitrogen Compound Metabolic Process
Response To Hormone
Intracellular Receptor Signaling Pathway
Regulation Of Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Embryo Development
Gland Development
Response To Organic Substance
Positive Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Cell Differentiation
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Organ Morphogenesis
Embryonic Morphogenesis
Nitrogen Compound Metabolic Process
Intracellular Steroid Hormone Receptor Signaling Pathway
Tissue Development
Anatomical Structure Morphogenesis
Response To Estrogen
Regulation Of Metabolic Process
Response To Steroid Hormone
Positive Regulation Of Cell Proliferation
Tagcloud
?
ac
analysing
bioinformatics
boolean
david
hijacks
host
ikka
ikkb
ikky
interrupts
intersected
jean
knockouts
logical
lose
manchester
marc
modelling
motivation
perturbation
perturbs
replicate
reproduced
robertson
schwartz
silico
supplementary
uk
Tagcloud (Difference)
?
ac
analysing
bioinformatics
boolean
david
hijacks
host
ikka
ikkb
ikky
interrupts
intersected
jean
knockouts
logical
lose
manchester
marc
modelling
motivation
perturbation
perturbs
replicate
reproduced
robertson
schwartz
silico
supplementary
uk
Tagcloud (Intersection)
?