ZC4H2 and PRPH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZC4H2	PRPH
Description		zinc finger C4H2-type containing	peripherin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane Protein-containing Complex Neuronal Cell Body Synapse Postsynaptic Membrane	Cytoplasm Cytoskeleton Intermediate Filament Plasma Membrane Membrane Axon Cell Projection Perikaryon Type III Intermediate Filament Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Noradrenergic Neuron Development Protein Monoubiquitination Nervous System Development Neuromuscular Junction Development Spinal Cord Motor Neuron Differentiation Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Transcription Regulatory Region DNA Binding	Intermediate Filament Organization
Pathways
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Male-pattern baldness ( 28196072)	Prostate cancer ( 21743467) Sural nerve amplitude potential ( 30992453)
Interacting Genes		22 interacting genes: ATP4B CMIP DGCR6 FAM161B GCC1 GEM HOXB5 KXD1 MECOM PLEKHN1 PRPH RNF151 SORBS3 TRIM14 ZNF223 ZNF250 ZNF408 ZNF490 ZNF524 ZNF669 ZNF688 ZNF76	34 interacting genes: CDC37 CT55 DDX6 DES FCHO1 INCA1 KIFC3 KRT14 KRT15 KRT16 KRT20 KRT24 KRT27 KRT31 LCA5L LENG1 LMNB1 LNX1 MAGOHB MYO5A NXF1 PIAS2 PPP1R13B PPP1R18 PRKAA2 PRPH2 PSMA1 TCEA2 TCP10L TTC23 VIM ZC4H2 ZMAT2 ZNF572
Entrez ID		55906	5630
HPRD ID		06584	01365
Ensembl ID		ENSG00000126970	ENSG00000135406
Uniprot IDs		Q9NQZ6	B3KWQ6 P41219
PDB IDs
Enriched GO Terms of Interacting Partners?		Zinc Ion Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleus	Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Structural Constituent Of Skin Epidermis Structural Constituent Of Cytoskeleton Keratin Filament Supramolecular Fiber Organization Structural Molecule Activity Morphogenesis Of An Epithelium Tissue Morphogenesis Cytoskeleton Organization Epithelial Cell Differentiation Keratin Filament Binding Cytoskeleton Extracellular Exosome Intermediate Filament Cytoskeleton Epidermis Development Protein Binding Organelle Organization Hair Cycle Scaffold Protein Binding Cytoplasmic Stress Granule Nuclear Envelope Organization
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