PDCD1 and CD274

Number of citations of the paper that reports this interaction (PMID 12719480)
50

Data Source:
HPRD (in vivo)

		PDCD1	CD274
Gene Name		programmed cell death 1	CD274 molecule
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Plasma Membrane External Side Of Plasma Membrane Endomembrane System Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity Protein Binding	Protein Binding
	Biological Process	Apoptotic Process Humoral Immune Response Signal Transduction Multicellular Organismal Development T Cell Costimulation Positive Regulation Of T Cell Apoptotic Process	Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway T Cell Costimulation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of T Cell Proliferation Regulation Of Activated T Cell Proliferation Negative Regulation Of Activated T Cell Proliferation Regulation Of T Cell Apoptotic Process Toxin Transport Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Interleukin-10 Secretion
Pathways		Costimulation by the CD28 family PD-1 signaling Adaptive Immune System	Costimulation by the CD28 family PD-1 signaling Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: CD274 PDCD1LG2	2 interactors: CD80 PDCD1
Entrez ID		5133	29126
HPRD ID		02590	05655
Ensembl ID		ENSG00000188389	ENSG00000120217
Uniprot IDs		Q15116	Q0GN75 Q2V8D5 Q9NZQ7
PDB IDs		2M2D 3RRQ	3BIK 3BIS 3FN3 3SBW
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interferon-gamma Production Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Proliferation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation T Cell Costimulation Negative Regulation Of Leukocyte Proliferation Positive Regulation Of T Cell Proliferation Regulation Of Interferon-gamma Production Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Regulation Of T Cell Proliferation Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell Adhesion Negative Regulation Of Cytokine Production Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Negative Regulation Of Immune System Process Regulation Of Lymphocyte Activation Regulation Of Cell Activation Regulation Of Cytokine Production Regulation Of Cell Adhesion Negative Regulation Of Cell Proliferation Positive Regulation Of Interleukin-10 Secretion Positive Regulation Of Cell Proliferation Positive Regulation Of Immune System Process Regulation Of Interleukin-10 Secretion Positive Regulation Of Interleukin-10 Production Immune Response Regulation Of Immune System Process Toxin Transport Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Cell Proliferation Positive Regulation Of Cytokine Secretion Immune System Process Regulation Of Cytokine Secretion Positive Regulation Of Protein Secretion Positive Regulation Of Secretion	T Cell Costimulation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Regulation Of Cell Activation Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Regulation Of Cell Adhesion Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of Immune System Process Positive Regulation Of Lymphocyte Apoptotic Process Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of T-helper Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Leukocyte Apoptotic Process Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of T-helper Cell Differentiation Positive Regulation Of Interleukin-2 Production Immune Response Regulation Of Immune System Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Regulation Of T Cell Apoptotic Process Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Cytokine Biosynthetic Process Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Immune System Process Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Differentiation Phosphatidylinositol-mediated Signaling Regulation Of T Cell Proliferation Positive Regulation Of Adaptive Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Lymphocyte Differentiation Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		2c chordin chrdl2 desmin eya2 galectin granulin igfs listed mef2c msh msx1 myocyte myogenesis numb nuprl pax3 pax7 pbx1 programmed pseudospiralis r1 rb1 retinoblastoma satellite ski spiralis trichinella	9p24 actionable arid1a atlas barr bystander cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite mlh1 msi noncoding pdcd1lg2 qualify
Tagcloud (Difference) ?		2c chordin chrdl2 desmin eya2 galectin granulin igfs listed mef2c msh msx1 myocyte myogenesis numb nuprl pax3 pax7 pbx1 programmed pseudospiralis r1 rb1 retinoblastoma satellite ski spiralis trichinella	9p24 actionable arid1a atlas barr bystander cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite mlh1 msi noncoding pdcd1lg2 qualify
Tagcloud (Intersection) ?