PDCD1 and PDCD1LG2

Number of citations of the paper that reports this interaction (PMID 12893276)
17

Data Source:
BioGRID (pull down)

		PDCD1	PDCD1LG2
Gene Name		programmed cell death 1	programmed cell death 1 ligand 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Plasma Membrane Endomembrane System Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity Protein Binding	Molecular_function
	Biological Process	Apoptotic Process Humoral Immune Response Signal Transduction Multicellular Organismal Development T Cell Costimulation Positive Regulation Of T Cell Apoptotic Process	Immune Response T Cell Costimulation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of T Cell Proliferation Negative Regulation Of Activated T Cell Proliferation
Pathways		Costimulation by the CD28 family PD-1 signaling Adaptive Immune System	Costimulation by the CD28 family PD-1 signaling Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: CD274 PDCD1LG2	1 interactors: PDCD1
Entrez ID		5133	80380
HPRD ID		02590	16147
Ensembl ID		ENSG00000188389	ENSG00000197646
Uniprot IDs		Q15116	Q9BQ51
PDB IDs		2M2D 3RRQ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interferon-gamma Production Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Proliferation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation T Cell Costimulation Negative Regulation Of Leukocyte Proliferation Positive Regulation Of T Cell Proliferation Regulation Of Interferon-gamma Production Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Regulation Of T Cell Proliferation Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell Adhesion Negative Regulation Of Cytokine Production Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Negative Regulation Of Immune System Process Regulation Of Lymphocyte Activation Regulation Of Cell Activation Regulation Of Cytokine Production Regulation Of Cell Adhesion Negative Regulation Of Cell Proliferation Positive Regulation Of Interleukin-10 Secretion Positive Regulation Of Cell Proliferation Positive Regulation Of Immune System Process Regulation Of Interleukin-10 Secretion Positive Regulation Of Interleukin-10 Production Immune Response Regulation Of Immune System Process Toxin Transport Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Cell Proliferation Positive Regulation Of Cytokine Secretion Immune System Process Regulation Of Cytokine Secretion Positive Regulation Of Protein Secretion Positive Regulation Of Secretion	Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Leukocyte Apoptotic Process Regulation Of T Cell Apoptotic Process Regulation Of Lymphocyte Apoptotic Process T Cell Costimulation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Humoral Immune Response Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cell Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cell Adhesion
Tagcloud ?		2c chordin chrdl2 desmin eya2 galectin granulin igfs listed mef2c msh msx1 myocyte myogenesis numb nuprl pax3 pax7 pbx1 programmed pseudospiralis r1 rb1 retinoblastoma satellite ski spiralis trichinella	9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite mlh1 msi noncoding qualify
Tagcloud (Difference) ?		2c chordin chrdl2 desmin eya2 galectin granulin igfs listed mef2c msh msx1 myocyte myogenesis numb nuprl pax3 pax7 pbx1 programmed pseudospiralis r1 rb1 retinoblastoma satellite ski spiralis trichinella	9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite mlh1 msi noncoding qualify
Tagcloud (Intersection) ?