PDCD1

Description		programmed cell death 1
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Protein Binding Signaling Receptor Activity
	Biological Process	B Cell Apoptotic Process Adaptive Immune Response Immune System Process Negative Regulation Of Tolerance Induction Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of B Cell Apoptotic Process Apoptotic Process Humoral Immune Response Regulation Of Immune Response Negative Regulation Of Immune Response Negative Regulation Of T Cell Activation Negative Regulation Of Multicellular Organismal Process Positive Regulation Of T Cell Apoptotic Process Regulatory T Cell Apoptotic Process
Pathways		Co-inhibition by PD-1 Potential therapeutics for SARS PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs		CT-011 Nivolumab Pembrolizumab Atezolizumab Durvalumab Avelumab Cemiplimab Camrelizumab Spartalizumab Tislelizumab Toripalimab Dostarlimab Sintilimab Retifanlimab AMP-224 MEDI0680 Geptanolimab Budigalimab Prolgolimab
Diseases		Systemic lupus erythematosus
GWAS		Crohn's disease ( 26192919) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494)
Novel Interacting Genes		3 novel interacting genes: COPS8 MCL1 OR6B3
Interacting Genes		8 interacting genes: CD274 MAPK3 MDM2 PDCD1LG2 RNF128 RNF130 RNF167 USP5
Entrez ID		5133
HPRD ID		02590
Ensembl ID		ENSG00000188389
Uniprot IDs		A0A0M3M0G7 Q15116
PDB IDs		2M2D 3RRQ 4ZQK 5B8C 5GGR 5GGS 5IUS 5JXE 5WT9 6HIG 6J14 6J15 6JBT 6JJP 6K0Y 6R5G 6ROY 6ROZ 6UMT 6UMU 6UMV 6XKR 7BXA 7CGW 7CU5 7E9B 7VUX 7WSL 7WVM 8AS0 8EQ6 8GY5 8U31 8U32 9HK1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Immune Response To Tumor Cell Regulation Of T Cell Mediated Immune Response To Tumor Cell Regulation Of Response To Tumor Cell Protein Modification By Small Protein Conjugation Negative Regulation Of T Cell Activation Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Lymphocyte Activation Post-translational Protein Modification Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Activation Negative Regulation Of Adaptive Immune Response Protein Modification Process Endomembrane System Protein Ubiquitination Negative Regulation Of Cell Adhesion Negative Regulation Of Activated T Cell Proliferation Regulation Of T Cell Mediated Immunity Ubiquitin Protein Ligase Activity Regulation Of Protein Stability Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Proteolysis Negative Regulation Of Interleukin-10 Production Positive Regulation Of Leukocyte Proliferation Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Mediated Immunity Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Immune System Process Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Immune Response Regulation Of Adaptive Immune Response Regulation Of Activated T Cell Proliferation Negative Regulation Of Type II Interferon Production Modification-dependent Protein Catabolic Process T Cell Costimulation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Metabolic Process Cellular Response To Nutrient Levels
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