SCOC and SIKE1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SCOC	SIKE1
Description		short coiled-coil protein	suppressor of IKBKE 1
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GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Cytosol Membrane	Cytoplasm Cytosol FAR/SIN/STRIPAK Complex
	Molecular Function	Protein Binding	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Small GTPase Binding
	Biological Process	Positive Regulation Of Macroautophagy Regulation Of Protein Complex Stability	Negative Regulation Of Hippo Signaling
Pathways		Retrograde transport at the Trans-Golgi-Network	TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Malaria ( 31844061) Smoking status (ever vs never smokers) ( 30643258)	Age at first sexual intercourse ( 34211149)
Interacting Genes		14 interacting genes: ARL1 BFSP2 DDIT4L DOK5 FEZ1 ITSN1 KIFC3 KRT40 MAPK8 PSMC5 SCHIP1 SIKE1 TCF4 TRAPPC6A	13 interacting genes: CBFA2T2 CENPQ CTAG1A CTAG1B IKBKE NTAQ1 SCOC STRN3 STX11 TBK1 TXLNA TXLNB ZC2HC1C
Entrez ID		60592	80143
HPRD ID		18027	07958
Ensembl ID		ENSG00000153130	ENSG00000052723
Uniprot IDs		A0A0C4DGB0 A0A804E055 Q9UIL1	Q9BRV8
PDB IDs		4BWD 7AA7	6AKK 6AKL 6AKM
Enriched GO Terms of Interacting Partners?			TRNA Threonylcarbamoyladenosine Metabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Serine/threonine Protein Kinase Complex Type I Interferon-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Protein-N-terminal Glutamine Amidohydrolase Activity Syntaxin Binding Positive Regulation Of Cytokine-mediated Signaling Pathway Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Protein-N-terminal Asparagine Amidohydrolase Activity Positive Regulation Of Protein Localization To Kinetochore
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