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ST6GALNAC1 and EXOSC2
Number of citations of the paper that reports this interaction (PMID
15231747
)
44
Data Source:
BioGRID
(two hybrid)
ST6GALNAC1
EXOSC2
Gene Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
exosome component 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Integral Component Of Membrane
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleolus
Cytoplasm
Cytosol
Molecular Function
Alpha-N-acetylgalactosaminide Alpha-2,6-sialyltransferase Activity
Sialyltransferase Activity
3'-5'-exoribonuclease Activity
Exoribonuclease Activity
Protein Binding
7S RNA Binding
Biological Process
Protein Glycosylation
Dolichol-linked Oligosaccharide Biosynthetic Process
Oligosaccharide Biosynthetic Process
Protein N-linked Glycosylation Via Asparagine
Post-translational Protein Modification
Cellular Protein Metabolic Process
Sialylation
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
RRNA Processing
Gene Expression
Positive Regulation Of Cell Growth
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U4 SnRNA 3'-end Processing
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
CUT Catabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
Polyadenylation-dependent SnoRNA 3'-end Processing
Pathways
Diseases of glycosylation
Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
Defective MGAT2 causes MGAT2-CDG (CDG-2a)
Defective ALG1 causes ALG1-CDG (CDG-1k)
Defective MOGS causes MOGS-CDG (CDG-2b)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective ALG9 causes ALG9-CDG (CDG-1l)
Defective MAN1B1 causes MRT15
Defective ALG11 causes ALG11-CDG (CDG-1p)
Defective ALG2 causes ALG2-CDG (CDG-1i)
Post-translational protein modification
Defective ALG3 causes ALG3-CDG (CDG-1d)
Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
Synthesis of substrates in N-glycan biosythesis
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective ALG6 causes ALG6-CDG (CDG-1c)
Defective RFT1 causes RFT1-CDG (CDG-1n)
Asparagine N-linked glycosylation
Defective ALG8 causes ALG8-CDG (CDG-1h)
Sialic acid metabolism
Defective MPDU1 causes MPDU1-CDG (CDG-1f)
Defective ALG12 causes ALG12-CDG (CDG-1g)
Diseases associated with N-glycosylation of proteins
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions
1 interactors:
EXOSC2
16 interactors:
DIS3
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
EXOSC9
GALNT13
KHSRP
MPP6
MRPL48
RNF8
SKIV2L2
ST6GALNAC1
UPF1
ZNF408
Entrez ID
55808
23404
HPRD ID
15340
03758
Ensembl ID
ENSG00000070526
ENSG00000130713
Uniprot IDs
Q9NSC7
Q9NXQ7
B3KQW2
Q13868
PDB IDs
2NN6
Enriched GO Terms of Interacting Partners
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Nuclear Polyadenylation-dependent TRNA Catabolic Process
U4 SnRNA 3'-end Processing
Polyadenylation-dependent SnoRNA 3'-end Processing
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
TRNA Catabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
SnoRNA Metabolic Process
Nuclear MRNA Surveillance
RRNA 3'-end Processing
RNA Surveillance
Intracellular MRNA Localization
RRNA Catabolic Process
Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Maturation Of 5.8S RRNA
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
SnRNA Processing
SnRNA Metabolic Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RNA 3'-end Processing
RNA Phosphodiester Bond Hydrolysis
Positive Regulation Of Cell Growth
RRNA Processing
RRNA Metabolic Process
Nuclear-transcribed MRNA Catabolic Process
RNA Localization
MRNA Catabolic Process
RNA Catabolic Process
Ribosome Biogenesis
Positive Regulation Of Growth
TRNA Metabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Ribonucleoprotein Complex Biogenesis
Regulation Of Cell Growth
Aromatic Compound Catabolic Process
NcRNA Metabolic Process
MRNA Metabolic Process
RNA Processing
Regulation Of Growth
Cellular Macromolecule Catabolic Process
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
RRNA Processing
RRNA Metabolic Process
MRNA Catabolic Process
RNA Catabolic Process
Ribosome Biogenesis
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process
Ribonucleoprotein Complex Biogenesis
MRNA Metabolic Process
Aromatic Compound Catabolic Process
NcRNA Metabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Cellular Macromolecule Catabolic Process
RNA Phosphodiester Bond Hydrolysis
DNA Deamination
Catabolic Process
RNA Metabolic Process
Gene Expression
Nucleobase-containing Compound Metabolic Process
Maturation Of 5.8S RRNA
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Nitrogen Compound Metabolic Process
Nuclear MRNA Surveillance
RNA Surveillance
Histone MRNA Catabolic Process
DNA Modification
RRNA Catabolic Process
Histone MRNA Metabolic Process
Isotype Switching
Metabolic Process
Somatic Recombination Of Immunoglobulin Gene Segments
Somatic Diversification Of Immunoglobulins
Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response
B Cell Activation Involved In Immune Response
DNA Metabolic Process
Immunoglobulin Production
Histone H2A K63-linked Ubiquitination
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
Positive Regulation Of Cell Growth
MRNA Transport
RNA Transport
RNA Localization
Leukocyte Activation Involved In Immune Response
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