ST6GALNAC1

Gene Name		ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Integral Component Of Membrane
	Molecular Function	Alpha-N-acetylgalactosaminide Alpha-2,6-sialyltransferase Activity Sialyltransferase Activity
	Biological Process	Protein Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process Sialylation
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: EXOSC2
Entrez ID		55808
HPRD ID		15340
Ensembl ID		ENSG00000070526
Uniprot IDs		Q9NSC7 Q9NXQ7
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear Polyadenylation-dependent TRNA Catabolic Process U4 SnRNA 3'-end Processing Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' TRNA Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Metabolic Process Nuclear MRNA Surveillance RRNA 3'-end Processing RNA Surveillance Intracellular MRNA Localization RRNA Catabolic Process Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of 5.8S RRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Phosphodiester Bond Hydrolysis, Exonucleolytic SnRNA Processing SnRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis Positive Regulation Of Cell Growth RRNA Processing RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process RNA Localization MRNA Catabolic Process RNA Catabolic Process Ribosome Biogenesis Positive Regulation Of Growth TRNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Ribonucleoprotein Complex Biogenesis Regulation Of Cell Growth Aromatic Compound Catabolic Process NcRNA Metabolic Process MRNA Metabolic Process RNA Processing Regulation Of Growth Cellular Macromolecule Catabolic Process
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