VPS29 and FRA10AC1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		VPS29	FRA10AC1
Description		VPS29 retromer complex component	FRA10A associated CGG repeat 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Late Endosome Cytosol Endosome Membrane Membrane Retromer Complex Retromer, Cargo-selective Complex	Nucleus
	Molecular Function	Protein Binding Metal Ion Binding	Protein Binding Phosphatase Activity
	Biological Process	Intracellular Protein Transport Regulation Of Autophagy Protein Transport Endocytic Recycling Retrograde Transport, Endosome To Golgi	MRNA Splicing, Via Spliceosome
Pathways		WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS			Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid AB1-42 levels ( 26252872 29274321) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: APP FRA10AC1 RGS2 SNCA TMCO4 VPS35	27 interacting genes: ADPRS C7orf25 CHERP CWC27 EEF1D GATD3 GDPD2 GLRX3 HABP4 IK KASH5 MAP3K12 MFAP1 MOB2 NKAP PLPPR4 PRPF3 PRPF40A SAP30BP SF3B2 THOC1 TRIM41 TTC14 U2AF1 VPS29 ZCCHC10 ZNF830
Entrez ID		51699	118924
HPRD ID		09499	12319
Ensembl ID		ENSG00000111237	ENSG00000148690
Uniprot IDs		A0A384MR19 F8VXU5 Q9UBQ0	Q70Z53
PDB IDs		1W24 2R17 5GTU 5OSH 5OSI 5WYH 6XS5 6XS7 6XS9 6XSA 7BLN 8ESE 8P0V 8P0X 8R02 8R0J 8RKS 8SYM 8SYN 8SYO 9AU7
Enriched GO Terms of Interacting Partners?		Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Dendritic Spine Maintenance Regulation Of Synapse Assembly Regulation Of Neurotransmitter Uptake Regulation Of Dopamine Metabolic Process Cellular Response To Copper Ion Regulation Of Long-term Neuronal Synaptic Plasticity Amyloid Fibril Formation Microglial Cell Activation Presynapse Response To Copper Ion Postsynapse Leukocyte Activation Involved In Inflammatory Response Regulation Of Cell Junction Assembly Beta-tubulin Binding Regulation Of Synapse Organization Regulation Of Neuronal Synaptic Plasticity Protein Destabilization Amyloid-beta Complex Growth Cone Lamellipodium Myeloid Cell Development Regulation Of Response To Calcium Ion Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Terminal Button Organization Regulation Of Amine Transport Positive Regulation Of Protein Localization To Cell Periphery Adult Locomotory Behavior Regulation Of Inflammatory Response Response To Interleukin-1 Negative Regulation Of Transport Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Protein Tetramerization Vesicle-mediated Transport In Synapse Acetylcholine Receptor Activator Activity Modulation Of Chemical Synaptic Transmission	RNA Splicing MRNA Processing U2-type Precatalytic Spliceosome MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing Nuclear Speck Spliceosomal Complex Nucleic Acid Metabolic Process RNA Metabolic Process Nucleoplasm RNA Binding Cajal Body Nucleobase-containing Compound Metabolic Process Catalytic Step 2 Spliceosome U2-type Spliceosomal Complex Glycerophosphoinositol Inositolphosphodiesterase Activity ADP-ribosylserine Hydrolase Activity Cellular Response To Superoxide Peptidyl-serine ADP-deribosylation Nucleus Nucleic Acid Binding
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