VPS29 and TMCO4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VPS29	TMCO4
Description		VPS29 retromer complex component	transmembrane and coiled-coil domains 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Late Endosome Cytosol Endosome Membrane Membrane Retromer Complex Retromer, Cargo-selective Complex	Membrane
	Molecular Function	Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Intracellular Protein Transport Regulation Of Autophagy Protein Transport Endocytic Recycling Retrograde Transport, Endosome To Golgi
Pathways		WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS			Late-onset Alzheimer's disease ( 27770636) Morning person ( 30696823)
Interacting Genes		6 interacting genes: APP FRA10AC1 RGS2 SNCA TMCO4 VPS35	1 interacting genes: VPS29
Entrez ID		51699	255104
HPRD ID		09499	14140
Ensembl ID		ENSG00000111237	ENSG00000162542
Uniprot IDs		A0A384MR19 F8VXU5 Q9UBQ0	Q5TGY1
PDB IDs		1W24 2R17 5GTU 5OSH 5OSI 5WYH 6XS5 6XS7 6XS9 6XSA 7BLN 8ESE 8P0V 8P0X 8R02 8R0J 8RKS 8SYM 8SYN 8SYO 9AU7
Enriched GO Terms of Interacting Partners?		Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Dendritic Spine Maintenance Regulation Of Synapse Assembly Regulation Of Neurotransmitter Uptake Regulation Of Dopamine Metabolic Process Cellular Response To Copper Ion Regulation Of Long-term Neuronal Synaptic Plasticity Amyloid Fibril Formation Microglial Cell Activation Presynapse Response To Copper Ion Postsynapse Leukocyte Activation Involved In Inflammatory Response Regulation Of Cell Junction Assembly Beta-tubulin Binding Regulation Of Synapse Organization Regulation Of Neuronal Synaptic Plasticity Protein Destabilization Amyloid-beta Complex Growth Cone Lamellipodium Myeloid Cell Development Regulation Of Response To Calcium Ion Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Terminal Button Organization Regulation Of Amine Transport Positive Regulation Of Protein Localization To Cell Periphery Adult Locomotory Behavior Regulation Of Inflammatory Response Response To Interleukin-1 Negative Regulation Of Transport Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Protein Tetramerization Vesicle-mediated Transport In Synapse Acetylcholine Receptor Activator Activity Modulation Of Chemical Synaptic Transmission	Retromer, Cargo-selective Complex Retromer Complex
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