N4BP2 and TOLLIP

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		N4BP2	TOLLIP
Description		NEDD4 binding protein 2	toll interacting protein
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Region Cytoplasm Endosome Early Endosome Cytosol Nuclear Body Extrinsic Component Of Plasma Membrane Protein-containing Complex Azurophil Granule Lumen Specific Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Nucleotide Binding Endonuclease Activity DNA Endonuclease Activity Protein Binding ATP Binding Hydrolase Activity Ubiquitin Binding ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity	Interleukin-1, Type I Receptor Binding Protein Binding Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding SUMO Binding Toll-like Receptor Binding Ubiquitin Binding Molecular Adaptor Activity
	Biological Process	DNA Metabolic Process	Immune System Process Ubiquitin-dependent Protein Catabolic Process Autophagy Inflammatory Response Signal Transduction Phosphorylation Epithelial Cell Differentiation Positive Regulation Of Protein Sumoylation Protein Localization To Endosome Innate Immune Response Leukocyte Activation Interleukin-1-mediated Signaling Pathway
Pathways			Neutrophil degranulation Interleukin-1 signaling
Drugs
Diseases
GWAS		Platelet thrombus formation ( 22550155)	Gout ( 32238385) Idiopathic pulmonary fibrosis ( 24429156)
Interacting Genes		5 interacting genes: BCL3 CREBBP EP300 NEDD4 TOLLIP	78 interacting genes: ACTMAP ACTN2 ARRDC3 ATXN1 BHLHE40 CDIP1 CHD6 CIMIP2B CPSF6 CSN1S1 CSN2 DAB1 DAZAP2 DCDC2 DDIT4L DZIP3 FAM168A FTH1 GGA1 GGA2 GGA3 GUCD1 HERPUD1 IL1R1 IL1RAP IRAK1 IRAK2 KRTAP13-3 KRTAP15-1 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP7-1 LDB1 MEDAG MSS51 MSX2 MVP N4BP2 NEDD8 NRF1 NTAQ1 ODAM PEG10 PHAF1 PRPF39 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB1 RBFOX1 RBFOX2 RBPMS RHOXF2 RNF167 RNF26 RSPH1 RUNX1 SEPTIN1 SETDB1 SIAH1 STN1 TBX3 TENT5A TLR2 TLR4 TOM1 TOM1L1 TTC9C USP54 WBP2 WRNIP1 XRN2 ZBTB16 ZHX1 ZMYND19
Entrez ID		55728	54472
HPRD ID		11382	05887
Ensembl ID		ENSG00000078177	ENSG00000078902
Uniprot IDs		B2ZZ87 Q86UW6	B3KR28 E9PNS3 F2Z2Y8 Q6FIE9 Q8N8J5 Q9H0E2
PDB IDs		2D9I 2VKC 3BHB 3FAU	1WGL 2N31
Enriched GO Terms of Interacting Partners?		Response To UV Histone H3K27 Acetyltransferase Activity Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Canonical NF-kappaB Signal Transduction Response To Light Stimulus Cellular Response To UV Response To Radiation Cellular Response To Light Stimulus Transcription Coregulator Activity N-terminal Protein Amino Acid Acetylation Leukocyte Activation Peptidyl-lysine Acetylation Regulation Of Cellular Response To Heat Protein Localization To Organelle Cell Activation Cellular Response To Radiation DNA-binding Transcription Factor Binding Acetyltransferase Activity Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Immune System Process Protein-containing Complex Histone Acetyltransferase Complex DNA Damage Response Protein-lysine-acetyltransferase Activity Histone Acetyltransferase Activity Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Acetylation Transcription Coactivator Activity Tau Protein Binding Regulation Of Cellular Response To Growth Factor Stimulus Transcription Coactivator Binding Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Protein Destabilization Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Damaged DNA Binding P53 Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Defense Response Lymphocyte Activation Positive Regulation Of Macromolecule Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Stress Negative Regulation Of RNA Metabolic Process	NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Interleukin-1-mediated Signaling Pathway Endosome Membrane Ubiquitin Binding Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Golgi To Plasma Membrane Protein Transport Lipopolysaccharide-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Matrix Metallopeptidase Secretion Protein Binding Toll-like Receptor Signaling Pathway Intermediate Filament Cell Surface Pattern Recognition Receptor Signaling Pathway Establishment Of Protein Localization To Plasma Membrane Phosphatidylinositol Binding Golgi To Plasma Membrane Transport Interleukin-1 Receptor Activity Toll-like Receptor 2 Signaling Pathway Embryonic Hindlimb Morphogenesis Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Protein Localization To Cell Surface LIM Domain Binding Toll Signaling Pathway Lipopolysaccharide Immune Receptor Activity Interleukin-33-mediated Signaling Pathway Hindlimb Morphogenesis Forelimb Morphogenesis Identical Protein Binding
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