TSR1 and CIDEB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TSR1	CIDEB
Description		TSR1 ribosome maturation factor	cell death inducing DFFA like effector b
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Cytosol Membrane COPII Vesicle Coat COPI-coated Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding GTPase Activity Protein Binding GTP Binding U3 SnoRNA Binding	Protein Binding Identical Protein Binding Molecular Adaptor Activity Phosphatidic Acid Binding Lipid Transfer Activity
	Biological Process	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Ribosome Biogenesis	Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Lipid Storage Response To Nutrient Levels Very-low-density Lipoprotein Particle Assembly Positive Regulation Of Apoptotic Process COPII-coated Vesicle Cargo Loading Regulation Of Triglyceride Metabolic Process Execution Phase Of Apoptosis Intermembrane Lipid Transfer Lipid Droplet Fusion
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Aortic root size ( 19584346) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Schizophrenia ( 25056061 29483656)	Anorectal malformation ( 31136621) Height ( 28552196) Parent of origin effect on language impairment (paternal) ( 24571439)
Interacting Genes		4 interacting genes: BMPR2 CIDEB RHBDD2 SUMO2	68 interacting genes: ABHD16A AFG1L APOC1 ARL8B ATP5ME ATP5MJ BCL2L2 CAND2 CIDEA CLCN1 CMPK1 COL10A1 COL8A1 COX7C DFFA DFFB DHRSX DNAJA3 FAM218A FAM47E-STBD1 FKBP8 FOXD4L3 FUNDC2 GCSH GNB3 GPAM H4C7 HAPLN2 HCCS HIGD1C IRX2-DT MEST MICOS10 MPC2 MRPL36 MRPL57 MTERF4 NAALAD2 NDRG4 NFU1 NME4 PBX3 PDHX PGLYRP3 PISD PPIF RAMP2 RHBDD2 ROMO1 RTP5 SAA2 SAA4 SAR1B SCO1 SCO2 SDHAF1 SFXN1 SMARCC1 SPG21 TAOK2 TBX2 TEX44 THBD TIMM17B TMEM14B TPRG1 TSR1 UFSP1
Entrez ID		55720	27141
HPRD ID		07681	11981
Ensembl ID		ENSG00000167721	ENSG00000136305
Uniprot IDs		Q2NL82	Q9UHD4
PDB IDs		6G18 6G4S 6G4W 6G51 6G53 6ZMT 6ZN5 7WTS 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 8ZDC 8ZDD	1D4B
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Chondrocyte Proliferation Regulation Of Lung Blood Pressure Aortic Valve Development Lymphatic Endothelial Cell Differentiation BMP Receptor Activity Pulmonary Valve Development Tricuspid Valve Morphogenesis Venous Blood Vessel Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Activin Receptor Activity, Type II Endochondral Bone Morphogenesis Transforming Growth Factor Beta Receptor Activity Semi-lunar Valve Development Mitral Valve Morphogenesis Lipid Droplet Fusion Signal Recognition Particle Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Axon Extension Involved In Axon Guidance Maternal Placenta Development Lung Vasculature Development Lymphangiogenesis Negative Regulation Of Vasoconstriction Cellular Response To Stress Endocardial Cushion Development Pharyngeal Arch Artery Morphogenesis Retina Vasculature Development In Camera-type Eye Endothelial Cell Apoptotic Process Atrial Septum Morphogenesis Protein Tag Activity COPI-coated Vesicle COPII Vesicle Coat Lipid Transfer Activity Very-low-density Lipoprotein Particle Assembly Regulation Of Cell Proliferation Involved In Heart Morphogenesis COPII-coated Vesicle Cargo Loading Atrioventricular Valve Morphogenesis Response To Nutrient Levels SUMO Transferase Activity BMP Binding Heart Valve Development Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Execution Phase Of Apoptosis Phosphatidic Acid Binding Protein-lipid Complex Assembly Plasma Lipoprotein Particle Assembly Ubiquitin-like Protein Ligase Binding Outflow Tract Septum Morphogenesis	Mitochondrion Mitochondrial Inner Membrane Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of Apoptotic DNA Fragmentation High-density Lipoprotein Particle Protein Binding Mitochondrion Organization Mitochondrial Membrane Copper Chaperone Activity Disordered Domain Specific Binding T Cell Apoptotic Process Mitochondrial Matrix Organophosphate Biosynthetic Process Cytochrome Complex Assembly Pyruvate Decarboxylation To Acetyl-CoA Activation-induced Cell Death Of T Cells Mitochondrial Respiratory Chain Complex Assembly Lymphocyte Apoptotic Process Import Into The Mitochondrion Negative Regulation Of Execution Phase Of Apoptosis Protein Localization To Mitochondrion
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